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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 57 to 81 of 81. Go back in thread:
Posted by linkadge on September 15, 2012, at 5:59:12
In reply to Re: is a GABA antagonist what i need?, posted by phidippus on September 11, 2012, at 17:49:44
The beta carbolines were recognized to be benzodiazapine antagonists quite some time ago. They were used to test gaba's mechanisms in anxiety and panic. It was recognized that they could produce extreme anxiety in test subjects and that this could be reversed by benzodiazapines.
If you want low doses of a gaba antagonist why not just drink coffee or eat chocolate (a natural source of beta carbolines)?
Posted by linkadge on September 15, 2012, at 6:01:48
In reply to Re: is a GABA antagonist what i need?, posted by poser938 on September 11, 2012, at 18:33:56
>my doc prescribed Gabapentin today and she said to >only get a 3 day fill of this. if it doesnt work >we will be trying a GABA antagonist. she said it >makes a lot of sense to try this next.
Yeah, sure it makes a lot of sense.
If driving north on road A doesn't get you to your destination, **surely** driving south on the same road will.
Linkadge
Posted by linkadge on September 15, 2012, at 6:02:22
In reply to Re: is a GABA antagonist what i need?, posted by poser938 on September 11, 2012, at 18:51:21
I think you're making this up. No doctor would be that foolish.
Linkadge
Posted by linkadge on September 15, 2012, at 6:15:04
In reply to Re: is a GABA antagonist what i need? » AlexCanada, posted by phidippus on September 12, 2012, at 17:13:11
Flooding the brain's pleasure centres with dopamine does about as much to fix depression as Ben Bernanke printing money (Quantitative Easing - QE3) fixes the economy.
Linkadge
Posted by linkadge on September 15, 2012, at 6:19:29
In reply to Re: is a GABA antagonist what i need?, posted by poser938 on September 12, 2012, at 19:58:21
So....let me see if I have this right. You were perfectly fine before using drugs. Then, for no apparent reason (in your perfectly mentally healthy state) you decide to take an antidepressant. Then, after permanently warping your brain you decide that taking *another* drug is the solution to the fact that you were perfectly fine without drugs to begin with.
Linkadge
Posted by linkadge on September 15, 2012, at 6:22:52
In reply to Re: is a GABA antagonist what i need?, posted by poser938 on September 12, 2012, at 19:58:21
You said that mirapex had the negative effect of making it difficult for you to experience pleasure.
So.........huh..........you're making no sense. If direct dopaminergic stimulation makes your anhedonia worse... why do you want to take a flumazenil based on the premise that it will work because it increases dopamine??
Linkadge
Posted by phidippus on September 15, 2012, at 15:21:04
In reply to Re: is a GABA antagonist what i need?, posted by linkadge on September 15, 2012, at 6:01:48
Hilarious.
You should leave the poor boy alone.
Eric
Posted by phidippus on September 15, 2012, at 15:23:05
In reply to Re: is a GABA antagonist what i need?, posted by linkadge on September 15, 2012, at 5:59:12
Thanks for the info. More coffee it is, then. Wait, I'm not the one that wants a GABA antagonist.
Eric
Posted by phidippus on September 15, 2012, at 15:24:27
In reply to Re: flumazenil is probably acutely neurotoxic, posted by linkadge on September 15, 2012, at 5:53:01
I love cocaine!
Eric
Posted by phidippus on September 15, 2012, at 16:16:01
In reply to Re: My diagnosis and what I take » AlexCanada, posted by SLS on September 14, 2012, at 23:26:32
>I intend to attempt to discontinue it.
I hope you don't become manic.
Eric
Posted by phidippus on September 15, 2012, at 16:40:03
In reply to My diagnosis and what I take » phidippus, posted by AlexCanada on September 14, 2012, at 23:02:03
>My doctor thinks I may have bi-polar even though >I've never been manic or exhibited any of the >symptoms.
Sometimes mania can present as a bunch of anxiety. Do you experience any cycling in your mood?
>I take Gapapentin for short term relief of many >symptoms
Take it all the time. You're not going to build up a tolerance to it-it doesn't work that way
>valium 2.5mg 4x a day
Benzodiazapines can compound depression.
>Zoloft 25mg
Seems like Paxil or Parnate were better than the Zoloft. Why don't you take either one or even both again?
> Severely poor long term memory and ability to retain new knowledge
Aricept can help with memory issues. So can Keppra.
>Antero Grade Memory Loss
You need therapy to learn to live with this.
> Lack of emotions, Anhedonia, Dysphoria, Mind feeling blocked/cloudy, Severe lack of enjoyment, Lack of drive/motivation/desire/sense of reward, Difficulty relating to others and feel bit like a zombie, Severe difficulty being social (also partially due to inability to relate),
Depresssion sucks.
>Ritalin/Dex
Some of your cognitive issues may be ADHD related. I'd recommend you get back on a stim.
