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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by Jay2112 on February 18, 2023, at 17:06:00
OK: (a story, but I am desperate for help)
I take adderallXR, 15mg a day. To me, it is the KEY, perfect drug for me. I find I am dependent, not addicted. I have been taking it everyday for almost 2 months (other stims over 12 years.) I tried days without it, and I go back to my old, depressed self who can't barely get out of bed. I was dx'ed with ADD (no H) about 12 years ago. It, Dexedrine, and Vyvanse got me through the death of my partner and daughter,parents, and the death of my dog (which all, almost killed me.) It boosted a lowered spirit no regular antidepressant could ever touch!! But, again, I wasn't manic...or high....I was back to "me" who was before I eas dx'ed!!
Question is...I have no problem taking it, or other stims, daily. I am just, calmly, my authentic self...which includes an element of the 'old' self these meds can touch. If I feel 'fine', with no dose increase,
****WOULD TAKING 15MG OF ADDERALL (MIXED AMPHETAMINE SALTS) EVERY DAY FOR THE REST OF MY LIFE BE FINE??*****
As I said, I have been pretty much doing the same with vyvanse, and dexedrine.
I am looking also for other dopamine agonists that feel smooth. (Wellbutrin drove me crazy), and the partial agonists in some antipsychotics cause me WAY too much akathisia.
The only other agonists covered by my drug plan include Pramipexole (Mirapex). ...
Bromocriptine and. ...
Rotigotine (Neupro)So, I don't know what the heck I need to do...lol. I have axed Effexor from my regimen, and my anxiety feels ohhh so much better! I only use two tiny doses of fluoxetine, poured from the capsule, and aa smidge of a 5mg tab of vortioxetine. They actually put me to sleep! And, 15mg of mirtazapine.Oh, plus clonazepam, and 150mgs of lithium. Thankfully, my pdoc's are NOT afraid to use controlled drugs, responsibly. (I study addictions in my college post grad cert, so I know a few things about it..lol)
One little theory I have....and NO, I am not some wacko scientologist. But I was on VERY high doses of some of these meds. 120mg of fluoxetine; 450mg of venlafaxine; almost 40mg of escitalopram; 200mg of amitriptyline; and over 1000mg's (1 gram) of divalproex. Plus the antipsychotics...8mg of risperdall; 25mg of olanzapine. None of these were actually prescribed. I cranked up the doses myself. I remember getting up for work and falling often in the morning; my parents could tell when I was on the full dose of these drugs, my eyes were puffy and dilated...they (rightfully) wouldn't let me drive! But I JUST WANTED to KILL THE DAMN ANXIETY!! Plus, I have Asperger's, and high serotonin levels can really fr*g things up! I think there were some changes in my biology that dampened or danaged my dopamine system.
(But, no, no desire to 'abuse' stims..and I am very logical, coherent on them.)
So, my question is above.
I feel ok-well, but just like I am on uneasy ground.
Thanks, with kindness,
Jay
Posted by NKP on February 19, 2023, at 9:50:17
In reply to adderallXR: NEED help please..everyone, posted by Jay2112 on February 18, 2023, at 17:06:00
> Plus, I have Asperger's, and high serotonin levels can really fr*g things up!
Why is that?
Posted by undopaminergic on February 21, 2023, at 9:59:37
In reply to adderallXR: NEED help please..everyone, posted by Jay2112 on February 18, 2023, at 17:06:00
>
> ****WOULD TAKING 15MG OF ADDERALL (MIXED AMPHETAMINE SALTS) EVERY DAY FOR THE REST OF MY LIFE BE FINE??*****
>Amphetamines can be neurotoxic. It's just not clear how much is too much.
It appears extracellular dopamine can be converted to dopaquinones which cause oxidative stress, which can damage nerve terminals (which is from where the dopamine is released into the synapse). It happens in methamphetamine abuse, and I'm pretty sure it happened to me with phenylethylamine (PEA), but I was using copious amounts, sometimes for more than a day in a stretch.
-undopaminergic
Posted by SLS on February 21, 2023, at 14:30:10
In reply to Re: adderallXR: NEED help please..everyone » Jay2112, posted by undopaminergic on February 21, 2023, at 9:59:37
Great info. Thanks.
- Scott> Amphetamines can be neurotoxic. It's just not clear how much is too much.
>
> It appears extracellular dopamine can be converted to dopaquinones which cause oxidative stress, which can damage nerve terminals (which is from where the dopamine is released into the synapse). It happens in methamphetamine abuse, and I'm pretty sure it happened to me with phenylethylamine (PEA), but I was using copious amounts, sometimes for more than a day in a stretch.
>
> -undopaminergic
>
Posted by Jay2112 on February 21, 2023, at 21:32:07
In reply to Re: adderallXR: NEED help please..everyone » Jay2112, posted by undopaminergic on February 21, 2023, at 9:59:37
> >
> > ****WOULD TAKING 15MG OF ADDERALL (MIXED AMPHETAMINE SALTS) EVERY DAY FOR THE REST OF MY LIFE BE FINE??*****
> >
>
> Amphetamines can be neurotoxic. It's just not clear how much is too much.
