Psycho-Babble Medication Thread 1105899

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Does body weight influence psych med concentration

Posted by radish on August 24, 2019, at 20:34:08

Does body weight or biological sex influence the pharmacokinetics and pharmacodynamics of psychotropic drugs? Would a given dose have different concentrations in lower and higher body weight individuals? I am interested in this topic but did not find straightforward answers online. Does anyone have any info?

Radish

 

Re: Does body weight influence psych med concentration

Posted by TH on August 25, 2019, at 7:10:40

In reply to Does body weight influence psych med concentration, posted by radish on August 24, 2019, at 20:34:08

The answer is yes, body weight would have an effect. Medication dose is sometimes given as mg/Kg for this reason (milligrams of substance per kg of body weight)

That being said, very rarely are we precise enough with with our dosing for +/- a few % in mg/Kg dose to be of much consequence.

 

Re: Does body weight influence psych med concentration TH

Posted by linkadge on August 25, 2019, at 11:05:54

In reply to Re: Does body weight influence psych med concentration, posted by TH on August 25, 2019, at 7:10:40

A big factor (probably bigger than weight) is genetic differences in liver enzymes. This can have a difference on level of drug and/or active metabolites.

Really, unless one is using therapeutic monitoring (say Depakote, lithium or nortriptyline) the dose should not be a specific target IMHO. Some people do well on low doses, some need higher doses.

Linkadge


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