Psycho-Babble Alternative Thread 981870

Shown: posts 1 to 25 of 28. This is the beginning of the thread.

 

fibromyalgia is here....

Posted by floatingbridge on April 3, 2011, at 17:38:55

So. A new game is afoot. So is a new learning curve.

Read that glutamate is a neuroexcitor. (Spelling! Please forgive.)

That a med (effirma) works on nmda receptors as a novel approach to pain control.

What can I take otc to elicit similar
response (maybe, perhaps?)?

MD said to take L-Glutamine. (Before the officually accepted dx. She's away. I feel
like cr*p, Mack truck variety.)

Am I shooting myself in the foot (with a pea-shooter)?

Thanks,

fb

 

oh gawd, yes. floatingbridge

Posted by floatingbridge on April 3, 2011, at 17:49:58

In reply to fibromyalgia is here...., posted by floatingbridge on April 3, 2011, at 17:38:55

L-glutamine goes bye-bye.

One quick Google.

Onward to inviting nmda aboard.

Any thoughts?

 

Re: fibromyalgia is here....

Posted by sigismund on April 3, 2011, at 20:01:17

In reply to fibromyalgia is here...., posted by floatingbridge on April 3, 2011, at 17:38:55

Your MD said that (about glutamine)?

I've forgotten now.

magnesium glycinate?

 

Re: fibromyalgia is here.... sigismund

Posted by floatingbridge on April 4, 2011, at 0:05:00

In reply to Re: fibromyalgia is here...., posted by sigismund on April 3, 2011, at 20:01:17

Umm. No. I've got it mixed up.

I read about effirma. An nmda antagonist (for awhile I thought it was an nmda agonist, but another quick Google disabused me of that mistake).

My gp is away until the 14th and this dx came in while she is away.

I'm not sure what you're asking she said.

She told me to take L-glutathione. For muscle health (she was thinking I might have something like complex regional pain syndrome).

Effirma is/was being piloted as novel pain relief and treatment for fibromyalgia. One action is a decrease in
glutamate levels. Research suggests fibro-types have high glutamate levels.

So.... I'm moving glacially slow, adding supplements one by one. Gaba, taurine,
l-glutamine, subtracting l-glutamine, dl-phenyalanine, krill oil.

Tonight I'm adding a sleep treatment tried on some fibromyalgia patients:

5mg melatonin
225mg magnesium
12mg zinc

Do you know anything about nmda antagonists?

Wish me luck.

AD-free,

fb

 

Re: fibromyalgia is here.... floatingbridge

Posted by sigismund on April 4, 2011, at 3:41:37

In reply to Re: fibromyalgia is here.... sigismund, posted by floatingbridge on April 4, 2011, at 0:05:00

I think glutamine will not help with NMDA toxicity but rather predispose you to it.

Is Namenda (memantine) useful for NMDA toxicity?
(long half life, dubious drug)

There are lots of threads about memantine on Babble which you could search for.

Is glutathione is well absorbed from the gut?

 

glutathione

Posted by floatingbridge on April 4, 2011, at 10:05:10

In reply to Re: fibromyalgia is here.... floatingbridge, posted by sigismund on April 4, 2011, at 3:41:37

> I think glutamine will not help with NMDA toxicity but rather predispose you to it.
>
> Is Namenda (memantine) useful for NMDA toxicity?
> (long half life, dubious drug)
>
> There are lots of threads about memantine on Babble which you could search for.

Thanks for the search tips ^. What is questionable re: nameda?


>
> Is glutathione is well absorbed from the gut?


I don't know this one. It's a variant of l-glutamine? Are all the supplements that
begin with 'gluta' related? Oh dear.

Jeez, back to a basic reference for me. Know of one?

(Think my MD suggested the l-glutamine to help with muscle growth or muscle tissue 'retention'. I'm shelving it until she returns and I understand it's function more clearly.)

Thanks, Sigi.

 

Re: glutathione floatingbridge

Posted by Phillipa on April 4, 2011, at 11:22:59

In reply to glutathione, posted by floatingbridge on April 4, 2011, at 10:05:10

FB to build muscle excercise is necessary is it an animo acid that is used by body builders? There is a test now other than pressure points for fibromyalgia? What kind is it as didn't know that? Love Phillipa

 

Re: glutathione

Posted by sigismund on April 4, 2011, at 14:47:57

In reply to glutathione, posted by floatingbridge on April 4, 2011, at 10:05:10

Glutamine is properly given to help with gut permeability in leaky gut syndrome, but otherwise might be best avoided.

Memantine is a drug many have tried without brilliant results, as I recall, but not terrible results either. Interestingly, it is said to help with amphetamine and opiate dependence and even opiate withdrawal. I don't understand how this might be the case.