I wonder if some of your symptoms may be somatic. How have you fared in therapy?
Eric
Posted by SLS on September 15, 2012, at 16:51:48
In reply to Re: My diagnosis and what I take » SLS, posted by phidippus on September 15, 2012, at 16:16:01
Regarding Abilify:
> > I intend to attempt to discontinue it.
> I hope you don't become manic.
Yes. This is a concern of mine.
- Scott
Posted by phidippus on September 15, 2012, at 17:44:51
In reply to Re: My diagnosis and what I take » phidippus, posted by SLS on September 15, 2012, at 16:51:48
Increase your Lithium to 1200 mg and you won't have to worry. ;)
Do you think Abilify's 5ht1a partial agonism is affecting your mood in any way?
Eric
Posted by poser938 on September 15, 2012, at 21:51:27
In reply to Re: is a GABA antagonist what i need?, posted by linkadge on September 15, 2012, at 6:22:52
Linkadge, if you see me post on this board again... i dont need your 2 cents. have a nice day.
Posted by poser938 on September 15, 2012, at 22:13:07
In reply to Re: is a GABA antagonist what i need?, posted by linkadge on September 15, 2012, at 6:22:52
i had actually brought your idea to her at my appointment. about how my idea is strange. she said not to listen to you because she said that we are smarter than you.
Posted by AlexCanada on September 16, 2012, at 15:25:28
In reply to Re: My diagnosis and what I take » AlexCanada, posted by phidippus on September 15, 2012, at 16:40:03
> >My doctor thinks I may have bi-polar even though >I've never been manic or exhibited any of the >symptoms.
>
> Sometimes mania can present as a bunch of anxiety. Do you experience any cycling in your mood?No. My mood tends to be consistently low, dull, low energy, poor cognition, poor interest, poor drive, poor motivation, poor ability to enjoy anything, some bit of on and off anxiety (usually depending if I take certain supplements/herbals etc). sometimes in the morning or late at night i may feel slightly better but there is no cycling.
> >I take Gapapentin for short term relief of many >symptoms
>
> Take it all the time. You're not going to build up a tolerance to it-it doesn't work that wayIt has the most potent effect for me when I start it up. Even 100mg can have a very positive effect but as the days progress 100mg ends up doing very little, then it's about 200mg making a positive difference, then 300mg and so forth. Then eventually side effects at 600mg a day become very annoying and much of the benefits don't present themselves anymore. I used to be able to take gabapentin 300mg twice a day about 3 years ago and it would continue to work well for me despite still limited interest. For some reason it eventually would not work as well beyond a certain point. Before it developed less tolerance. These days it develops tolerance quite quickly. I am also noticing the longer I stay on this Zoloft junk the less effective gabapentin is when I try it once in a while for some relief. Yet very little relief arrives.
If there is some trick for helping gabapentin prevent tolerance it would be very helpful.
> >valium 2.5mg 4x a day
>
> Benzodiazapines can compound depression.I'd love to not take valium if my overall mood would benefit but each time I've tried to stop valium I'd have some temporary benefit including cognition but eventually there would be very protracted withdrawal and possibly a mix of pre-benzo symptoms. I would feel very dark and dysphoric and intense anxiety would manifest itself. My cognition would be even worse as well. This would persist for weeks until i could not take it anymore and end up taking valium again and find it relieve those horrific symptoms. How much of it is withdrawal and how much of it is my most severe depressed state I am not sure but it is clear that withdrawal is a significant part of it due to how quickly valium can help if I didn't take it for a while. How horrific i felt without valium would be a bit of flashback to how painful being alive would feel when my strong melancholic depression + anxiety began when I was 18.
> >Zoloft 25mg
>
> Seems like Paxil or Parnate were better than the Zoloft. Why don't you take either one or even both again?Paxil was very beneficial for years but it wore off. I tried to start it again this year but it just made me feel dull, dumb, impaired, I couldn't stand it. Parnate worked well for about a year and a half. Beyond that it lost much of it's benefit. I end up feeling constantly tired when I was back on it for a few months this summer and it was one of the worst summers I have had in years.
I am day 10 on zoloft now. I been considering stopping it but am trying to give this mind numbing apathy inducing junk a fair shot. Paxil 10mg was the magic number for me. Even 9.5mg paxil to be more precise. What might be the equivilent dose for Zoloft?
> > Severely poor long term memory and ability to retain new knowledge
>
> Aricept can help with memory issues. So can Keppra.Thanks. I may have those in my list but I'll look into them again. Here in Canada it has become more difficult to order medications due to government regulations but I'll see what I can do.
> >Antero Grade Memory Loss
>
> You need therapy to learn to live with this.
>
> > Lack of emotions, Anhedonia, Dysphoria, Mind feeling blocked/cloudy, Severe lack of enjoyment, Lack of drive/motivation/desire/sense of reward, Difficulty relating to others and feel bit like a zombie, Severe difficulty being social (also partially due to inability to relate),
>
> Depresssion sucks.
