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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by SLS on October 12, 2012, at 23:49:30
"The activity of a single gene sets in motion some of the brain changes seen in depression, according to a new study. The finding suggests a promising target for potential therapies."
http://www.nih.gov/researchmatters/september2012/09102012depression.htm
Paraphrase:
Some genes function to control the activity of other genes. It seems that this one GATA1 gene controls the activity of 5 other genes. GATA1 turns these genes off. When these 5 genes are turned off by excessive GATA1 activity, processes that support synapse formation are impaired, and major depressive disorder (MDD) is the result. Evidence for this has been collected from post-mortem studies of humans and live studies of rats. Understanding this genetic pathway might lead to the designing of drugs with novel biological targets to treat MDD.
- Scott
Posted by phillipa on October 13, 2012, at 9:17:35
In reply to Hope for the future?, posted by SLS on October 12, 2012, at 23:49:30
Knowledge may be there but are the funds? I'd like to think that health will become a priority. But it seems to be taking a back seat with the economy. I also found the same research in your article concerning taste & small. Seems it's true that some antibiotics and other meds can eliminate it. So I guess the biaxin xl that the infection control doc said was correct. Also true about sugar. Never ate before now 12 truffles a night which can no longer taste either. It relates to this as it's a cause of depression so what I knew is confirmed. Phillipa
Posted by SLS on October 13, 2012, at 10:04:14
In reply to Re: Hope for the future? » SLS, posted by phillipa on October 13, 2012, at 9:17:35
> Knowledge may be there but are the funds? I'd like to think that health will become a priority. But it seems to be taking a back seat with the economy. I also found the same research in your article concerning taste & small. Seems it's true that some antibiotics and other meds can eliminate it. So I guess the biaxin xl that the infection control doc said was correct. Also true about sugar. Never ate before now 12 truffles a night which can no longer taste either. It relates to this as it's a cause of depression so what I knew is confirmed. Phillipa
Perhaps I misunderstand you.
I disagree with the supposition that sugar and infection are the causes of MAJOR DEPRESSIVE DISORDER (MDD). That these things you describe may make people feel depressed and lethargic is not in dispute. They can. However, we are talking about a specific syndrome defined as MDD, a biological condition that exhibits biomarkers as well as well as symptom clusters.
- Scott
Posted by Phil on October 13, 2012, at 15:05:42
In reply to Re: Hope for the future? » phillipa, posted by SLS on October 13, 2012, at 10:04:14
Life in 2030 Dr Kaku
http://www.youtube.com/watch?v=219YybX66MYThe tech that's around the corner is amazing. Computer on a contact lens? Already working on it.
With what they are working on the possibilities seem unlimited and who knows what they can use or develop for MI. If 50 years or less people will be saying about us what we now say about lobotomies. Interesting video.
Posted by ChicagoKat on October 13, 2012, at 15:10:03
In reply to Hope for the future?, posted by SLS on October 12, 2012, at 23:49:30
> "The activity of a single gene sets in motion some of the brain changes seen in depression, according to a new study. The finding suggests a promising target for potential therapies."
>
> http://www.nih.gov/researchmatters/september2012/09102012depression.htm
>
> Paraphrase:
>
> Some genes function to control the activity of other genes. It seems that this one GATA1 gene controls the activity of 5 other genes. GATA1 turns these genes off. When these 5 genes are turned off by excessive GATA1 activity, processes that support synapse formation are impaired, and major depressive disorder (MDD) is the result. Evidence for this has been collected from post-mortem studies of humans and live studies of rats. Understanding this genetic pathway might lead to the designing of drugs with novel biological targets to treat MDD.
>
>
> - ScottThanks for sharing Scott...they are farther along with this than I had hoped for.
And Scott, you truly are a genius...passing on info on epigenetic research, I am much impressed.
Kat
Posted by ChicagoKat on October 13, 2012, at 15:12:56
In reply to Re: Hope for the future? » SLS, posted by Phil on October 13, 2012, at 15:05:42
> Life in 2030 Dr Kaku
> http://www.youtube.com/watch?v=219YybX66MY
>
> The tech that's around the corner is amazing. Computer on a contact lens? Already working on it.
