Psycho-Babble Medication Thread 931242

Shown: posts 1 to 25 of 28. This is the beginning of the thread.

 

How come more of you are on parnate than nardil?

Posted by julie1977 on December 28, 2009, at 12:29:04

Just out of curiousity, is it because the side effects are supposed to be less?
Since my success story a day or so ago I feel a bit embarassed as these last few days i've had spells of depression. At this moment I have a depressed feeling in my chest and my head feels cotton-wool like. Hopefully just a minor blip, perhaps its because of xmas and being off work. I feel that work does help to stave depression off somewhat. I anticipate your replies. Julie :-)

 

Re: How come more of you are on parnate than nardil? » julie1977

Posted by Bob on December 28, 2009, at 14:18:47

In reply to How come more of you are on parnate than nardil?, posted by julie1977 on December 28, 2009, at 12:29:04

> Just out of curiousity, is it because the side effects are supposed to be less?
> Since my success story a day or so ago I feel a bit embarassed as these last few days i've had spells of depression. At this moment I have a depressed feeling in my chest and my head feels cotton-wool like. Hopefully just a minor blip, perhaps its because of xmas and being off work. I feel that work does help to stave depression off somewhat. I anticipate your replies. Julie :-)

Good question, Julie. Hopefully someone knows the answer here.

 

Re: How come more of you are on parnate than nardil?

Posted by willey on December 28, 2009, at 15:03:45

In reply to How come more of you are on parnate than nardil?, posted by julie1977 on December 28, 2009, at 12:29:04

Well not sure if thats a fact,however it does seem to be more posting here.I will say this in response to the differance of the two,

--- Parnate unlike nardil,has a very very quick and potent onset usualy in a stimulative form.

--- Parnate is also in genral a more stimulating maoi which might be why some people prefer it.

--- Nardil was actualy once nick named the GOLD STANDERD and was a higly effective med.So much that there were users of 20 years plus stable on it with no issues.

What happened then is a gigantic issue with the drug.There was a major reformualtion that caused a enitre website to form consisting of all types of users from new ones to veteran users stable on the drug for the past 20 years.

What the reformulation did was change some major excipients in the drugs manufacture.The result of this was as i stated a creation of a group of over a hundred users,with complaints of everyhting from the med now being totaly usesless,to the med now actualy causing reverse effects such as various types of sickness.

The overwhelming majority of users quicky discontinued the drug,and as part of the groups daily posts are numerous discussion on how to relicate the drug through alternative med combos
.

Here is the site,on this site it explains more technicaly what happended,as well as the users postings daily,and tons of other info on this nardil problem,


http://www.anxietyhelp.org/treatment/medication/nardil.html?noteListPage=5&noteListSort=Member&noteListMode=0

 

Re: How come more of you are on parnate than nardil?

Posted by bulldog2 on December 28, 2009, at 15:08:49

In reply to How come more of you are on parnate than nardil?, posted by julie1977 on December 28, 2009, at 12:29:04

> Just out of curiousity, is it because the side effects are supposed to be less?
> Since my success story a day or so ago I feel a bit embarassed as these last few days i've had spells of depression. At this moment I have a depressed feeling in my chest and my head feels cotton-wool like. Hopefully just a minor blip, perhaps its because of xmas and being off work. I feel that work does help to stave depression off somewhat. I anticipate your replies. Julie :-)


Julie because of the side effect profile. People generally lose weight or are weight neutral on parnate and parnate tends to be neutral on libido.Some report an increase in libido but some also say it got less but not as bad as nardil.

 

Re: How come more of you are on parnate than nardil?

Posted by julie1977 on December 28, 2009, at 15:26:04

In reply to Re: How come more of you are on parnate than nardil?, posted by bulldog2 on December 28, 2009, at 15:08:49

thanks for your replies. I was aware of the nardil reformulation but have found the 'new' drug to be effective (I wasn't on the old drug). As I have Social Anxiety as well as depression I chose Nardil. I used to weigh 9st and now I weigh 10st 5lbs and this is due to my voracious appetite caused by nardil and olanzapine. I manage to keep my weight reasonable because I do long sessions at the gym four times a week. Think i've gone off the point there.
has anyone tried parnate and nardil?
Thanks Julie

 

Re: How come more of you are on parnate than nardil?

