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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Netch on April 6, 2010, at 8:17:29
Coffee, tea and caffeine intake and the risk of severe depression in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study.
OBJECTIVE: Only a few cross-sectional studies have assessed the association between coffee, tea and caffeine and the risk of depression. Our aim was to determine the association in a population-based cohort study. DESIGN: The population-based Kuopio Ischaemic Heart Disease Risk Factor Study cohort was recruited between 1984 and 1989 and followed until the end of 2006. We investigated the association between the intake of coffee, tea and caffeine and depression. SETTING: Eastern Finland. SUBJECTS: Middle-aged men (n 2232). RESULTS: Altogether, forty-nine men received a discharge diagnosis of depression. We classified subjects into quartiles according to their mean daily coffee intake: non-drinkers (n 82), light drinkers (<375 ml/d, n 517), moderate drinkers (375-813 ml/d, n 1243) and heavy drinkers (>813 ml/d, n 390). Heavy drinkers had a decreased risk (RR = 0.28, 95 % CI 0.08, 0.98) for depression when compared with non-drinkers, after adjustment for age and examination years. Further adjustment for socio-economic status, alcohol consumption, smoking, maximal oxygen uptake, BMI and the energy-adjusted daily intakes of folate and PUFA did not attenuate this association (relative risk (RR) = 0.23, 95 % CI 0.06, 0.83). No associations were observed between depression and intake of tea (drinkers v. non-drinkers; RR = 1.19, 95 % CI 0.54, 2.23) or caffeine (highest quartile v. lowest quartile; RR = 0.99, 95 % CI 0.40, 2.45). CONCLUSIONS: Coffee consumption may decrease the risk of depression, whereas no association was found for tea and caffeine intake.
Posted by tensor on April 6, 2010, at 8:39:59
In reply to Coffee and depression, posted by Netch on April 6, 2010, at 8:17:29
> severe depression in middle-aged Finnish men
Hmm.. reminds me of someone.. ;)
Posted by Phillipa on April 6, 2010, at 10:49:32
In reply to Re: Coffee and depression, posted by tensor on April 6, 2010, at 8:39:59
My nursing newsletter had a similar article. Phillipa
Posted by ed_uk2010 on April 6, 2010, at 13:34:39
In reply to Re: Coffee and depression, posted by tensor on April 6, 2010, at 8:39:59
> > severe depression in middle-aged Finnish men
>
> Hmm.. reminds me of someone.. ;)Well you're not middle-aged yet. A family member?
Posted by linkadge on April 6, 2010, at 18:20:46
In reply to Re: Coffee and depression » tensor, posted by ed_uk2010 on April 6, 2010, at 13:34:39
Coffee (black and strong) seems to keep away many of the dark dark holes I often fall into. It does worsen anxiety a bit, but...
I think some spectulate that the flavanoids have some sort of protective effect. Alternatively, the beta carbolines in coffee (but not tea?) have somewhat potent MAO effects.
I would still argue that caffiene still has some effect on affective disorders. It has neuroprotective effects (which may help prevent) the neurotoxic effects of certain agents which may exascerbate depression. Furthermore it appears to inhibit trek-1 potassium channels. Trek-1 inhibitors like prozac and lamotrigine have antidepressant effects in animal models. Also there is the adenosine inhibiting effects. A2 and A4 receptor antagonists have antidepressant effects.
Tea (green and black) inhibits acetycholinsertase (and perhapse exert a depressogenic effect) on suceptable individuals. Perhaps this is why it is not associated with reduced depression.
This is the end of the thread.
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