 

Re: glutathione sigismund

Posted by floatingbridge on April 4, 2011, at 17:05:04

In reply to Re: glutathione, posted by sigismund on April 4, 2011, at 14:47:57

Thanks Sigi, metamine is ringing a bell, ...somewhere. Considering I stopped dex a short while back and want to dump norco, hmmmm.

More Googling.

:)

 

Re: glutathione Phillipa

Posted by floatingbridge on April 4, 2011, at 17:12:04

In reply to Re: glutathione floatingbridge, posted by Phillipa on April 4, 2011, at 11:22:59

Hi Phillipa,

No new test, just read that the fibromyalgia population (notorious for complaints without any markers) can test high for glutamates. An educated guess might be to decrease neuroexcitors in folks with overactive signals.

Was also reading that in fibromyalgia, there seems to be a build up of...? Is it uric acid, phosphates, both? Basically what another person may pass off (shrug off) in urine instead remains in muscles.

This is just what I've been able to grab quickly and is still not thought through.

Thanks for your support :)

fb

 

Re: glutathione floatingbridge

Posted by sigismund on April 4, 2011, at 17:32:37

In reply to Re: glutathione sigismund, posted by floatingbridge on April 4, 2011, at 17:05:04

I think your best bet with hydrocodone is to taper it.

You cannot stop it without some withdrawal.

There are different theories. There is the one about kindling, and then there is the idea that you have so much pain to go through and it is a question of how you want to take it.

I think it is best to take it in doses so you can still function relatively normally. For some people this means almost endless slow withdrawal. It is not to everyone's taste, but there is something to be said for it. Go on 10 a day and stay there for a month. You don't like the sound of that?

 

Re: glutathione sigismund

Posted by floatingbridge on April 4, 2011, at 17:39:12

In reply to Re: glutathione floatingbridge, posted by sigismund on April 4, 2011, at 17:32:37

Sigi, thing is, I think it is responsible for these awful headaches. I never had them much before. And the norco does nothing to stop. So I do suspect of creating new pain (arrggh).

I have another thread on med about using a bit of ultram if I knew the withdrawal window for norco and the beginning of dependence window for the ultram (tramadol er).

Thanks for posting:)

 

Re: glutathione

Posted by sigismund on April 4, 2011, at 17:57:03

In reply to Re: glutathione sigismund, posted by floatingbridge on April 4, 2011, at 17:39:12

>I think it is responsible for these awful headaches

What is?

withdrawal from paracetamol?
withdrawal from hydrocodone?
Something else?

 

Re: glutathione

Posted by floatingbridge on April 4, 2011, at 20:55:46

In reply to Re: glutathione, posted by sigismund on April 4, 2011, at 17:57:03

> >I think it is responsible for these awful headaches
>
> What is?
>
> withdrawal from paracetamol?
> withdrawal from hydrocodone?
> Something else?

I suspect the hydrocodone. Is
paracetamol also called tylenol? (The other agent in norco.)

I can't believe I cannot get my doctor's help in any timely fashion. This is frustrating; I have been patient, and I'm about to go renegade and self-treat.

I either make a big stink at the office, drape myself on the carpet, and claim an emergency, or quietly endure, and endure headaches. I have been telling the front office all my symptoms....

 

Luteolin!

Posted by morgan miller on April 5, 2011, at 0:30:07

In reply to Re: glutathione, posted by floatingbridge on April 4, 2011, at 20:55:46

FB, sorry you are still struggling with medications, side effects, and fibromyalgia. You mentioned you have an autoimmune disorder before. Have you heard of Luteolin? This might be worth doing some research on. LuteMax is one of the only luteolin supplements I know of. It is expensive, but it sounds like it really might be worth taking for many people.

http://www.immunobiotics.com/pdf/ms/Luteolin%20MS%20Verbeck.pdf

http://www.brjpharmacol.org/details/journalArticle/142995/Luteolin_inhibits_myelin_basic_proteininduced_human_mast_cell_activation_and_mas.html

http://www.ncbi.nlm.nih.gov/pubmed/19076366

http://www.ncbi.nlm.nih.gov/pubmed/15276069

Morgan

 

Re: Luteolin!

Posted by morgan miller on April 5, 2011, at 0:31:18

In reply to Luteolin!, posted by morgan miller on April 5, 2011, at 0:30:07

OOps, it's LutiMax : )

 

Re: glutathione floatingbridge

Posted by morgan miller on April 5, 2011, at 0:34:19

In reply to Re: glutathione, posted by floatingbridge on April 4, 2011, at 20:55:46

Low glutathione production may be reason for fibromyalgia symptoms. Milk thistle, NAC, undenatured whey protein, and schisandra are all known for their ability to assist in the bodies production of glutathione. There are several more, but I can't think of them at the moment.

