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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by willey on January 15, 2010, at 18:59:48
Well just to be fair,and share,my newest 2 week now augment to my parnate cocktail has been a med called camprel.
Camprel has a very basic pharmocolgy,it modulates,you know balances the glutamate/gaba ratio.
Although its almost specificaly for alcohol with drawal,there are a very very few mentions of it in use for mood disorders and even ocd.However the lack of that type of info usualy would halt me on a med,the simply pharmocolgy of it,and how it is similiar to the idea behind curent mood stablizers made me choose to use it.
Effects were mild onset,follwed by a strong ability to push off depression,as well as a pro social effect.
Sounds good right? Well i noticed i was speaking holes in my signifcant others head,and i was altough less depressed,just looked at things with little importance,it just over all changed me.
But because of its effect on depression,which was robust,i suddenly felt as strong as the disease,i just had to lower the dose as i did not like who i was with the talking and other side effects.Last please dont confuse this with for say zonegran which inflicted a maniac affect on me,camprel had no body effect just yess idid feel too social and now im down to a much lower dose and it seems to be much better.
As with all meds,dose,what its used with,and how you are behaving always must be kept on close watched better if by a family member but this can keep u safer.
Posted by Phillipa on January 15, 2010, at 21:02:22
In reply to My newest parnate augment, posted by willey on January 15, 2010, at 18:59:48
So your're using the campral at a lower dose than when started? Is it good for anxiety? Phillipa
Posted by Sigismund on January 15, 2010, at 21:49:07
In reply to My newest parnate augment, posted by willey on January 15, 2010, at 18:59:48
Do you think it's like taurine?
Posted by willey on January 16, 2010, at 1:08:18
In reply to Re: My newest parnate augment » willey, posted by Phillipa on January 15, 2010, at 21:02:22
Ummm eh,if your anxiety was under control with a benzo perhaps,but its actualy and oddly stimulating,not like speed affect,just in a seperate way.
I cut the dose down cause of the potency of it to make u over excitied.
Posted by willey on January 16, 2010, at 1:11:14
In reply to Re: My newest parnate augment, posted by Sigismund on January 15, 2010, at 21:49:07
Taurine as u know stablizes electrical activity in the brain,as well as is a nmda ant agonist.
I think a few meds are based on taurines propeties.
Camprel how has a direct affect on gaba,something taurine does not,plus taurine being a supplement just isnt as potent as meds.
This med is unique,u feel calm yet u feel smart and talk a lot,its odd.
Taurine however is great for night time use.
Posted by bulldog2 on January 16, 2010, at 17:46:15
In reply to My newest parnate augment, posted by willey on January 15, 2010, at 18:59:48
> Well just to be fair,and share,my newest 2 week now augment to my parnate cocktail has been a med called camprel.
>
> Camprel has a very basic pharmocolgy,it modulates,you know balances the glutamate/gaba ratio.
>
>
> Although its almost specificaly for alcohol with drawal,there are a very very few mentions of it in use for mood disorders and even ocd.
>
> However the lack of that type of info usualy would halt me on a med,the simply pharmocolgy of it,and how it is similiar to the idea behind curent mood stablizers made me choose to use it.
>
>
>
> Effects were mild onset,follwed by a strong ability to push off depression,as well as a pro social effect.
>
> Sounds good right? Well i noticed i was speaking holes in my signifcant others head,and i was altough less depressed,just looked at things with little importance,it just over all changed me.
>
>
> But because of its effect on depression,which was robust,i suddenly felt as strong as the disease,i just had to lower the dose as i did not like who i was with the talking and other side effects.
>
> Last please dont confuse this with for say zonegran which inflicted a maniac affect on me,camprel had no body effect just yess idid feel too social and now im down to a much lower dose and it seems to be much better.
>
> As with all meds,dose,what its used with,and how you are behaving always must be kept on close watched better if by a family member but this can keep u safer.How do you think it mixes with the parnate? Does it change the parnate in any way. Is this drug anything like neurontin? When I mix neurontin and parnate each seems to work less.
Posted by willey on January 16, 2010, at 19:14:48
In reply to Re: My newest parnate augment, posted by bulldog2 on January 16, 2010, at 17:46:15
Yess i agree gabentin in even moderate doses change parnates effect.Camprel,and this is on its insert states,....camprel is not affected by any anti depressants,nor does camprel affect any other anti depressants,saying its action will feel the same regardless.
About your gabpentin which we both take,i recomend this,take the high dose at night,then create a cocktail of parnate in your daily dosing i.e you take say 60 mg,add a very very small pieace of nuerontion,perhaps a very small parnate friendly stim,i use caffiene,and if u had camprel for say that.
but try to take large doses of any med away from parnates dosing,and also try to see what a small cocktail does for parnate,without it,honestly parnate is dry,and horrid for me,thats just me,the small additions such as the very small gabentin,very small klonopin,half caffiene all create a single cocktail that seem to poteinate parnate,let me know how it goes.
Posted by inanimate peanut on January 16, 2010, at 21:27:20
In reply to My newest parnate augment, posted by willey on January 15, 2010, at 18:59:48
So it works primarily on GABA rather than dopamine, serotonin, or norepinephrine, right? I thought GABA was primarily anxiety more than depression-- am I wrong about that (I know it's not nearly that simple, but as a broad generalization)? So what do you think it's doing to work so well on your depression? Do you think it would work for depression in someone who had very little anxiety? I'm so glad you found something that working for you!!
Posted by willey on January 16, 2010, at 21:44:35
In reply to Re: My newest parnate augment, posted by inanimate peanut on January 16, 2010, at 21:27:20
Yess its very compicated,i just only learned a week ago about the inside receptors of dopamine,and only beacuse my girl has a issue where she had to learn about it.
