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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by europerep on June 12, 2010, at 14:57:40
hey there..
I thought I was just gonna let you know that a new drug is about to enter phase II trials soon. and by "new" I really mean new, not another form of 5HT reuptake or something, it's an actual NMDAr antagonist, resulting from a collaboration between EvoTec Germany and Roche Switzerland. seriously, what could be a higher quality product than german (bio)engineering combined with swiss craftsmanship and precision? ;-)
here is an info from the evotec site:
http://www.evotec.com/article/en/Pipeline/Clinical/EVT-101-103/11/4/6also, I was wondering whether there might be information on clinical trials online, and voilą:
http://clinicaltrials.gov/ct2/show/NCT01128452too bad that the first clinical trials of a european invention are entering trials in the US only..no but seriously, they have 9 testing sites all across the US, so if one of you is really interested, print it out and show it to your doc, apparently they'll start enrolling patients in the second half of 2010.. I guess the difficult thing is that they seek patients with no more than three failed treatment regimes, and some here are well above that. anyway, I don't even know whether anyone of you would consider doing phase II trials, it's quite risky after all, but I was just gonna let you know..
the agent also goes under a name beginning with RO for roche, don't find the exact number right now, there are also trials listed under that name..
Posted by europerep on June 16, 2010, at 12:41:34
In reply to new drug for TR depression:EVT101, phase II, posted by europerep on June 12, 2010, at 14:57:40
seriously, did I sleep on something? I thought people were so impatiently waiting for NMDA antagonists that they considered trying low doses of ketamine or even PCP.. and wasn't there someone just a week ago or so who wanted to emulate NMDA antagonism by mixing certain substances, including zinc or something?
I would so much like to try out this new drug..
Posted by jade k on June 23, 2010, at 15:08:22
In reply to noone wants nmda antagonists anymore?, posted by europerep on June 16, 2010, at 12:41:34
> seriously, did I sleep on something? I thought people were so impatiently waiting for NMDA antagonists that they considered trying low doses of ketamine or even PCP.. and wasn't there someone just a week ago or so who wanted to emulate NMDA antagonism by mixing certain substances, including zinc or something?
>
> I would so much like to try out this new drug..
I haven't been around, what is it? (in simple terms)~jade
Posted by shasling on June 28, 2010, at 4:19:25
In reply to Re: noone wants nmda antagonists anymore? » europerep, posted by jade k on June 23, 2010, at 15:08:22
Google Minocycline and nmda antagonist. This is an acne antibiotic which just HAPPENS to have fairly significant NMDA antagonist properties. Isn't that great? Augment with magnesium...
Posted by europerep on July 17, 2010, at 10:36:09
In reply to Re: noone wants nmda antagonists anymore? » europerep, posted by jade k on June 23, 2010, at 15:08:22
hey there,
just a small update, it seems the phase II trials have started at the beginning of this month:
http://behavioralhealthcentral.com/index.php/20100701228686/Pharma-News/evotec-starts-phase-ii-clinical-studies-in-treatment-resistant-depression.htmljade, I didn't see any answer to this thread before it disappeared, that's why I didn't reply..
it's basically just another antidepressant, but it's made specifically for treatment-resistant depression. that doesn't mean it can't be used for regular depression, but I find it "courageous" to market it as that, because this obviously means that it has to outperform regular antidepressants already in the clinical trials.
I am very very interested in the development of these drugs, since NMDA antagonists like ketamine do show significant efficacy in TRD patients.
This is the end of the thread.
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