>
> With what they are working on the possibilities seem unlimited and who knows what they can use or develop for MI. If 50 years or less people will be saying about us what we now say about lobotomies. Interesting video.I agree with you Phil....in 50yrs or so they will probably find today's practices as abhorrent as we now find those of the past.
Just wish I could be alive when they have found a real solution.
Kat
Posted by Phil on October 13, 2012, at 17:08:01
In reply to Re: Hope for the future? » Phil, posted by ChicagoKat on October 13, 2012, at 15:12:56
I've always really wished I could travel through time. I would love, and be freaked out, to see what is happening in 200 years. I've spent hours thinking about it.
Would anything be recognizable? What would we dress like? Would we be speaking Chinese :), would the planet be here? What would the population be? Would we be paying tons of money for water if there was any? I guess we would be dead in that case.If anyone has ideas I'd love to hear them.
Posted by phillipa on October 13, 2012, at 23:54:40
In reply to Re: Hope for the future? » phillipa, posted by SLS on October 13, 2012, at 10:04:14
Scott poorly worded by me. Yes loss of taste and smell and illness can lead to depression. Phillipa
Posted by phillipa on October 13, 2012, at 23:57:21
In reply to Re: Hope for the future? » ChicagoKat, posted by Phil on October 13, 2012, at 17:08:01
Phil remember when people talked of freezing their bodies and coming back when a solution to what they were deceased from had been found? We could build a big freezer and wait there. Phillipa
Posted by bleauberry on October 14, 2012, at 5:03:01
In reply to Hope for the future?, posted by SLS on October 12, 2012, at 23:49:30
I remember reading somewhere on pubmed how zyprexa turned on/up certain genes, and simultaneously turned off/down others. So I think the idea that genes are involved in depression is highly consistent and true. In some cases it may be what the drug is doing to the genes is more important than what the drug is doing to the neurotransmitters. And that's why I sometimes think it is important to think outside the box, try stuff that maybe doesn't make sense, because there is just so much we don't know. If we wait until we do know, we'll be long gone by then.
Posted by Phil on October 14, 2012, at 11:06:51
In reply to Re: Hope for the future? » Phil, posted by phillipa on October 13, 2012, at 23:57:21
As long as I get wrapped in butcher paper I'm ready. :)
Posted by phillipa on October 14, 2012, at 19:34:33
In reply to Re: Hope for the future? » phillipa, posted by Phil on October 14, 2012, at 11:06:51
Ha ha who knows right? Phillipa
Posted by ChicagoKat on October 15, 2012, at 19:04:59
In reply to Re: Hope for the future? » ChicagoKat, posted by Phil on October 13, 2012, at 17:08:01
> I've always really wished I could travel through time. I would love, and be freaked out, to see what is happening in 200 years. I've spent hours thinking about it.
> Would anything be recognizable? What would we dress like? Would we be speaking Chinese :), would the planet be here? What would the population be? Would we be paying tons of money for water if there was any? I guess we would be dead in that case.
>
> If anyone has ideas I'd love to hear them.I think about exactly the same things Phil! I find it fascinating as well, b/c I think of the opposite alternative too: what if a person from 200yrs ago could travel to our time? Imagine their reaction to cars, let alone planes!! I bet we can't even truly guess at what we'd see 200yrs from now....the only idea I can think of with any real plausibility is that we'll have killed most of the population as well as most of the plants and animals by setting off nuclear bombs against each other. :(
Kat
Posted by ChicagoKat on October 15, 2012, at 19:06:30
In reply to Re: Hope for the future? » Phil, posted by phillipa on October 13, 2012, at 23:57:21
> Phil remember when people talked of freezing their bodies and coming back when a solution to what they were deceased from had been found? We could build a big freezer and wait there. Phillipa
I would love to be frozen until a really good cure for depression/anxiety was found...sign me up!!
Kat
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