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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by linkadge on September 16, 2021, at 19:49:00
Hi there,
I got my results from the 23ANDME test. I took the results to Prometheus and have spend a few days reading things over. For the most part, there were no 'glaring' issues but some interesting findings that I need to look further into.
1) I have the 'bad' version of the methfolate gene that 5-10% of the population possesses. I found this interesting as folic acid, methyfolate and SAMe have always had a degree of efficacy for me.
2) I may have a partial biotindase deficiancy. This apparently reduces the levels of biotin. I have never supplemented with biotin (in isolation) but may consider doing this, with further research
3) The SNPs tested for CACNA1 were normal, but I possess some 'rare' variants of the ANK3 genes. ANK3 genes are among the stronger associated genes for bipolar. I didn't have all the 'bad' genes, but (out of the 7 SNPs tested) I had 3 of the rare variants (where only 2-5% of the population possesses). I would like to get my mother and father tested to see if I got the 'bad' ones from my mother.
4) I didn't get a conclusive result on the serotonin transporter gene, but it's somewhat likely I have a L-S variant.
5) I didn't get any meaningful results on the MAO-A or COMT related genes.
6) My PER2 and PER3 genes were normal. I have had ongoing sleep issues so was hoping something would show up here, but it didn't.
7) I had one bad SNP in the DISC1 gene (linked to bipolar / schizophrenia), but other SNPs here were fine.
8) I got no meaningful information on TRKB, but the small number of BDNF SNPs looked fine.
9) In the 50 SNPs analyzed for bipolar, I had some uncommon ones show up. In other words, I had more 'bipolar' genes come up than would be expected by chance.
10) Unfortunately, 23ANDME didn't analyze many of the 'unipolar' SNPS (only 9) so I couldn't get much info is here.
So, all in all, I'm still reading on this. I didn't get any major breakthrough results BUT I did get some nuggets worth looking into (namely a possible need to supplement with methylfolate, biotin and that I seem to have some degree of bipolar genetic load).Linkadge
Posted by Lamdage22 on September 24, 2021, at 10:50:03
In reply to Genetic Testing Results, posted by linkadge on September 16, 2021, at 19:49:00
Are you considering supplements now as a result of your test?
Posted by SLS on September 25, 2021, at 8:53:47
In reply to Genetic Testing Results, posted by linkadge on September 16, 2021, at 19:49:00
Hi, Linkadge.
I forget where I read it, but Bipolar Disorder diagnostic criteria includes a presentation of chronic depression in the absence of a manic episode.
Have you ever been manic or hypomanic or suspect it?
Racing, but depressive thoughts? If so, you might qualify as Bipolar Disorder, mixed state. Do you have any of the DSM-5 specifiers for Bipolar Disorder?
Here's a gift if you don't have a copy already:
Give the manual a few seconds to begin downloading.
Go to page # 168.
I'll be curious to know what you come up with.
- Scott
Posted by SLS on September 25, 2021, at 9:26:04
In reply to Genetic Testing Results, posted by linkadge on September 16, 2021, at 19:49:00
Hi Linkadge:
Use these URL links instead:
This is the page with the DSM-5 and related books.https://www.pdfdrive.com/diagnostic-and-statistical-manual-of-mental-disorders-dsm-5-e157926175.html
.
.Direct links to download:
.
.PDF:
This is the end of the thread.
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