Psycho-Babble Medication | about biological treatments | Framed
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Re: naltrexone

Posted by paul on April 19, 1999, at 10:22:43

In reply to naltrexone, posted by paul on April 19, 1999, at 10:01:37

> Please put me on your "mailing list" for info on opioid agonists/antagonists in the treatment of depression, dysthymia, etc. It seems that if opioid agonists, whose primary mechanism of action is typically associated with (short-term) euphoria (often listed as a "side effect" in medical texts), then it should follow that antagonists would have no mood-elevating effects whatsoever.
> I am fascinated with the seemingly paradoxical effects of antagonists, I would be interested in joining this discussion. I'm also interested in the effects of mixed agonists/antagonists.
> Thanks.

I posted the above message before I read the hypotheses/theories that preceded it. Very interesting. Is the idea of naltrexone as an adjunct to SSRI's new in the psychiatric community? In other words, is the average psychiatrist familiar with such treatment? Also, is this augmentation particularly useful in those with a propensity to abuse (oral only) opioids, such as hydrocodone? I take Zoloft and while I don't have a serious problem, I do have an affinity for things that attach to my opioid receptors.




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