Psycho-Babble Medication Thread 1122108

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Novel Antidepressants in the Pipeline

Posted by SLS on June 26, 2023, at 9:44:26

Novel Antidepressants in the Pipeline (Phase II and III): A Systematic Review of the US Clinical Trials Registry


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259184/

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Re: Novel Antidepressants in the Pipeline

Posted by Hugh on June 29, 2023, at 19:23:42

In reply to Novel Antidepressants in the Pipeline, posted by SLS on June 26, 2023, at 9:44:26

One novel treatment for depression I will add to this is H2 (hydrogen) therapy -- both hydrogen inhalation and by drinking hydrogen-rich water.

https://nulifesciences.com/the-science/effects-of-hydrogen-water-on-depression/

https://www.mdpi.com/2076-3921/11/11/2153

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731988/

I ordered a machine from Amazon that produces both hydrogen for inhalation and hydrogen-rich water. It produces hydrogen from a small amount of distilled water that only has to be replaced after about 20 hours of use. The machine costs $559. It's a portable model that produces 150 ml of hydrogen per minute. Machines that produce 300 ml per minute cost about twice as much. It's arriving tomorrow. At some point in the future, I will post about my experiences with hydrogen.

Tablets that produce hydrogen-rich water are available online. I haven't tried these.

 

Re: Novel Antidepressants in the Pipeline

Posted by SLS on June 29, 2023, at 20:53:10

In reply to Re: Novel Antidepressants in the Pipeline, posted by Hugh on June 29, 2023, at 19:23:42

Hi, Hugh.


> One novel treatment for depression I will add to this is H2 (hydrogen) therapy -- both hydrogen inhalation and by drinking hydrogen-rich water.
>
> https://nulifesciences.com/the-science/effects-of-hydrogen-water-on-depression/
>
> https://www.mdpi.com/2076-3921/11/11/2153
>
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731988/
>
> I ordered a machine from Amazon that produces both hydrogen for inhalation and hydrogen-rich water. It produces hydrogen from a small amount of distilled water that only has to be replaced after about 20 hours of use. The machine costs $559. It's a portable model that produces 150 ml of hydrogen per minute. Machines that produce 300 ml per minute cost about twice as much. It's arriving tomorrow. At some point in the future, I will post about my experiences with hydrogen.
>
> Tablets that produce hydrogen-rich water are available online. I haven't tried these.


I can't believe the stuff you come up with. It was the information you provided regarding psilocybin that persuaded me to make it my first choice should I relapse. I would leave all of my meds in place and take a series of doses of psilocybin. I would hope that this would promote enough neuroplasticity to allow the brain to break free of some sort of sticking point.

This is all an abstraction, of course.

Do you think microdoses of psilocybin are as effective as psychedelic dosages? How often would you take microdoses? Once a day? Once a week?

I don't think there is an untoward interaction between a MAOI and psilocybin. I'll have to remember where I read that.

I appreciate your dropping in.

It gets lonely when you chase all of your friends away with a manic / hypomanic episode. A few months ago, I suffered a horrendous episode of pain due to lumbar spinal stenosis. I couldn't walk without screaming. So, I screamed. I was prescribed prendisone. Then, I was put on meloxicam (Mobic), a NSAID. Fortunately, my pharmacist told me that meloxicam interacts with lithium to increase blood levels of lithium. I started to become toxic. It was a real mess.

One week of mania can destroy a life more completely than months or years of depression. Believe it.

It was my intention to post without any social interaction just to provide information for anyone who might visit the board.

I will take a look at your citations. Thank you, Hugh.


- Scott

 

Re: Novel Antidepressants in the Pipeline ╗ SLS

Posted by Hugh on June 30, 2023, at 10:24:55

In reply to Re: Novel Antidepressants in the Pipeline, posted by SLS on June 29, 2023, at 20:53:10

Hi Scott,

> Do you think microdoses of psilocybin are as effective as psychedelic dosages? How often would you take microdoses? Once a day? Once a week?
>

James Fadiman, probably the leading authority on psychedelic microdosing, says that he doesn't know if microdoses improve neuroplasticity, since virtually all of the research that's been done on psychedelics has been on doses far larger than microdoses. But Fadiman thinks it's very likely that microdosing improves neuroplasticity, because when people who've been microdosing for a while stop, many report that they continue to feel well.

Most people microdose psychedelics once every three days. Some people do it every other day; some do it two days on, two days off. However it's done, it's important to regularly take a day or two off to prevent tolerance from developing. Fadiman says that he tells people to microdose once every three days for the first month, and then to figure out their own schedule -- to do whatever seems right to them. He says that after the first month of microdosing, most people start doing it less than once every three days.

