Psycho-Babble Medication Thread 1096070

Shown: posts 1 to 10 of 10. This is the beginning of the thread.

 

Schizophrenia begins in the womb

Posted by Hugh on November 26, 2017, at 13:36:23

Symptoms of schizophrenia usually appear in adolescence or young adulthood, but new research reveals that the brain disease likely begins very early in development, toward the end of the first trimester of pregnancy. The finding opens up a new understanding of this devastating disease and the potential for new treatment possibilities in utero.

"The next step is to investigate how to target the INFS pathway and even other pathways that interact with INFS using drugs or even dietary supplements that could prevent the dysregulation from taking place," he [Michal K. Stachowiak] continued, noting that this kind of supplementation has been effective with disorders such as spina bifida, for example.

Complete article:

https://medicalxpress.com/news/2017-11-schizophrenia-early-pregnancy-mini-brain.html

Robert Freedman of the University of Colorado, Denver has been giving the dietary supplement phosphatidylcholine to pregnant women, and has found that this may significantly lower the risk of their children developing schizophrenia.

https://www.livescience.com/52674-prenatal-choline-schizophrenia-risk.html

Dr. Freedman's talk on preventing schizophrenia:

https://www.youtube.com/watch?v=J4ZUMgLAryU

In a clinical trial that Dr. Freedman is conducting, he instructs pregnant women to take five 450 mg phosphatidylcholine capsules at breakfast and five 450 mg phosphatidylcholine capsules at dinner. This is the equivalent of approximately 1250 mg of choline per day. To get this amount of choline through diet alone, a person would have to eat six eggs a day.

And animal research suggests that extra choline during pregnancy produces offspring that are less likely to suffer from depression, anxiety, low intelligence, and memory loss later in life.

 

Re: Schizophrenia begins in the womb

Posted by Hugh on December 1, 2017, at 15:01:07

In reply to Schizophrenia begins in the womb, posted by Hugh on November 26, 2017, at 13:36:23

The alpha-7 nicotinic receptor is responsible for some cases of autism, bipolar disorder, ADHD, schizophrenia, and severe developmental disorders. Robert Freedman says that, by taking phosphatidylcholine during pregnancy, women could reduce the risk of their children being afflicted with these illnesses.

 

Re: Schizophrenia begins in the womb

Posted by SLS on December 1, 2017, at 21:22:09

In reply to Re: Schizophrenia begins in the womb, posted by Hugh on December 1, 2017, at 15:01:07

> The alpha-7 nicotinic receptor is responsible for some cases of autism, bipolar disorder, ADHD, schizophrenia, and severe developmental disorders. Robert Freedman says that, by taking phosphatidylcholine during pregnancy, women could reduce the risk of their children being afflicted with these illnesses.

Thanks for the information.

Where does Wellbutrin fit in, if at all?


- Scott

 

Re: Schizophrenia begins in the womb SLS

Posted by Hugh on December 2, 2017, at 13:11:45

In reply to Re: Schizophrenia begins in the womb, posted by SLS on December 1, 2017, at 21:22:09

Interesting question. Since Wellbutrin is a nicotinic receptor antagonist, and Robert Freedman is experimenting with choline, a selective agonist of the alpha-7 nicotinic acetylcholine receptor, is it possible that taking Wellbutrin during pregnancy could increase the risk of these offspring being afflicted with schizophrenia, bipolar disorder, autism, ADHD, and severe developmental disorders?

 

Re: Schizophrenia begins in the womb Hugh

Posted by Phillipa on December 2, 2017, at 17:36:24

In reply to Re: Schizophrenia begins in the womb SLS, posted by Hugh on December 2, 2017, at 13:11:45

So many warning on on the medical news letters I get of the dangers of too high a dose of choline what was thought to be a part of the B vitamine complex. Phillipa

 

Re: Schizophrenia wong answer posted by self above

Posted by Phillipa on December 2, 2017, at 17:43:29

In reply to Re: Schizophrenia begins in the womb Hugh, posted by Phillipa on December 2, 2017, at 17:36:24

https://www.npr.org/sections/health-shots/2016/10/22/498843225/can-mental-illness-be-prevented-in-the-womb

 

Re: Schizophrenia begins in the womb Phillipa

Posted by Hugh on December 4, 2017, at 11:00:35

In reply to Re: Schizophrenia begins in the womb Hugh, posted by Phillipa on December 2, 2017, at 17:36:24

It's difficult to overdose on choline. It takes about 10,000 mg to do so. Dr. Freedman instructs pregnant women to take 4,500 mg of phosphatidylcholine a day, which is the equivalent of 1,250 mg of choline.

