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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by joe f on June 20, 2019, at 9:52:14
what is the real difference in these drugs.......pharm reps are pushing rexulti but my PA says there is only a slight difference.
Posted by rjlockhart37 on June 20, 2019, at 13:45:41
In reply to rexulti/abilify what is the real difference, posted by joe f on June 20, 2019, at 9:52:14
abilify hits D2 receptors more than rexulti, that's why its a bit more stimulating than rexulti
Posted by Christ_empowered on June 20, 2019, at 19:38:09
In reply to rexulti/abilify what is the real difference, posted by joe f on June 20, 2019, at 9:52:14
rexulti can raise prolactin levels. abilify can lower prolactin levels. abilify doses usually go up to 30mgs/daily. I think the rexulti doses are lower and there are fewer pill size options, right now.
i read somewhere...probably wiki, maybe somewhere else...that the eps stats for rexulti aren't so encouraging. that's probably full dose, not low dose.
Posted by joe f on June 21, 2019, at 10:17:07
In reply to Re: rexulti/abilify what is the real difference, posted by Christ_empowered on June 20, 2019, at 19:38:09
WHAT ARE EPS STATS......SO YOU HINK ABILIFY MAY BE MORE STIMULATING?
Posted by Christ_empowered on June 21, 2019, at 10:46:09
In reply to Re: rexulti/abilify what is the real difference, posted by joe f on June 21, 2019, at 10:17:07
eps covers adverse effects such as stiff gait, Parkinsonism, muscle rigidity, etc. I think akathisia is tracked as a category in its own right.
problem with a rough eps profile in an 'atypical' is that it might mean a higher rate of tardive syndromes down the road. the other thing is...
initially, the primary selling point of the 'atypicals' was to control psychosis, mania without (as much) EPS. kinda didn't pan out...low to moderate doses of the older drugs can do the job with less EPS than expected, if the agent is selected carefully (read: low to mid potency, avoid Haldol like the plague), but...
the 'atypicals' do have some beneficial effects on mood, or at least (for me and a lot of other people) they don't push down into depression, cause dysphoric reactions, etc.
im kinda wondering why your doctor won't just try abilify, at a low to moderate dose...there's a whole lot more data available on abilify than rexulti.
Posted by joe f on June 21, 2019, at 10:50:25
In reply to Re: rexulti/abilify what is the real difference, posted by Christ_empowered on June 21, 2019, at 10:46:09
was on abilify put to much weight on......so far none on rexulti which is more likely to increase dopamine and which is more likely to increase parkins like symptoms
Posted by Christ_empowered on June 22, 2019, at 17:53:40
In reply to Re: rexulti/abilify what is the real difference, posted by joe f on June 21, 2019, at 10:50:25
i dunno man. rexulti is -very- new, there's only limited data on it. i think its the one that goes for the D3 receptors...unless that's vraylar...
sorry. :-( if it works and you've got insurance coverage, I guess stick with it (?). do you need an antipsychotic? i mean...lots of people are given the tranquilizers who could do without them, possibly. maybe. its gotten worse w/ the 'atypicals'...now and everybody and their mama is on one.
have you had an AIMS evaluation? i think nurses can do them, too. not to scare you or anything, but the neuroleptics cause TD (obviously), but they also suppress the movements, at least for a while...
which is 1 reason why once TD is formally diagnosed, people are stuck with it. well...that and slack psych pros.
sorry. with TD, the risk goes up with cumulative exposure. so, your lifetime exposure to neuroleptics, old and new, adds up, and that plays a big role in who does and does not develop TD. low doses should = lower risk, but there's lots of unknown factors that come into play, too.
not trying to be bummer bob. i take loads of antioxidants w/ my neuroleptic, and so far, so good...0 eps, 0 td, even the dysphoric 'blah' feeling is a lot better. just thought id mention that.
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