>
> >Ritalin/Dex
>
> Some of your cognitive issues may be ADHD related. I'd recommend you get back on a stim.
>
> I wonder if some of your symptoms may be somatic. How have you fared in therapy?
>
> Eric
>
>Therapy has been worthless for me. It is more frustrating than anything when some of those therapists feel people like me should just ''snap'' out of it. Most of them just don't get it.
Posted by linkadge on September 17, 2012, at 7:29:10
In reply to Re: is a GABA antagonist what i need?, posted by poser938 on September 15, 2012, at 22:13:07
>i had actually brought your idea to her at my >appointment. about how my idea is strange. she >said not to listen to you because she said that we >are smarter than you.
the two of you combined - or individually?
Linkadge
Posted by phidippus on September 17, 2012, at 15:38:49
In reply to Re: is a GABA antagonist what i need?, posted by linkadge on September 17, 2012, at 7:29:10
>>said not to listen to you because she said that we are smarter than you.
>the two of you combined - or individually?
Good one! *slap on the knee* Haha!
Eric
Posted by phidippus on September 17, 2012, at 18:17:19
In reply to Re: My diagnosis and what I take » phidippus, posted by AlexCanada on September 16, 2012, at 15:25:28
>No. My mood tends to be consistently low
Have you tried using two antidepressants together, such as Paxil + Wellbutrin?
>If there is some trick for helping gabapentin prevent tolerance it would be very helpful.
You really shouldn't be building up a tolerance.
>therapists feel people like me should just ''snap'' out of it.
My therapist doesn't treat me that way. A good therapist could be an invaluable assett.
Eric
Posted by poser938 on September 17, 2012, at 21:21:00
In reply to Re: is a GABA antagonist what i need?, posted by linkadge on September 17, 2012, at 7:29:10
Linkadge, what is your favorite thing about arguing with someone you have never met on the internet?
Posted by poser938 on September 17, 2012, at 21:29:12
In reply to Re: is a GABA antagonist what i need?, posted by linkadge on September 17, 2012, at 7:29:10
you can write back or not write back. it doesnt matter. i was just having a bad night a few nights ago when you called my idea strange, i won't be replying to anything else you or your comrade writes to me. i pinky promise.
Posted by poser938 on September 17, 2012, at 21:34:22
In reply to Re: is a GABA antagonist what i need?, posted by linkadge on September 17, 2012, at 7:29:10
HURRAY EVERYONE!!! Linkadge is the winner of this super awesome internet argument! lol anyway just have a good one, alright?
Posted by phidippus on September 17, 2012, at 22:30:28
In reply to Re: is a GABA antagonist what i need?, posted by poser938 on September 17, 2012, at 21:34:22
LOL
Posted by Gia36 on September 17, 2012, at 23:50:55
In reply to My diagnosis and what I take » phidippus, posted by AlexCanada on September 14, 2012, at 23:02:03
Wow, so much going on here.
You said it started at 18-I was thinking, after reading all this, google schitzotypy and read Wiki. I don't mean schitzophrenia, or anything psychosis related. See if you relate.You might have better luck trying antipsychotics. From what you wrote, the ones you tried gave you some benefits.
Not that its not from stimulants, but it might be worth a try to go towards drugs that target negative effects of schitzophrenia. Those symptoms are really hard to treat. Any relatives with schitzophrenia?Think about this-catatonia, an extreme vegetative like state, is treated with SEDATIVES. Maybe dopamine dysfunction produces the opposite effect-over stimulation-in your case. So even if its blah, could it be over stimulation??
The ritalin might have worked temporarily, just like cocaibe produces a high in people with no mental condition.And schitzoypy is not a diagnosis, just thinking out of the box. Hope you find relief sooner than later.
Posted by SLS on September 17, 2012, at 23:56:15
In reply to Re: My diagnosis and what I take » AlexCanada, posted by Gia36 on September 17, 2012, at 23:50:55
> Wow, so much going on here.
> You said it started at 18-I was thinking, after reading all this, google schitzotypy and read Wiki. I don't mean schitzophrenia, or anything psychosis related. See if you relate.
>
> You might have better luck trying antipsychotics.That's an interesting idea.
> From what you wrote, the ones you tried gave you some benefits.
> Not that its not from stimulants, but it might be worth a try to go towards drugs that target negative effects of schitzophrenia. Those symptoms are really hard to treat. Any relatives with schitzophrenia?
>
> Think about this-catatonia, an extreme vegetative like state, is treated with SEDATIVES. Maybe dopamine dysfunction produces the opposite effect-over stimulation-in your case. So even if its blah, could it be over stimulation??That's another interesting idea.
I think both ideas have merit.
- Scott
This is the end of the thread.
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