>
> It appears extracellular dopamine can be converted to dopaquinones which cause oxidative stress, which can damage nerve terminals (which is from where the dopamine is released into the synapse). It happens in methamphetamine abuse, and I'm pretty sure it happened to me with phenylethylamine (PEA), but I was using copious amounts, sometimes for more than a day in a stretch.
>
> -undopaminergic
>Sorry for the shouting. I take 15mg of AdderallXR, and it is the ONLY thing so far (along with other forms of amphetamine) that touches my dx'ed ADD as well as a lift to my horrific depression. The thing is, I have extreme anxiety (GAD + Panic attacks) and the Adderall seems to help those things. (Well, the anxiety, anyways.) I REALLY have to be careful, as I do have psychosis (latent, so far). My pdoc is REALLY pushing Cariprazine, but my insurance doesn't cover it. I currently take 4mg of risperidone a day, and it helps cap psychosis and some anxiety/panic. I want to go back on haldol, but he is younger, and seems reluctant.
Any suggestions? Is the risperidone a neuro-protective factor in using Adderall? I actually did very well on Vyvanse, risperidone, and olanzapine. I might suggest that next.
Thanks,
Jay
Posted by Jay2112 on February 21, 2023, at 21:33:54
In reply to Re: adderallXR: NEED help please..everyone » undopaminergic, posted by SLS on February 21, 2023, at 14:30:10
Any comments, SLS? I always look forward to what you have to say.
Thanks,
Jay
Posted by undopaminergic on February 22, 2023, at 3:08:52
In reply to Re: adderallXR: NEED help please..everyone » undopaminergic, posted by Jay2112 on February 21, 2023, at 21:32:07
>
> Any suggestions? Is the risperidone a neuro-protective factor in using Adderall?
>No, in fact it could be the opposite, if it blocks dopamine autoreceptors, which would mean increased extracellular dopamine levels beyond what the amphetamines themselves produce.
On the other hand, it may serve to protect against psychotic reactions.
-undopaminergic
Posted by Jay2112 on February 23, 2023, at 15:15:03
In reply to Re: adderallXR: NEED help please..everyone, posted by NKP on February 19, 2023, at 9:50:17
> > Plus, I have Asperger's, and high serotonin levels can really fr*g things up!
>
> Why is that?Asperger's is a form of Autism. Autistic kids are born with a genetic sensitivity to serotonin.
Jay
Posted by SLS on February 23, 2023, at 18:15:58
In reply to Re: adderallXR: NEED help please..everyone » NKP, posted by Jay2112 on February 23, 2023, at 15:15:03
> > > Plus, I have Asperger's, and high serotonin levels can really fr*g things up!
> >
> > Why is that?
>
> Asperger's is a form of Autism. Autistic kids are born with a genetic sensitivity to serotonin.
>
> Jay
>Hi, Jay.
I think some experts on Asberger's now favor removing this disorder from the autistic spectrum.
- Scott
Posted by undopaminergic on February 24, 2023, at 10:07:22
In reply to Re: adderallXR: NEED help please..everyone » Jay2112, posted by SLS on February 23, 2023, at 18:15:58
> > > > Plus, I have Asperger's, and high serotonin levels can really fr*g things up!
> > >
> > > Why is that?
> >
> > Asperger's is a form of Autism. Autistic kids are born with a genetic sensitivity to serotonin.
> >
> > Jay
> >
>
> Hi, Jay.
>
> I think some experts on Asberger's now favor removing this disorder from the autistic spectrum.
>
>
> - ScottMy mother thinks I have Asperger's. I think schizoid personality disorder is a better fit.
-undopaminergic
Posted by TriedEveryMedication on March 9, 2023, at 20:49:12
In reply to Re: adderallXR: NEED help please..everyone » Jay2112, posted by undopaminergic on February 21, 2023, at 9:59:37
> >
> > ****WOULD TAKING 15MG OF ADDERALL (MIXED AMPHETAMINE SALTS) EVERY DAY FOR THE REST OF MY LIFE BE FINE??*****
> >
>
> Amphetamines can be neurotoxic. It's just not clear how much is too much.
>
> It appears extracellular dopamine can be converted to dopaquinones which cause oxidative stress, which can damage nerve terminals (which is from where the dopamine is released into the synapse). It happens in methamphetamine abuse, and I'm pretty sure it happened to me with phenylethylamine (PEA), but I was using copious amounts, sometimes for more than a day in a stretch.
>
> -undopaminergic
>Probably not at 15mg/day
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670101/
it takes a high abuse-level dose
Posted by Englishman006! on September 22, 2023, at 6:13:53
In reply to adderallXR: NEED help please..everyone, posted by Jay2112 on February 18, 2023, at 17:06:00
I've noticed a lot of people having problems have tranquillisers (clonazepam) in their cocktails. Don't get me wrong, they have their place but not long term. They can actually make you a lot worse. I tried Diazepam and it was great to start off with but then it became ordinary then I found symptoms coming back that I had as a teenager - not good!
They are hard to come off but that might be one source of your problems. They are good on an occasional basis when anxiety peaks. But maybe best avoided in the long run.
This is the end of the thread.
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