And thats what u do,u just learn as much as u can.
Gaba isnt just gaba,it has sites,i.e gaba a,gaba b,and so on,Glutamte is actualy used as a mild anti deprassant or congnitive ehancer,at small doeses makes u sharp and alert.
When it dominates the brain and leaves u in a excitied constant alert stage,a fight or flight,this is what i believe,and im not sure is what leads to everything from seizures,to anxiety,to various toxic states.
So when glutmate becomes a problem over over load this happens,what campral is believed to do is keep that balance shift,which makes it both calming,perhaps gaba level even,and makes u sharp minded,perhaps which is why i get a calm yet talktaive anti depressant lift.
One can only speculate.This med will go with parnate easly,and will go with about every med as wells as not being affected,or AFFECTING THE MED.
No one is out to get you,i wish i had listened myself on zonegran when a babble told me the dopamine thing,i learned the hard way and now i am more prone to listening in general,ur gonna have to have some level of belief that the majority of people here arent out to stop you from getting better,just keep each other safe.
Posted by Phillipa on January 16, 2010, at 22:12:32
In reply to Re: My newest parnate augment, posted by willey on January 16, 2010, at 21:44:35
Hey willey the bioidentical hormone doctor said to buy some gaba for benzos now making me tired. Any idea how this would work? Love Phillipa
Posted by inanimate peanut on January 16, 2010, at 22:54:13
In reply to Re: My newest parnate augment, posted by willey on January 16, 2010, at 21:44:35
Campral is a new drug of interest for me, so keep us posted on how it continues to go. As for the Zonisamide, I will read the dopamine links that were posted on the thread and take your experiences as well into account. Then I'll talk to the doc about my concerns and we'll decide together if it's right for me. I've got pretty firm control on both my psychosis and mixed states right now, so they might be willing to risk it hoping that those will remain controlled. All I know is I'm glad I asked here before going in so I have more of the full picture that you didn't have when you took it. Thanks!
Posted by willey on January 17, 2010, at 0:25:48
In reply to Re: My newest parnate augment » willey, posted by Phillipa on January 16, 2010, at 22:12:32
Well not that i know anything as to what ur doc is saying,what im gathering is this,
Yes when using benzos its a great help to keep natural gaba increased which can prevernt gaba decline from the benzo use,as well as provide the benzos with more raw material to work with.
Gaba over the counter does not work,i promise i spent years learning this,it cant cross the blood brain barrier.
There supplements however that do.To increase gaba u can use l theanine,which increases natural brain gaba,picamilion which increases gaba,and taurine which not directly but indirectly does increase gaba.
These are all over the counter and cross the brain to increase gaba.
Drugs would be useful here,however not everyone can just get any drug they want,but gabpentin def increases gaba,gabatril also.
I forgot valerian is also a potent over the counter gaba ehancer.
These will increase gaba,but benzos dont work by increased gaba,but rather pinging the benzo site.This is why most gaba increasing drugs cant take the place of a benzo.
I use xyrem but thats not an option for u lol in fact it causes much debate.
P.S you posted i migh not have a lot to offer,well personaly i think you should be proud of the direction u have taken,your posts took a 180 and its nice to see,sorry it took that horrendous thread to do so but again you are providing good info latly,thanks.
Posted by willey on January 17, 2010, at 0:43:28
In reply to Re: My newest parnate augment, posted by inanimate peanut on January 16, 2010, at 22:54:13
Well because of its profile stating it has no interaction,in fact it does not affect current meds,and more so current meds dont affect it.
Also with its mild mechanism of action,it seems to be useful to anyone on a anti depressant,my girl added to cymbalta which was dying on her,and unlike me she is able to handle a entire tab,and she is amazed and loving its energy producing effect.
I also wanted to state something,im from brookly lol,so i usualy get defensive fast,but from your post i dident,probuably because i have been where you are,but heres the problem,all people on boards due is provide their opinion and some links,i personaly recomend one never takes a post board to heart,No matter what anyone says here,were not ur doc,so its just an opinion that does not impact what u choose to do,so to post questions and have answers u dont like,make it very infair to verbaly attack someone cause their view is opposite yours.You have the power to do what u want,u and ur doc have the final say,not us..
So if someone posts something u dont agree with i recomend u just thank them for the info,and just ignore it.No one here is a professor,exept me,a professor of b.s lol,so take it at face value.
Just fyi,the way ive come to work in regards to a med i am interested in is this,
First i visit a site like drug bank,and try as much as i can to understand its actual pharmocogly.
I visit a few more such as this.
Then i visit boards,not babble alone,i use babble,i use key words which show tons of foroums with users speaking on it.From this i gather all the pros and cons of user resonse.
I visit wikipedia.
I gather as much info on it from again,PHARMOCOLOGY,USER RESOPONSES ETC.I def dont use this board as a stand alone resource.
That said i think ur lucky,cause i know my docs in the past all of them,would never be willing to add almost anything at all to parnate.
Parnate augmentaion is a hard hard thing to do.Its also a long process,as well as a trial and error,many times i succesed in a cocktail only to have it fail soon after and it was back to the drawing board.But why its done is when a right combo is found,it actualy gives u remission time which is priceless.
Good luck on your meds.
Posted by Phillipa on January 17, 2010, at 19:37:52
In reply to Re: My newest parnate augment, posted by willey on January 17, 2010, at 0:25:48
Willey he suggested Total Health Nutrients.com and name of nutrient Brain Calm. Check it out okay? Let me know what you think. Thanks also. Phillipa
This is the end of the thread.
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