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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 25. This is the beginning of the thread.
Posted by Lamdage22 on June 5, 2019, at 8:36:19
Hey guys,
does anyone know anything about SAGE-217? When will it come out? Are there any interactions? Is it neutral or helpful in regard to anxiety? What about driving and operating machines?
Kind of desperate once again!
Posted by Hugh on June 5, 2019, at 22:48:55
In reply to SAGE-217, posted by Lamdage22 on June 5, 2019, at 8:36:19
> does anyone know anything about SAGE-217? When will it come out? Are there any interactions? Is it neutral or helpful in regard to anxiety? What about driving and operating machines?
It's likely that the FDA will approve Sage-217 for postpartum depression by this fall. If this happens, it will probably take a few months for it to reach pharmacy shelves. Any physician in the US will be able to prescribe it off-label for depression, anxiety, insomnia, PTSD.
Since Sage-217 appears to reboot GABA-A receptors, it should be quite helpful for anxiety.
In the clinical trials, many of those taking it for 14 days had their depression go into remission for at least 30 days after they stopped taking it, and possibly much longer.
Posted by sigismund on June 5, 2019, at 23:52:08
In reply to Re: SAGE-217, posted by Hugh on June 5, 2019, at 22:48:55
>Since Sage-217 appears to reboot GABA-A receptors, it should be quite helpful for anxiety.
Interesting. Can you say more, Hugh?
Posted by Hugh on June 6, 2019, at 12:27:45
In reply to Re: SAGE-217 » Hugh, posted by sigismund on June 5, 2019, at 23:52:08
Sage-217 works on a different part of the GABA-A receptor than benzodiazepines. And taking it for 14 days seems to get the receptors to function better long-term, for many, and perhaps even permanently, for some. They've only followed up for 30 days after the clinical trials, so only time will tell how long its effects last.
The following is from Sage's website:
The GABA system is the major inhibitory signaling pathway of the central nervous system (CNS), and contributes significantly to regulating CNS function. SAGE-217 is a novel, highly potent and selective, next generation GABAA receptor positive allosteric modulator that is being developed as a once-daily, oral therapy for the treatment of various CNS disorders.
Complete article:
Here's a Q&A session transcript from Sage Therapeutics:
https://investor.sagerx.com/static-files/e269a056-a358-4120-8302-5b6ce278ba19
Posted by beckett2 on June 6, 2019, at 23:16:50
In reply to Re: SAGE-217, posted by Hugh on June 5, 2019, at 22:48:55
Really? Postpartum depression because it's fast acting?
> > does anyone know anything about SAGE-217? When will it come out? Are there any interactions? Is it neutral or helpful in regard to anxiety? What about driving and operating machines?
>
> It's likely that the FDA will approve Sage-217 for postpartum depression by this fall. If this happens, it will probably take a few months for it to reach pharmacy shelves. Any physician in the US will be able to prescribe it off-label for depression, anxiety, insomnia, PTSD.
>
> Since Sage-217 appears to reboot GABA-A receptors, it should be quite helpful for anxiety.
>
> In the clinical trials, many of those taking it for 14 days had their depression go into remission for at least 30 days after they stopped taking it, and possibly much longer.
>
Posted by Hugh on June 7, 2019, at 18:45:22
In reply to Re: SAGE-217 » Hugh, posted by beckett2 on June 6, 2019, at 23:16:50
Sage-217 is the pill version of brexanolone. The IV version of this drug, Zulresso, was approved by the FDA a few months ago. It's the first drug ever approved for postpartum depression. One of its advantages is that it starts to work within days, not weeks. There are also clinical trials underway for Sage-217 and major depressive disorder, insomnia, and bipolar depression.
Posted by SLS on June 7, 2019, at 19:12:06
In reply to Re: SAGE-217 » beckett2, posted by Hugh on June 7, 2019, at 18:45:22
> Sage-217 is the pill version of brexanolone. The IV version of this drug, Zulresso, was approved by the FDA a few months ago. It's the first drug ever approved for postpartum depression. One of its advantages is that it starts to work within days, not weeks. There are also clinical trials underway for Sage-217 and major depressive disorder, insomnia, and bipolar depression.
