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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Hugh on January 29, 2015, at 15:45:33
The PET scans showed significant inflammation in the brains of the people with depression, and the inflammation was most severe among the participants with the most severe depression. The brains of people who were experiencing clinical depression exhibited an inflammatory increase of 30%.
Complete article:
Posted by Phillipa on January 29, 2015, at 17:41:58
In reply to New depression + inflammation study, posted by Hugh on January 29, 2015, at 15:45:33
Hugh other than meds such a motrin what are other options as have always believed that inflammation causes lots of other things as well. Base on a dental proceedure where I was taking 800mg of Motrin for one day & the next day felt the best had in years. Thanks Phillipa
Posted by Tomatheus on January 29, 2015, at 21:36:14
In reply to New depression + inflammation study, posted by Hugh on January 29, 2015, at 15:45:33
Thank you for posting this article, Hugh. I'd like to point out that the discussion regarding the causality of the relationship between depression and inflammation didn't seem to take into account that there could be outside variables that elevate both inflammation and depression -- the article only seemed to hint at inflammation causing depression and depression causing inflammation as possibilities. There is some evidence, for example, to suggest that vitamin D might reduce inflammation, and with low vitamin D levels being correlated with depression and one review suggesting that vitamin D supplementation improves depression, I think there's a possibility that low vitamin D might be one variable that could cause both inflammation and depression. This, of course, is just a hypothesis of mine, and more research needs to be done to confirm whether the idea I put forth about low vitamin D causing both inflammation and depression has anything to it, but I wanted to point out that there are other possibilities besides "depression might cause inflammation" and "inflammation might cause depression." Something else could be causing them both.
Tomatheus
Posted by Hugh on January 31, 2015, at 10:24:25
In reply to Re: New depression + inflammation study » Hugh, posted by Phillipa on January 29, 2015, at 17:41:58
> Hugh other than meds such a motrin what are other options as have always believed that inflammation causes lots of other things as well. Base on a dental proceedure where I was taking 800mg of Motrin for one day & the next day felt the best had in years. Thanks Phillipa
There are studies showing that anti-inflammatories such as ibuprofen and aspirin can increase the effectiveness of ADs. And a recent study found that ibuprofen expands the lifespan of nematodes by 15%.
http://medicalxpress.com/news/2014-12-ibuprofen-anti-aging-medicine-popular-over-the.html
But of course ibuprofen and aspirin can cause ulcers if used regularly. There are some very potent, safe (apparently) anti-inflammatories in the pipeline. One of them is NOSH-aspirin.
You asked about ways other than meds to reduce inflammation. MSM has helped my sciatica a lot. You might want to investigate earthing.
http://www.drbriffa.com/2012/04/18/earthing-important-discovery-or-mumbo-jumbo/
Posted by Phillipa on January 31, 2015, at 19:27:42
In reply to Re: New depression + inflammation study » Phillipa, posted by Hugh on January 31, 2015, at 10:24:25
Hugh thanks. I wonder if for now 200mg a day of motrin would help. More interesting to me is that the l0 days was on augmentin for bronchitis not only did the bronchitis resolve, but other issues. So have to wonder if some bacteria left from lymes still there also. Phillipa
Posted by hello123 on February 1, 2015, at 0:58:24
In reply to Re: New depression + inflammation study » Phillipa, posted by Hugh on January 31, 2015, at 10:24:25
Minocycline,an antibiotic, has potent anti-inflammation properties. heres a good article on it.
Only one-third of patients undergoing monotherapy with an antidepressant achieve remission of their depressive symptoms and gain functional recovery. Therefore, further exploration of antidepressant mechanisms of action is important in order to facilitate the development of antidepressants with new modes of action. Preclinical and clinical studies have demonstrated that major depression is associated with impaired inflammatory responses and deficient neuroprotection. In this regard, we propose that the second-generation tetracycline "minocycline" may hold a potential as a new treatment for major depression. Emerging findings in animal and human studies of minocycline reveal that it has antidepressant-like neuroprotective and anti-inflammatory actions, and minocycline has been shown to perform as an antidepressant in an accepted animal model (forced swimming test). Anecdotal evidence supports minocycline's efficacy for augmentation of antidepressants in major depressive disorder. The following review describes the evidence supporting the consideration of minocycline as a potential antidepressant. We suggest that minocycline may be particularly helpful in patients with depression and comorbid cognitive impairment, as well as depression associated with organic brain disease. We also describe the antinociceptive effect of minocycline and propose a role for minocycline in the treatment of patients with major depression and prominent somatic discomfort and somatoform spectrum disorders. The lack of clinical studies of minocycline for depression is noted. Further studies of the potential therapeutic mechanism of minocycline and its therapeutic implications for major depression are warranted, and may substantially contribute to the development of newer and more effective antidepressants.
Posted by phidippus on February 10, 2015, at 14:38:04
In reply to New depression + inflammation study, posted by Hugh on January 29, 2015, at 15:45:33
"The Duke team concluded that depression, therefore, is more likely to contribute to inflammation in the body as opposed to arising as a consequence of inflammation."
Eric
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