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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Chairman_MAO on October 18, 2011, at 20:57:55
I'm at 30mg/day and it is giving me absolutely _horrible_, unremitting gas. Has anyone else experienced this? I do hope this goes away or is responsive to some sort of medication, because this is not good, and I'm probably going to need at least 60mg/day of this stuff for it to work.
What good is taking something for social phobia if no one would ever want to be around me? ;-)
Anyone had this experience?
Posted by Phillipa on October 18, 2011, at 21:21:42
In reply to Unexpected, untoward Marplan side effect ..., posted by Chairman_MAO on October 18, 2011, at 20:57:55
I'm sorry but would something for gas work? Beano? You kind of made me laugh not being mean. Phillipa
Posted by Chairman_MAO on October 18, 2011, at 21:35:54
In reply to Re: Unexpected, untoward Marplan side effect ... » Chairman_MAO, posted by Phillipa on October 18, 2011, at 21:21:42
> I'm sorry but would something for gas work? Beano? You kind of made me laugh not being mean. Phillipa
Yeah, it's absurd, but trust me, it's _very_ real. ;-)
I am not sure what would be the most appropriate thing to use. That is why I posted.
Posted by jono_in_adelaide on October 18, 2011, at 22:15:23
In reply to Re: Unexpected, untoward Marplan side effect ... » Phillipa, posted by Chairman_MAO on October 18, 2011, at 21:35:54
Just guessing, but I'd try simethicone first (Phazyme or the generic pharmacy brand)
How is it going otherwise?
Posted by Chairman_MAO on October 18, 2011, at 23:41:03
In reply to Re: Unexpected, untoward Marplan side effect ..., posted by jono_in_adelaide on October 18, 2011, at 22:15:23
> Just guessing, but I'd try simethicone first (Phazyme or the generic pharmacy brand)
>
Yeah, I figured I'd give that a try.> How is it going otherwise?
Haven't noticed much yet, but It's still the first week. Feel a little better, but I haven't even hit 40mg yet. I'm not sure that 40mg is even going to do it, so I'm awaiting next visit to go to 60. ;-) But maybe it will, time will tell ...
Thanks for your concern.
Posted by sigismund on October 19, 2011, at 2:56:11
In reply to Unexpected, untoward Marplan side effect ..., posted by Chairman_MAO on October 18, 2011, at 20:57:55
Does it mean your gut is unhappy?
That is what a doctor said to me once about it.
Would probiotics help? Or certain kinds of food?
Posted by SLS on October 19, 2011, at 5:57:56
In reply to Re: Unexpected, untoward Marplan side effect ... » Chairman_MAO, posted by sigismund on October 19, 2011, at 2:56:11
You may need to limit your dairy intake. I had that problem with Nardil, and it seemed to get worse when I would ingest milk. Flatulence is listed as a side effect of Nardil. I don't know about Marplan.
I hope it resolves of its own accord.
- Scott
Posted by Chairman_MAO on October 19, 2011, at 7:57:20
In reply to Re: Unexpected, untoward Marplan side effect ..., posted by SLS on October 19, 2011, at 5:57:56
I'm not sure if that's the solution, given that my dairy intake is not particularly great. How severely did you have to limit it? Did it go away or get any better with time?
I never had that problem with Nardil--the differences between people are fascinating.
Thanks for your support.
> You may need to limit your dairy intake. I had that problem with Nardil, and it seemed to get worse when I would ingest milk. Flatulence is listed as a side effect of Nardil. I don't know about Marplan.
>
> I hope it resolves of its own accord.
>
>
> - Scott
Posted by SLS on October 19, 2011, at 8:40:37
In reply to Re: Unexpected, untoward Marplan side effect ... » SLS, posted by Chairman_MAO on October 19, 2011, at 7:57:20
> I'm not sure if that's the solution, given that my dairy intake is not particularly great.
You are probably right, then.
> How severely did you have to limit it?
Only moderately. I still used milk on cereal.
> Did it go away or get any better with time?
No, it really never resolved over time.
I remember having quite a bit more trouble during my time taking a combination of Parnate with desipramine. It seemed to get worse as my depression improved, and was not associated with dairy intake.
One thing to consider is that GI motility is often decreased as a symptom of depression, leading to constipation. I think gas might be a function of increased motility that might be associated with a favorable response to treatment. I hope that your gas is an indicator of a response to Marplan.
Would increasing fiber intake make flatulence better or worse? I really don't know.
I received some therapeutic benefit from Marplan, but not enough to remain on it. Were I in your position, I would continue with Marplan for a few weeks once you arrive at the higher dosage. There are some people whom respond better to Marplan than to Nardil. A great many of these people had to apply for a compassionate use protocol during the time that Marplan was taken off the market.
- Scott
Posted by jono_in_adelaide on October 19, 2011, at 20:02:40
In reply to Re: Unexpected, untoward Marplan side effect ... » Chairman_MAO, posted by SLS on October 19, 2011, at 8:40:37
"Would increasing fiber intake make flatulence better or worse? I really don't know"
Depends wether the fibre is fermentable (eg beans, oat bran, Metamucil) or non fermentable (cellulose, wheat bran, Cellulone)
Fermentable fibre makes you f*rt, non fermentable doesnt. Might be worth trying a daily glass of Cellulone, see if that helps at all. Simethicone capsules might also help (eg Phazyme)
Posted by Chairman_MAO on October 21, 2011, at 18:28:39
In reply to Re: Unexpected, untoward Marplan side effect ... » Chairman_MAO, posted by SLS on October 19, 2011, at 8:40:37
Thanks for the tips. It actually seems to be getting better with time--and a higher dose (now at 40mg). I don't think this is going to cut it, though; I want to go to 60 at the next visit. If he lets me stay on a little clonazepam, it may be enough. I'm not sure. It's still too early to tell what the effect of 40 is going to be, but I've been down this road so many times I think I know. It seems like 45, maybe 60mg of phenelzine--but it's hard to tell because of clonazepam.
Keeping my fingers crossed. It's really annoying not being able to take Dexedrine, but I think it'
ll be worth the wait. As I said before, getting up to 60mg/day the first time around took over a year (while on Nardil). I think he plans to do it faster, but really I don't have all the time in the world; perhaps he'll let me see him every two weeks. But I don't want to put the cart before the horse.Cheers.
This is the end of the thread.
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