Clinical trials of Sage-217 (zuranolone) for Major Depressive Disorder have been underway for awhile. The company might be looking at it for bipolar depression as well.
- Scott
Posted by Lamdage22 on June 8, 2019, at 6:19:17
In reply to Re: SAGE-217, posted by SLS on June 7, 2019, at 19:12:06
Hi Scott, how are you holding up? Will you try Zulresso or SAGE-217?
Posted by Ruuudy on June 9, 2019, at 17:41:58
In reply to Re: SAGE-217, posted by Lamdage22 on June 8, 2019, at 6:19:17
Where's the "LIKE" button?!?
Hoping to hear more good stuff about this drug!
Rudy
Posted by sigismund on June 9, 2019, at 18:47:21
In reply to Re: SAGE-217, posted by Ruuudy on June 9, 2019, at 17:41:58
From the little I know I would give it a go.
Posted by Lamdage22 on June 10, 2019, at 2:22:01
In reply to Re: SAGE-217, posted by sigismund on June 9, 2019, at 18:47:21
Me too. Its a shame that Rapastinel failed. It looked so promising. Also i am looking into Aloradine.
Posted by SLS on June 10, 2019, at 19:28:55
In reply to Re: SAGE-217, posted by Lamdage22 on June 8, 2019, at 6:19:17
> Hi Scott, how are you holding up? Will you try Zulresso or SAGE-217?
I would not hesitate to try SAGE-217 (zuranolone). It is very different from anything currently available.
I have had some brief improvements from taking Trintellix. I think my doctor was right about lower dosages being better than higher dosages. I'll let you know in a week.
- Scott
Posted by SLS on June 10, 2019, at 19:33:03
In reply to Re: SAGE-217, posted by Lamdage22 on June 10, 2019, at 2:22:01
> Me too. Its a shame that Rapastinel failed. It looked so promising. Also i am looking into Aloradine.
You come up with good ones, Lamdage. Thanks for posting them.
- Scott
Posted by sigismund on June 10, 2019, at 23:34:58
In reply to Re: SAGE-217 » Lamdage22, posted by SLS on June 10, 2019, at 19:28:55
This is about Trintellix.
Did you get the nausea? Any other side effects?
Anything more to add?
Posted by PeterMartin on June 11, 2019, at 0:44:01
In reply to SAGE-217, posted by Lamdage22 on June 5, 2019, at 8:36:19
Investors seem to think the company behind this (SAGE) has an upside. They're working on other novel medicines for CNS stuff that sound interesting also. From an article posted today (June 10, 2019):
Sage Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops and commercializes novel medicines to treat central nervous system (CNS) disorders. Its lead product candidate is ZULRESSO, a proprietary intravenous formulation of brexanolone that has completed Phase III clinical trials for the treatment of postpartum depression (PPD). The companys product pipeline also includes SAGE-217, a novel neuroactive steroid, which is in Phase III clinical trials for treating PPD, major depressive disorders, bipolar depression, and sleep disorders; and SAGE-324, a novel neuroactive steroid that has completed Phase I clinical trials to treat various neurological conditions, including essential tremor and epileptiform disorders. In addition, its product pipeline comprises SAGE-718, an oxysterol-based positive allosteric modulator of the NMDA receptor, which has completed Phase I clinical trial for the treatment of depression, Huntingtons disease, Alzheimers disease, attention deficit hyperactivity disorder, schizophrenia, and neuropathic pain; and SAGE-689, a novel GABAA receptor positive allosteric modulator that is in preclinical stage to treat acute and chronic CNS disorders. Sage Therapeutics, Inc. has a strategic collaboration with Shionogi & Co., Ltd. for the development and commercialization of SAGE-217 in Japan, Taiwan, and South Korea. The company was formerly known as Sterogen Biopharma, Inc. and changed its name to Sage Therapeutics, Inc. in September 2011. Sage Therapeutics, Inc. was founded in 2010 and is headquartered in Cambridge, Massachusetts.
Posted by Lamdage22 on June 11, 2019, at 10:04:52
In reply to Re: SAGE-217, posted by PeterMartin on June 11, 2019, at 0:44:01
Its good that they are working on stuff. But the other ones are far far away from making it onto the market
Posted by Lamdage22 on June 25, 2019, at 21:24:40
In reply to Re: SAGE-217 » Lamdage22, posted by SLS on June 10, 2019, at 19:28:55
So Scott,
how is it going? Will you hold on to Trintellix? Did your weight and metabolic issues improve? Do you still take a Neuroleptic?