> It gets lonely when you chase all of your friends away with a manic / hypomanic episode. A few months ago, I suffered a horrendous episode of pain due to lumbar spinal stenosis. I couldn't walk without screaming. So, I screamed. I was prescribed prendisone. Then, I was put on meloxicam (Mobic), a NSAID. Fortunately, my pharmacist told me that meloxicam interacts with lithium to increase blood levels of lithium. I started to become toxic. It was a real mess.
>
> One week of mania can destroy a life more completely than months or years of depression. Believe it.
>

I'm sorry to hear that. Try not to be so hard on yourself. For many years, you've done more than anyone to keep Psycho-Babble going. You've reached out to countless people to try to help them with your expertise. It's hard to imagine Psycho-Babble without you.

 

Re: Novel Antidepressants in the Pipeline ╗ Hugh

Posted by SLS on June 30, 2023, at 20:48:36

In reply to Re: Novel Antidepressants in the Pipeline ╗ SLS, posted by Hugh on June 30, 2023, at 10:24:55

Oh. I looked into the hydrogen thing. It turns out that one of the side effects is spontaneous human combustion.


- Scott

 

Re: Novel Antidepressants in the Pipeline ╗ SLS

Posted by Hugh on June 30, 2023, at 21:27:37

In reply to Re: Novel Antidepressants in the Pipeline ╗ Hugh, posted by SLS on June 30, 2023, at 20:48:36

Do you have a link for that, or are you joking?

> Oh. I looked into the hydrogen thing. It turns out that one of the side effects is spontaneous human combustion.
>
>
> - Scott

 

Re: Novel Antidepressants in the Pipeline ╗ Hugh

Posted by SLS on July 1, 2023, at 0:40:04

In reply to Re: Novel Antidepressants in the Pipeline ╗ SLS, posted by Hugh on June 30, 2023, at 21:27:37

> Do you have a link for that, or are you joking?
>
> > Oh. I looked into the hydrogen thing. It turns out that one of the side effects is spontaneous human combustion.
> >
> >
> > - Scott

I guess my delivery was too dry.

Cold fusion, maybe?

I admit that most of my jokes are designed for an audience of one.

My fiancee usually laughs at all of my jokes. Not so much yesterday, though. She always needs a cup of coffee first thing in the morning. She isn't quite right until she does. Well, I guess I told her my joke too early in the morning. I found it amusing and worthy of at least a chuckle. No laughter? So, I asked her if she had had her coffee yet. Quite seriously, she asked, "What makes you think your joke will be any funnier after I do?" I laughed uncontrollably for about 10 minutes.

In all seriousness, I think humor played an important role in my waking up each morning during 40 years of failed treatments and pain.

Your words to me were very kind and greatly appreciated.


- Scott

 

Re: Novel Antidepressants in the Pipeline ╗ SLS

Posted by Hugh on July 2, 2023, at 14:27:08

In reply to Re: Novel Antidepressants in the Pipeline ╗ Hugh, posted by SLS on July 1, 2023, at 0:40:04

When I read your post, I'd just finished doing a two-hour hydrogen inhalation session, plus I drank two glasses of hydrogen-rich water, so I was feeling a little woozy and was slower than usual on the uptake. When I became fully alert, I realized that you were joking.

When I was in junior high, I became fascinated with spontaneous human combustion, and read everything I could find on it. Years later, I came across the following article about it in New Scientist:

Big burn theory: Why humans spontaneously combust

Updated 18:30 28 August 2012 by Brian J. Ford
Magazine issue 2878.

Spontaneous human combustion is a macabre phenomenon people either dismiss as a myth or blame on alcoholism. Brian J. Ford thinks he's found the real answer

PEOPLE explode. One minute they may be relaxing in a chair, the next they erupt into a fireball. Jets of blue fire shoot from their bodies like flames from a blowtorch, and within half an hour they are reduced to a pile of ash. Typically, the legs remain unscathed, sticking out grotesquely from the smoking cinders. Nearby objects (a pile of newspapers on the armrest, for example) are untouched. Greasy fat lies on the floor. For centuries, this gruesome way of death has been debated, with many people discounting it as a myth. But spontaneous human combustion is real and we think we can show how it happens.

The first accounts date from 1641, when Danish doctor and mathematician Thomas Bartholin described the death of Polonus Vorstius -- who drank wine at home in Milan, Italy, one evening in 1470 before bursting into flames. In 1663, Bartholin wrote of a Parisian woman who burned, leaving the mattress on which she lay unscathed. And in the Philosophical Transactions of 1745, Paul Rolli told how 62-year-old Countess Cornelia Bandi of CesÚna, Italy, said she felt "dull and heavy" after dining and went to bed. Next morning, her maid found a pile of ash with her legs protruding from the smouldering remains.

The first monograph on the subject was Essai sur les Combustions Humaines, produits par un long abus des liqueurs spiritueuses by French writer Pierre Aime Lair in 1800. This set a moralistic tone that others followed, and alcoholism became accepted as the cause of combustion. In 1853, the Victorian magazine Notes and Queries included a summary of 19 cases between 1692 and 1829 by a Dr Lindsley, who wrote that those who had died of the condition were "habitually drunken" or "frequently indulged" in alcohol.