Feel better FB,

Morgan

 

Re: glutathione floatingbridge

Posted by SLS on April 5, 2011, at 5:09:44

In reply to Re: glutathione sigismund, posted by floatingbridge on April 4, 2011, at 17:39:12

Just a guess...

Clonidine + anticonvulsant (Trileptal or Topamax)


- Scott

 

Re: glutathione morgan miller

Posted by SLS on April 5, 2011, at 5:19:15

In reply to Re: glutathione floatingbridge, posted by morgan miller on April 5, 2011, at 0:34:19

> Low glutathione production may be reason for fibromyalgia symptoms. Milk thistle, NAC, undenatured whey protein, and schisandra are all known for their ability to assist in the bodies production of glutathione. There are several more, but I can't think of them at the moment.
>
> Feel better FB,
>
> Morgan

Hi Morgan.

I might try NAC to help prevent neural mitochondrial damage by free radicals.

I'm also looking at phosphatidylserine for neural membrane growth and stabilization.


- Scott

 

Re: glutathione SLS

Posted by floatingbridge on April 5, 2011, at 11:41:51

In reply to Re: glutathione floatingbridge, posted by SLS on April 5, 2011, at 5:09:44

Hi Scott,

Is this a guess at getting off norco? (I wasn't sure...).

Thanks

fb

> Just a guess...
>
> Clonidine + anticonvulsant (Trileptal or Topamax)
>
>
> - Scott

 

Re: Luteolin! morgan miller

Posted by floatingbridge on April 5, 2011, at 11:50:23

In reply to Re: Luteolin!, posted by morgan miller on April 5, 2011, at 0:31:18

> OOps, it's Luti-max : )

Morgan, thanks for weighing in. I have hashimoto's, thyroid antibodies. Oddly, my tsh level recently spiked to 5.07 up from 1.9 three months ago. Only recourse clinically is to increase thyroid (armor). Oddly, again, I usually overshoot the tsh target initially, and tsh numbers come in too low. Once .02!

I also am experiencing menopause. Tra, Laa, La. Try to get one or two doctors to see a larger pic; you know, various organs or systems intermeshing. Right now, I think of my situation as a 'perfect storm' :(

I'll check this out.

 

lithium + thyroid SLS

Posted by floatingbridge on April 5, 2011, at 11:57:02

In reply to Re: glutathione morgan miller, posted by SLS on April 5, 2011, at 5:19:15

Scott,

My understanding is that prolonged lithium use can (not will) lead to gradual thyroid failure. I have not heard of thyroxine (sp) used prophylactically.

In my case, pdoc was very cautious adding lithium and wanted my thyroid tested every 6-8 weeks. Thyroid issues and lithium use are considered contraindicated.

fb

 

Re: glutathione

Posted by morgan miller on April 5, 2011, at 22:41:19

In reply to Re: glutathione morgan miller, posted by SLS on April 5, 2011, at 5:19:15


> Hi Morgan.
>
> I might try NAC to help prevent neural mitochondrial damage by free radicals.
>
> I'm also looking at phosphatidylserine for neural membrane growth and stabilization.
>
>
> - Scott

I take NAC at night 4 or 5 days a week. PS for some reason makes me feel funny, at least I think it was the PS. I may try it at some point again in the future.

Keep feeling better Scott!

Morgan

 

Re: Luteolin!

Posted by morgan miller on April 5, 2011, at 22:43:24

In reply to Re: Luteolin! morgan miller, posted by floatingbridge on April 5, 2011, at 11:50:23

> > OOps, it's Luti-max : )
>
> Morgan, thanks for weighing in. I have hashimoto's, thyroid antibodies. Oddly, my tsh level recently spiked to 5.07 up from 1.9 three months ago. Only recourse clinically is to increase thyroid (armor). Oddly, again, I usually overshoot the tsh target initially, and tsh numbers come in too low. Once .02!
>
> I also am experiencing menopause. Tra, Laa, La. Try to get one or two doctors to see a larger pic; you know, various organs or systems intermeshing. Right now, I think of my situation as a 'perfect storm' :(
>
> I'll check this out.
>

I would check out DIM also for menopause. It positively impacts estrogen metabolites toward the good one and away from the bad. I hear women swearing by it all the time at work.

Morgan

 

Re: glutathione floatingbridge

Posted by SLS on April 6, 2011, at 5:29:57

In reply to Re: glutathione SLS, posted by floatingbridge on April 5, 2011, at 11:41:51

> Hi Scott,
>
> Is this a guess at getting off norco?


Yes. You can find abstracts on Medline (Pubmed) that suggest these two drugs are effective in managing opioid withdrawal.


- Scott


Go forward in thread:


Show another thread

URL of post in thread:


Psycho-Babble Alternative | Extras | FAQ


[dr. bob] Dr. Bob is Robert Hsiung, MD, dr-bob@uchicago.edu

Script revised: October 4, 2007
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-08 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.