Posted by SLS on June 28, 2019, at 8:51:43
In reply to Re: SAGE-217, posted by Lamdage22 on June 25, 2019, at 21:24:40
> So Scott,
>
> how is it going? Will you hold on to Trintellix? Did your weight and metabolic issues improve? Do you still take a Neuroleptic?
>
>I haven't taken Abilify in over a year. However, I am not ruling out restarting it. I could try returning to prazosin also. I don't like the idea of doing either, so I will wait a bit longer.
I am my own worst enemy. I pushed the dosage of Trinellix to 20 mg/day - again. Within a few days, I was beset by dysphoria, anxiety, and a paralyzing amotivation. The base depression was not worsened, though. I can tell the difference. I am not ready to abandon Trintellix yet. I'll give 15 mg/day more time to work. I can't afford to be ill and non-functional right now. My mother has dementia and is deteriorating rapidly. I have two siblings, neither of whom have been helping me take care of her. She is still living in her house, but I don't know how much longer she can stay there.
- Scott
Posted by Lamdage22 on June 28, 2019, at 13:44:33
In reply to Re: SAGE-217, posted by SLS on June 28, 2019, at 8:51:43
I am sorry to hear that Scott. My Grandma has dementia and she has been in a nursing home for a few months. It would take the whole family living together in order for her to not be in the nursing home and that won't happen.
>My mother has dementia and is deteriorating rapidly. I have two siblings, neither of whom have been helping me take care of her. She is still living in her house, but I don't know how much longer she can stay there.
Posted by sigismund on June 29, 2019, at 2:32:18
In reply to Re: SAGE-217, posted by SLS on June 28, 2019, at 8:51:43
>I could try returning to prazosin also. I don't like the idea of doing either,
Why not prazosin, Scott?
Posted by Lamdage22 on June 29, 2019, at 3:09:32
In reply to Re: SAGE-217 » SLS, posted by sigismund on June 29, 2019, at 2:32:18
From the outside, it looks like what you were on previously wasn't so bad. Of course, you have to know what's good for you. I am thinking of going 37,5->75mg Venlafaxine. Although I have an easy going doctor I won't do it without consulting him first though.
Posted by Lamdage22 on June 29, 2019, at 3:22:59
In reply to Re: SAGE-217, posted by Lamdage22 on June 29, 2019, at 3:09:32
Obviously, it wasn't good enough. Otherwise, you would be on it. Sorry about that. I think eventually science will bring out something good it just takes a couple more years. That can seem like a really long time if you are too depressed. I am improved to the point where I can function good enough to master most areas of my life. My next big quest is studying English-German translation online in August.
A big problem of mine is overreacting to my surroundings. I think that is deeply rooted in my psyche. I have made bad experiences early in life and now all I see is that people are out to get me!
Posted by Lamdage22 on June 29, 2019, at 3:26:30
In reply to Re: SAGE-217, posted by Lamdage22 on June 29, 2019, at 3:22:59
Always think they will abandon and humiliate me.
Posted by SLS on June 29, 2019, at 14:21:19
In reply to Re: SAGE-217 » SLS, posted by sigismund on June 29, 2019, at 2:32:18
> >I could try returning to prazosin also. I don't like the idea of doing either,
>
> Why not prazosin, Scott?I did not like the loss of sex drive with prazosin. Thinking about it, I guess it wouldn't make any difference now since I currently have no libido with Trintellix. Prazosin might have caused me to put on some weight, but it would be difficult to parse the relative contributions of prazosin with Abilify. Otherwise, I find prazosin to be a very clean drug. If I remain disappointed in Trintellix in two weeks, I will probably restart prazosin.
- Scott
Posted by Lamdage22 on June 30, 2019, at 6:03:48
In reply to Re: SAGE-217 » sigismund, posted by SLS on June 29, 2019, at 14:21:19
Thats understandable. I can imagine that low libido is better than high libido coupled with erectile dysfunction and/or anorgasmia. I hated that.
This is the end of the thread.
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