The first scientist to investigate spontaneous human combustion was German chemist Justus von Liebig, who examined the records of some 50 cases. He pointed out that even though anatomical specimens are stored in 70 per cent alcohol, they will not burn. He injected rats with ethanol and still could never make them catch light. This essentially disproved the causal link between alcoholism and combustion, but the belief persisted.

Recent cases are well documented. On 1 July 1951, Mary Reeser was visited at her home in St Petersburg, Florida, by her son, but when a telegram arrived next day, the doorknob of Reeser's apartment was found to be hot. When police broke in, all they found was a mound of smoking ash with a leg protruding and charred liver attached to the spine.

The remains of John Irving Bentley of Coudersport, Pennsylvania, were found by a meter reader who let himself in on 5 December 1966. A pile of ash and half a leg was what remained. And the most recent case was 76-year-old Michael Faherty who died on 22 December 2010. West Galway coroner Ciaran McLoughlin recorded the cause of death as spontaneous human combustion.

In 1961, London coroner Gavin Thurston published a paper, "Preternatural combustibility of the human body", in the Medico-Legal Journal. He described a potential mechanism for such combustion: the "wick effect". Human fat burns at about 250 Celsius, but if melted it will combust on a wick at room temperatures. He experimented with a roll of fat wrapped in gauze, and showed that the heat of the flame could melt body fat and produce continuous combustion like a candle.

In January 1986, a BBC Newsnight programme demonstrated the wick effect. The following year, Nigel Cruttenden of the Kent Police Force used the wick effect to explain the death on 28 December 1987 of Barry Soudain, a handyman from Folkestone, UK. Soudain's charred remains were found in his largely undamaged flat. Cruttenden surmised that fat in the body had liquefied in the conflagration and fuelled the fire. The wick effect was becoming the accepted explanation. Yet clothing soon burns away, leaving no wick; combustion lasts 12 hours or more, and the corpse is not destroyed. Spontaneous human combustion is a very different matter.

A decade on, in August 1998, the BBC set out to show in an episode of its QED series entitled "The Burning Question" that spontaneous human combustion was explained by conventional means. Among the experts was Dougal Drysdale, from the University of Edinburgh, who heated a piece of pig bone to 500 Celsius in a muffle furnace. After 6 hours, he assured his audience, the bone would be reduced to ash. Drysdale inspected the bone after 8 hours, but it was still intact.

Stan Ames of the Fire Research Station, a British research unit, also appeared -- to demonstrate how easy it was for a wooden-framed armchair to be destroyed by fire. The commentary said that the burning could reduce a body to ash, or, in this case, an armchair to its springs. The chair was left to burn for 6 hours in an experimental chamber, at the end of which it was largely intact. Part of the back and the armrest were charred. Setting fire to a combustible armchair is hardly comparable to burning a moist human body, and we failed to see the relevance; still the BBC proclaimed that its programme meant that the "mystery" of spontaneous combustion was "finally solved".

I felt it was time to test the realities, so we marinated pork abdominal tissue in ethanol for a week. Even when cloaked in gauze moistened with alcohol, it would not burn. Alcohol is not normally present in our tissues, but there is one flammable constituent of the body that can greatly increase in concentration. Triacylglycerol lipids cleave to form fatty acid chains and glycerol. The fatty acids can be used as an alternative source of energy through beta-oxidation, giving rise to the key metabolic molecule acetyl-CoA. This helps drive the energy-producing Krebs cycle within the mitochondria of cells.

If the body's cells are starved (which can occur during chronic illness and even during a workout at the gym), acetyl-CoA in the liver is converted into acetoacetate, which can decarboxylate into acetone. And acetone is highly flammable. A range of conditions can produce ketosis, in which acetone is formed, including alcoholism, high-fat low-carbohydrate dieting, diabetes and even teething. So we marinated pork tissue in acetone, rather than ethanol.

This was used to make scale models of humans, which we clothed and set alight. They burned to ash within half an hour. The remains -- a pile of smoking cinders with protruding limbs -- were exactly like the photographs of human victims. The legs remain, we think, because there is too little fat for much acetone to accumulate. For the first time a feasible cause of human combustion has been experimentally demonstrated.

So does this mean that victims of ketosis are likely to spontaneously combust? Hardly -- there are only about 120 cases on record throughout history, so it is vanishingly rare. On the other hand, there would be an argument against people with ketosis wearing synthetic fibres on dry days, and a new argument to give up smoking.

Meanwhile, I sympathise with teenagers whose parents have repeatedly been told that the odour of solvent on a child's breath is a sure sign of glue-sniffing. It isn't of course: they were probably dieting or just unwell.

An earlier version of this article mistakenly said that fat-free dieting can cause ketosis. It can't, but high-fat, low-carbohydrate dieting may do so
Profile

Brian J. Ford is a research biologist and author of more than 30 books, most about cell biology and microscopy. He lectures worldwide, and broadcasts on radio and television. This article is based on his recent paper in The Microscope (vol 60, p 63).


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