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more on tramadol - Peter

Posted by Elizabeth on May 20, 1999, at 21:39:39

In reply to Re: buprenorphine experience, posted by Peter on May 20, 1999, at 19:41:57

Yeah, here are a few refs on tramadol:

Markowitz JS, et al.
Venlafaxine-tramadol similarities.
Med Hypotheses. 1998 Aug;51(2):167-8.

Rojas-Corrales MO, et al.
Tramadol induces antidepressant-type effects in mice.
Life Sci. 1998;63(12):PL175-80.


Bono AV, et al.
[Effectiveness and tolerance of tramadol in cancer pain. A comparative study with respect to buprenorphine].
Drugs. 1997;53 Suppl 2:40-9. French.

Goldsmith TB, et al.
Rapid remission of OCD with tramadol hydrochloride.
Am J Psychiatry. 1999 Apr;156(4):660-1.

Shapira NA, et al.
Open-label pilot study of tramadol hydrochloride in treatment-refractory obsessive-compulsive disorder.
Depress Anxiety. 1997;6(4):170-3.

I should also mention that because of its monoamine reuptake inhibition activity, tramadol must not be used with an MAO inhibitor and probably should not be used with SSRIs either (there have been some reports of serotonin syndrome with this combination).

It's an option, although I think that Nardil would probably be a better choice since Parnate worked initially. Sometimes you need to use aggressive dosing and augmentation with those.

Also, if you had hypomania on antidepressants, that suggests that maybe a mood stabilizer like Lamictal or full-dose lithium would benefit you. They sometimes take a while to produce results for dysthymia, but the results are robust.

Can I ask if you have any symptoms other than depressed mood?




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