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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 17 of 17. This is the beginning of the thread.
Posted by ShawnThomas on June 15, 2011, at 23:11:29
http://www.neurotransmitter.net/newdrugs.html has finally been updated :)
JR Becker helped me with the last in the past, but I haven't been able to reach him for a couple years. As a result, I had to take some time to figure out the best method to keep the list current. I plan update the list 3 to 4 times per year. I welcome any corrections...
Shawn
Posted by zonked on June 16, 2011, at 0:42:16
In reply to List of Drugs in US Phase II/III clinical trials, posted by ShawnThomas on June 15, 2011, at 23:11:29
Do you know if Pfizer plans to pursue an indication for pregabalin for GAD in the US?
It's a shame if not - such a good drug for anxiety...
-z
Posted by Phillipa on June 16, 2011, at 11:00:18
In reply to List of Drugs in US Phase II/III clinical trials, posted by ShawnThomas on June 15, 2011, at 23:11:29
Shawn I thought the two of you worked together. Great to see you here. Phillipa
Posted by ShawnThomas on June 16, 2011, at 12:50:06
In reply to Re: List of Drugs in US Phase II/III clinical trials » ShawnThomas, posted by zonked on June 16, 2011, at 0:42:16
> Do you know if Pfizer plans to pursue an indication for pregabalin for GAD in the US?
>
> It's a shame if not - such a good drug for anxiety...
>
> -zPfizer announced in March that they will no longer be conducting trials for pregabalin as a treatment for Generalized Anxiety Disorder (http://centerwatch.com/news-online/headline-details.aspx?HeadlineID=1093). Sorry.
Posted by ShawnThomas on June 16, 2011, at 12:53:56
In reply to Re: List of Drugs in US Phase II/III clinical trials » ShawnThomas, posted by Phillipa on June 16, 2011, at 11:00:18
> Shawn I thought the two of you worked together. Great to see you here. Phillipa
Thanks. In the past, JR would create the basic list in Word, and I would edit the list when necessary. I am not sure what happened to JR and hope that he is doing OK. I think he may have just become bored with creating the list; hopefully that's all that happened. An upside of the new arrangement is that there are now links to almost every company's pipeline, and you can use those links if you want to see if a drug has advanced since the list was last updated.
Posted by europerep on June 16, 2011, at 13:11:38
In reply to List of Drugs in US Phase II/III clinical trials, posted by ShawnThomas on June 15, 2011, at 23:11:29
> I welcome any corrections...
Hi there.RO4917523 is in Phase II trials in the United States:
http://www.clinicaltrials.gov/ct2/show/NCT00809562This used to be listed on your website as "RO 4917523/EVT 101", but the two are different molecules.
Bye,
ER
Posted by ShawnThomas on June 16, 2011, at 13:59:32
In reply to Re: List of Drugs in US Phase II/III clinical trials » ShawnThomas, posted by europerep on June 16, 2011, at 13:11:38
Thanks. I am confused by that link. Roche doesn't list a drug by that name in their pipeline, but they do have a drug called RG7090 that's in Phase II for treatment resistant depression and shares the same mechanism of action.
I am trying to make the list closely reflect pharmaceutical company's pipelines, so that drug will have to go on my list of drugs to watch. Drug companies like to pare their pipelines down sometimes, especially following mergers, so my guess is that they found RG7090 to be the better option of the pair. If I focus solely on what's ClinicalTrials.gov, that seems to lead to a lot of drugs that aren't currently in industry pipelines.
> > I welcome any corrections...
>
> Hi there.
>
> RO4917523 is in Phase II trials in the United States:
> http://www.clinicaltrials.gov/ct2/show/NCT00809562
>
> This used to be listed on your website as "RO 4917523/EVT 101", but the two are different molecules.
>
> Bye,
> ER
>
>
>
Posted by europerep on June 16, 2011, at 15:38:48
In reply to Re: List of Drugs in US Phase II/III clinical trials, posted by ShawnThomas on June 16, 2011, at 13:59:32
Yeah, I saw there was a different mGluR5 antagonist from Roche, but the link to clinicaltrials.gov didn't show any results for that, so I thought they may have renamed it or something. Also I'm not sure whether the RG prefix would indicate a cooperation with some company, instead of a "pure" Roche development beginning with RO.
Anyhow, thanks for keeping an eye on all these new developments, it's much appreciated!
P.S.: You only feature *new* drugs, right? If not, you could add ketamine to the list?
> Thanks. I am confused by that link. Roche doesn't list a drug by that name in their pipeline, but they do have a drug called RG7090 that's in Phase II for treatment resistant depression and shares the same mechanism of action.
>
> I am trying to make the list closely reflect pharmaceutical company's pipelines, so that drug will have to go on my list of drugs to watch. Drug companies like to pare their pipelines down sometimes, especially following mergers, so my guess is that they found RG7090 to be the better option of the pair. If I focus solely on what's ClinicalTrials.gov, that seems to lead to a lot of drugs that aren't currently in industry pipelines.
>
Posted by zonked on June 16, 2011, at 16:36:39
In reply to Re: List of Drugs in US Phase II/III clinical trials, posted by ShawnThomas on June 16, 2011, at 12:50:06
> Pfizer announced in March that they will no longer be conducting trials for pregabalin as a treatment for Generalized Anxiety Disorder (http://centerwatch.com/news-online/headline-details.aspx?HeadlineID=1093). Sorry.
Ah, that's too bad. The limited experience I had with this drug was rather awesome in terms of anxiolytic effect. I should have no problem getting it prescribed if I become interested in it, but it's too bad. The indication would probably lead to greater MD adoption in the US for a substance the FDA considers less abusable than benzos (Schedule V), and at least in my experience, far more effective than something like BuSpar.