 

Re: Schizophrenia begins in the womb Hugh

Posted by Phillipa on December 4, 2017, at 17:34:49

In reply to Re: Schizophrenia begins in the womb Phillipa, posted by Hugh on December 4, 2017, at 11:00:35

Wouldn't it be something if something as simple as a part of a B vitamin could stop Scizophrenia from happening? Phillipa

 

Re: Schizophrenia begins in the womb

Posted by Hugh on December 7, 2017, at 13:11:33

In reply to Schizophrenia begins in the womb, posted by Hugh on November 26, 2017, at 13:36:23

[Stephen] Zeisel said our choline intake started to drop in the 1970s with the advice to reduce dietary cholesterol. "Many adults are avoiding foods that contain choline because they are avoiding cholesterol. It gets a lot harder to get enough choline if you're not drinking milk and eating eggs and meat."

Recent research suggests that only 8.5 percent of pregnant women meet the daily choline recommendations, but as of last year, none of the top 25 prenatal multivitamins contained the recommended 450 mg dose of choline for pregnant women. This prompted the American Medical Association (AMA) to recently call for increasing the amount of choline in prenatal vitamins.

Complete article:

https://www.seattletimes.com/life/wellness/choline-the-essential-but-forgotten-nutrient/

 

Re: Schizophrenia begins in the womb

Posted by Hugh on December 16, 2017, at 14:40:03

In reply to Schizophrenia begins in the womb, posted by Hugh on November 26, 2017, at 13:36:23

Most prenatal vitamins have too much folic acid (which can increase the risk of autism) and none of them have enough choline. Dr. Tod Cooperman recommends taking no more than 400 mcg of folic acid per day during pregnancy, and most prenatal vitamins contain 800 mcg.

"Researchers [at Johns Hopkins University] found that if a new mother has a very high level of folate right after giving birth -- more than four times what is considered adequate -- the risk that her child will develop a condition on the autism spectrum doubles. Very high vitamin B12 levels in new moms are also potentially harmful, tripling the risk that her offspring will develop an autism spectrum disorder. If both levels are extremely high, the risk that a child develops the condition increases 17.6 times."

Complete article about the Johns Hopkins study:

https://hub.jhu.edu/2016/05/12/too-much-folate-pregnant-autism/

It's also important for pregnant women to supplement with iodine. Even though salt in the US has been iodized since 1924, Americans' iodine intake has fallen dramatically because fast foods and processed foods are made with salt that isn't iodized, and kosher salt isn't iodized, and sea salt usually isn't iodized. So 80% of the salt Americans consume is not iodized. Dr. Cooperman recommends 150 mcg of iodine per day from a supplement, plus more from your diet.

He recommends 27 mg of iron per day during pregnancy. B vitamins are also important during pregnancy, but be very careful not to get too much B12 or folic acid.

Dr. Cooperman can't recommend any brand of prenatal vitamins, because all of them are so far behind the science. So pregnant women might be better off taking a regular multivitamin that contains 150 mcg of iodine, 27 mg of iron, and no more than 400 mcg of folic acid, and then taking a separate choline supplement (phosphatidylcholine is best).

Here is Dr. Cooperman's talk on prenatal vitamins:

https://www.youtube.com/watch?v=l2jVql5NDac


This is the end of the thread.


Show another thread

URL of post in thread:


Psycho-Babble Medication | Extras | FAQ


[dr. bob] Dr. Bob is Robert Hsiung, MD, bob@dr-bob.org

Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.