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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by roscopeeco on December 27, 2010, at 9:56:17
I have yet to determine the differences between the two. I know one promotes antagonism and the other agonism, but both increase dopamine. I need help in figuring this out. Supposedly Amisulpride increases dopamine activity at low doses and the reverse at higher does. Mirapex does not show this dose specific variation. How does one go about choosing which would be a better augmenting agent?
Posted by Phillipa on December 27, 2010, at 12:36:38
In reply to Amisulpride vs Mirapex, posted by roscopeeco on December 27, 2010, at 9:56:17
I don't know but would like to know. Phillipa
Posted by europerep on December 27, 2010, at 14:06:41
In reply to Amisulpride vs Mirapex, posted by roscopeeco on December 27, 2010, at 9:56:17
>How does one go about choosing which would be a better augmenting agent?
why do you think about augmenting less than three weeks into your parnate trial? as hard as it may be - and I *know* it is hard - I think you really need to have some patience before thinking about augmenting..
either way, I haven't personally heard of augmenting parnate (tranylcypromine) with either amisulpride or pramipexole.. the "usual" options would be amitriptyline, nortriptyline, mirtazapine, or stimulants like methylphenidate.. all that is *relatively* dangerous territory though, and it must be under medical supervision and adhering to how the doctor prescribes!sorry, it's not to sound like an ass, but you sound like quite a risk-taker ;)..
Posted by roscopeeco on December 28, 2010, at 5:23:59
In reply to Re: Amisulpride vs Mirapex, posted by europerep on December 27, 2010, at 14:06:41
I am not actually thinking about augmenting it right this moment. I am just having some sort of backup plan in tact. You are right. I am an extreme risk taker when it comes to getting out of this depression.
It is awful. I sit here everyday thinking when will it all be over. When will I be able to actually want to get out of the house. When will I be excited about seeing friends. My depression is not as bad as it was 2.5 months ago where I was sitting behind a dumpster with a gun to my head, but it is present none the less. That was my first real bottom where I said screw it. I don't want to live anymore. It hurts to see my family on pins and needles all the time. I am supposed to start post graduate school on Jan. 6th and I don't even know if i have the energy or the drive to start. These things are so frustrating to me. I am just venting and desperate to feel alive again.
I know 2 weeks and 5 days isn't enough time on parnate. Was your depression extremely bad Europa?
Posted by bleauberry on December 28, 2010, at 5:24:24
In reply to Amisulpride vs Mirapex, posted by roscopeeco on December 27, 2010, at 9:56:17
Amisulpride has the better track record, clinically and anecdotally.
The side effects of Mirapex are pretty rough and most people who have tried it had a hard time with it.
Posted by roscopeeco on December 28, 2010, at 5:54:10
In reply to Re: Amisulpride vs Mirapex, posted by bleauberry on December 28, 2010, at 5:24:24
> Amisulpride has the better track record, clinically and anecdotally.
>
> The side effects of Mirapex are pretty rough and most people who have tried it had a hard time with it.This is a good study of why Amisulpride is effective.
http://www.springerlink.com/content/515j16481x05557v//fulltext.html#Fig1
This is the end of the thread.
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