-z
Posted by ShawnThomas on June 16, 2011, at 19:13:20
In reply to Re: List of Drugs in US Phase II/III clinical trials, posted by europerep on June 16, 2011, at 15:38:48
> P.S.: You only feature *new* drugs, right? If >not, you could add ketamine to the list?
Yes, I would like to keep the list as manageable as possible. I decided to focus on drugs that have not been previously approved by the FDA. I also removed the Phase I drugs because they've often seemed to me like a bit of a distraction from the drugs that are more likely to eventually make it to market in the US. There will no longer be mentions of European clinical trials; that sort of thing requires JR's approach of reading large numbers of news articles rather than my more pipeline-focused method.
Posted by Phillipa on June 16, 2011, at 22:01:46
In reply to Re: List of Drugs in US Phase II/III clinical trials, posted by ShawnThomas on June 16, 2011, at 19:13:20
Shawn I'm sure you have JR's email. I might also have one. Why not introduce yourself to all these new babblers by telling them a bit about yourself. Still on Google? Phillipa
Posted by jhj on June 17, 2011, at 0:22:14
In reply to List of Drugs in US Phase II/III clinical trials, posted by ShawnThomas on June 15, 2011, at 23:11:29
Hi,Thanks for the updated list. I am just curious about couple of things in your list.
1. I read that SSR 125543 has been discontinued by sanofi in phase II2. Your list does not mention GLYX-13 a drug in phase II being developed by Naurex.
http://clinicaltrials.gov/ct2/show/NCT01234558?intr=%22GLYX-13%22&rank=2
Thanks
jhj
Posted by ShawnThomas on June 17, 2011, at 15:17:52
In reply to Re: List of Drugs in US Phase II/III clinical trials, posted by jhj on June 17, 2011, at 0:22:14
> Hi,
>
> Thanks for the updated list. I am just curious about couple of things in your list.
> Thanks
> jhjYou're welcome. Thanks for your help; I've updated the list based on your suggestions.
Shawn
Posted by ShawnThomas on June 17, 2011, at 15:18:45
In reply to Re: List of Drugs in US Phase II/III clinical trials, posted by jhj on June 17, 2011, at 0:22:14
> Hi,
>
> Thanks for the updated list. I am just curious about couple of things in your list.
> Thanks
> jhjYou're welcome. Thanks for your help; I've updated the list based on your suggestions.
Shawn
Posted by ShawnThomas on June 17, 2011, at 16:08:05
In reply to Re: List of Drugs in US Phase II/III clinical trials » ShawnThomas, posted by Phillipa on June 16, 2011, at 22:01:46
> Shawn I'm sure you have JR's email. I might also have one. Why not introduce yourself to all these new babblers by telling them a bit about yourself. Still on Google? Phillipa
Yes, I have his e-mail. I am not sure what you mean by "Still on Google," but the company is a friend of mine in many ways. I'm guessing that you are interested in my academic history...
I have a Master of Science degree in Library and Information Science from the school that US News & World Report has consistently ranked as the best LIS graduate school, GSLiS at the University of Illinois at Urbana-Champaign. I learned a lot from Associate Dean Dr. Linda Smith about the medical aspect of library & information science. My accomplishments included selection to the Chancellor's List and a 3.96 GPA.
I also have a Bachelor of Science degree in Biopsychology from Quincy University, where I was on the Dean's List every semester and was selected to the National Dean's List. I spent the first half of my college career studying computer science at the University of Illinois at Chicago, where I was selected to the Golden Key International Honour Society. I have two years of professional library experience, some of it related to medical reference, and over ten years of web development experience. I've collaborated in the past with researchers at universities around the world, with biomedical companies, and with researchers associated with the pharmaceutical industry. I've discussed the future of neuroscience research with drug company executives in the past but have no preference for any particular companies.
I've written summaries of drugs' mechanisms of action based on my own extensive research; my areas of expertise are psychiatric drugs, general anesthetics, Parkinson's disease drugs, drugs of abuse, migraine, drugs for muscle spasms, and Alzheimer's disease drugs. I've read multiple textbooks about pharmacology, with perspectives ranging from nursing to anesthesiology to the most advanced texts available such as Goodman and Gilman's.
I have a wide range of scientific interests that include neuropharmacology, physics, cosmology, psychology, herbal medicine, philosophy of science, etc. My scientific heros are William T. Powers, Ted Steele, Milo Wolff, Eric J Lerner, and Albert Einstein. I don't believe in the big bang, Creationism, the Standard Model of Particle Physics, dark energy, dark matter, behaviorism, or the idea that all life has evolved solely by random mutation and natural selection.
My view is that publishing in journals, writing books, or using social networking websites is no longer necessary to reach millions of people with one's scientific ideas. I am against censorship in any form, whether it be dictated by an authoritarian ruler or a tradition bound scientific community. I believe that scientific ideas should be evaluated based on evidence and sound logic rather than popularity and blind media acceptance. Information itself cannot want to be free, so the well-informed are responsible for helping it along in my opinion.
Posted by Phillipa on June 17, 2011, at 20:21:50
In reply to Re: List of Drugs in US Phase II/III clinical trials » Phillipa, posted by ShawnThomas on June 17, 2011, at 16:08:05
Shawn exactly what I meant that's so kind of you. Meant once googled you name and many hits. Phillipa
Posted by jhj on June 18, 2011, at 0:00:56
In reply to Re: List of Drugs in US Phase II/III clinical trials » jhj, posted by ShawnThomas on June 17, 2011, at 15:18:45
Hi,there is one more drug being developed by Euthymics Bioscience is in Phase IIb/IIIa for Major Depressive Disorder
jhj
This is the end of the thread.
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