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Re: Lyrica tolerance

Posted by Cairo on February 24, 2006, at 15:32:38

Going to start Lyrica tonight for chronic pain. I developed tolerance with Neurontin and couldn't go too high on the dose due to side effects (not to mention decreased absorption with increasing dose). Had to increase, decrease, then stop and start all over again to reestablish effect. I was told today by a FMS research assistant that she's seen that happen in a couple of Lyrica patients in their FMS study. Should I expect tolerance to develop with Lyrica as it did with Neurontin or not? I know Lyrica has linear absorption.

Also, I'd like to get off clonazepam (0.5mg HS) for panic attacks that were induced (uncovered?) by a trial of Topamax. Any thoughts as to whether Lyrica will help with the panic attack symptoms (mostly physical now; going to ask to go back to propranol or pindolol from atenolol which my Internist switched me to because of "less side effects". Atenolol not as effective, though, for the sweats and nerves that are completely random.

Reasonable guesses appreciated.





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