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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by PeterMartin on July 2, 2022, at 15:45:34
Has anyone ever taken Celebrex (drug name Celecoxib) for depression/anxiety or Bipolar related symptoms?
Aparently there has been some research over the years that it might be helpful in some cases.
https://pubmed.ncbi.nlm.nih.gov/30398124/
---
Abstract
Background: Bipolar Disorder (BD) is a psychiatric disorder characterized by mood disturbances. The pathophysiology of BD is still poorly understood. In the last years, research studies focused on the role of inflammation in BD.Objective: Performed a systematic review and meta-analysis to evaluate the potential effect of the cyclo- oxygenases (Cox)-2 inhibitor Celecoxib adjunct treatment in BD through randomized controlled trials (RCT).
Methods: A search on the electronic databases was proceeded, on MEDLINE, EMBASE, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), Biomed Central, Web of Science, IBECS, LILACS, PsycINFO, Congress Abstracts, and Grey literature (Google Scholar and the British Library) for studies published from January 1990 to February 2018. A search strategy was developed using the terms: "Bipolar disorder" or "Bipolar mania" or "Bipolar depression" or "Bipolar mixed" or "Bipolar euthymic" and "Celecoxib" or "Cyclooxygenase-2 inhibitors" or "Cox-2 inhibitors" as text words and Medical Subject Headings (i.e., MeSH and EMTREE) and searched. The therapeutic effects of adjunctive treatment with Celecoxib were analyzed. The meta-analysis was performed including the results of the Young Mania Rating Scale (YMRS) at the end of RCT.
Results: Three primary studies were included in the systematic review, with a total of 121 patients. The meta-analysis showed a significant effect on the YMRS scores from patients with BD who used Celecoxib adjuvant treatment in comparison to placebo.
Conclusion: The systematic review suggests that adjuvant treatment with Celecoxib improves the response of major treatments in patients with BD when compared with adjuvant placebo treatment. Systematic Review Registration Number: The review protocol was registered at PROSPERO (registration number: CRD42017067635); in June 06 2017.
Keywords: Bipolar disorder; Cox-2 inhibitors; celecoxib; hypomania; mania; meta-analysis; systematic review..
Posted by Christ_empowered on July 5, 2022, at 7:52:10
In reply to Celecoxib (Celebrex) for Bipolar depression?, posted by PeterMartin on July 2, 2022, at 15:45:34
this makes sense. thank you. :-)
I personally noticed that adding in astaxanthin and Pycnogenol lifted my mood, big time (I also have a DIY Orthomolecular thing going on...that's just vitamins and minerals, though).
not celebrex-level anti-inflammatory action, but...helpful, nonetheless.
thanks again.
Posted by SLS on July 5, 2022, at 15:15:54
In reply to Re: Celecoxib (Celebrex) for Bipolar depression?, posted by Christ_empowered on July 5, 2022, at 7:52:10
> this makes sense. thank you. :-)
>
> I personally noticed that adding in astaxanthin and Pycnogenol lifted my mood, big time (I also have a DIY Orthomolecular thing going on...that's just vitamins and minerals, though).
>
> not celebrex-level anti-inflammatory action, but...helpful, nonetheless.
>
> thanks again.
If you are attempting to treat yourself with a drug that reduces inflammation, monocycline might be worth looking into. It has been used as an antibiotic as that it is official indication. However, monocycline also acts as an anti-inflammatory in the brain via the inhibition of the secretion of pro-inflammatory cytokines by microglia.I was definitely moderately improved using monocycline, and the effect was sustained. I stopped taking it because hyperpigmentation emrged of the feet and ankles. It is not uncommon.
The results of the celecoxib studies I ran accoss were disappointing.
- Scott
Posted by linkadge on July 5, 2022, at 18:28:38
In reply to Re: Celecoxib (Celebrex) for Bipolar depression? » Christ_empowered, posted by SLS on July 5, 2022, at 15:15:54
Yeah. You want drugs that reduce microglial inflammation, not (if possible) shutting down inflammation in the entire body.
Activating the CB2 receptors is one strategy which is particularly effective for reducing microglial inflammation. Cannabis is a mish-mash of CB1 and CB2 agonists / antagonists. DHA (omega 3) produces a metabolite which is a selective CB2 agonist.
Some psych meds are better at others for reducing inflammation in the brain. Nortriptyline is particularly effective. Venlafaxine is too, to a lesser extent. The SSRIs have some mild effects, but often they do not 'normalize' increased markers of inflammation in depressed patients.
Linkadge
Posted by SLS on July 5, 2022, at 21:39:21
In reply to Re: Celecoxib (Celebrex) for Bipolar depression?, posted by linkadge on July 5, 2022, at 18:28:38
> Yeah. You want drugs that reduce microglial inflammation, not (if possible) shutting down inflammation in the entire body.
>
> Activating the CB2 receptors is one strategy which is particularly effective for reducing microglial inflammation. Cannabis is a mish-mash of CB1 and CB2 agonists / antagonists. DHA (omega 3) produces a metabolite which is a selective CB2 agonist.
>
> Some psych meds are better at others for reducing inflammation in the brain. Nortriptyline is particularly effective. Venlafaxine is too, to a lesser extent. The SSRIs have some mild effects, but often they do not 'normalize' increased markers of inflammation in depressed patients.
>
> LinkadgeYou never fail to amaze me, Linkadge. I have been taking nortriptyline for at least 5 years. It is the most effective of all the TCAs I have tried. The only one I missed is doxepin. Somebody said that doxepin was the strongest antihistamine on the market. Is this true? Also, what do you think of using quetiapine (Seroquel) for sleep? Diphenhydramine (Benadryl) makes me feel like crap. I experience malaise on it. Would Seroquel treat me equally bad?
Thanks.
- Scott
Posted by linkadge on July 6, 2022, at 9:22:51
In reply to Re: Celecoxib (Celebrex) for Bipolar depression? » linkadge, posted by SLS on July 5, 2022, at 21:39:21
I'd have to check the affinities but I think (for histamine)...
quetiapine < mirtazapine < doxapin < trimipramine
But, they're all very strong antihistamines. I agree, diphenhydramine makes me feel like crap too.
Nortriptyline has an interesting property in that it seems to prevent the aggregation of alpha synuclein (the clumps that contribute to Lewy bodies, Parkinson's and possibly dementia). You can google: nortriptyline + alpha synuclein for more info.
Linkadge
Posted by linkadge on July 6, 2022, at 9:25:47
In reply to Re: Celecoxib (Celebrex) for Bipolar depression? » linkadge, posted by SLS on July 5, 2022, at 21:39:21
Just to add:
It's a shame that pioglitazone (the ppar-gamma receptor agonists / anti diabetic drug) was taken off the market. The ppar-gamma receptors are also an target for reducing microglia inflammation.
Interestingly, pioglitazone was also a mao-b inhibitor.
Posted by SLS on July 7, 2022, at 0:21:49
In reply to Re: Celecoxib (Celebrex) for Bipolar depression?, posted by linkadge on July 6, 2022, at 9:25:47
This is the end of the thread.
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