Posted by bulldog2 on December 28, 2009, at 16:08:14

In reply to Re: How come more of you are on parnate than nardil?, posted by julie1977 on December 28, 2009, at 15:26:04

> thanks for your replies. I was aware of the nardil reformulation but have found the 'new' drug to be effective (I wasn't on the old drug). As I have Social Anxiety as well as depression I chose Nardil. I used to weigh 9st and now I weigh 10st 5lbs and this is due to my voracious appetite caused by nardil and olanzapine. I manage to keep my weight reasonable because I do long sessions at the gym four times a week. Think i've gone off the point there.
> has anyone tried parnate and nardil?
> Thanks Julie

I've haven't been on both. Parnate tends to kill your appetite but I don't know how it would combine with zyprexa. Might be a good combo.

 

Re: How come more of you are on parnate than nardil?

Posted by Phillipa on December 28, 2009, at 16:44:13

In reply to Re: How come more of you are on parnate than nardil?, posted by bulldog2 on December 28, 2009, at 16:08:14

Julie are you asking if some of tried nardil and parnate together at the same time?. Phillipa

 

Re: How come more of you are on parnate than nardil?

Posted by bleauberry on December 28, 2009, at 17:38:09

In reply to How come more of you are on parnate than nardil?, posted by julie1977 on December 28, 2009, at 12:29:04

I think overall Nardil seems to have a more difficult side effect profile. More sexual problems, weight gain, tiredness, more hypotension. Generally, but of course mileage varies. It has been a miracle for some. From longterm users they say most of the intense side effects are minimal in the 9 month to 12 month range.

Dr Gillman has a popular psychopharm site. His clinical experience is such that he found Parnate more effective in his career. With over 1000 patients on Parnate, I think he only had 50 on Nardil?

I tell you what though, from what I've seen, when Nardil works, it REALLY works good.

 

Re: How come more of you are on parnate than nardil?

Posted by julie1977 on December 29, 2009, at 4:07:33

In reply to Re: How come more of you are on parnate than nardil?, posted by bleauberry on December 28, 2009, at 17:38:09

thanks again for the further repies :-)
I mean has anyone had separate trials of nardil and of parnate, not taken at the same time
I can't believe i'm still feeling rocky and its been a few days now, its almost like I tempted fate by posting my 'success story'.

 

Re: How come more of you are on parnate than nardil? » julie1977

Posted by Justherself54 on December 29, 2009, at 9:41:00

In reply to Re: How come more of you are on parnate than nardil?, posted by julie1977 on December 29, 2009, at 4:07:33

A short while ago the board had lots of Nardil threads..it seems to go in cycles.

I've had three trials of parnate and one of nardil..I had to go off parnate as I was having major surgery, restarted it and had a severe chilling thing going on. My gp did all kinds of blood work looking for hidden bacteria and stuff from the surgery, but it was the parnate..I felt sick and frozen all the time, so I stopped it. I still wanted to retry it after my nardil trial was a flop, but this time my blood pressure was all over the charts. I was having spontaneous high BP spikes every day..spent a nite in ER, had a holter monitor test and was advised to stop the parnate.

Nardil's side effects were too much. I couldn't hold my urine, had severe urethra inflammation and gained a large amount of weight in the time I was on it. I also vomited in my sleep. When that started happening my pdoc pulled me off it. Around that time there also was a delay of a couple of months where the shipment of Nardil was help up in Canada. I found one drug store in another city that had one bottle of it..another babbler I know was able to get a "compassionate" supply from a prison. It was pretty scary.

Having said all that, if the physical side effects could have been eliminated, I'd go back on Nardil. I was more like my old self, my self-isolating was completely gone, depression gone. I had a lot of fun before the side effects did me in.

I feel I did give them both a fair trial, and as I've said before..they have side effects that are just too much for some people.

I normally don't post on the MAOI threads, as I don't want to be a negative influence, however, it also concerns me when I see some posters continually struggle with these meds, trying to get to the maximum range of dosages, when the side effects are worse than any benefit they are receiving from the drug.

I'm not anti-MAOI, far from it..my pdoc told me they are great meds, unfortunately most of his patients have had to discontinue them due to intolerable side effects.

As with any med, anyone on MAOI's have to decide with their doctors when to try to continue their trials with MAOI's and when to call it quits.

Don't worry about jinxing your trial just because you posted a success story. It may well be just a bump in the road and you'll start feeling better. If not, at least you can say you've given it a fair trial and it just wasn't the med for you. Best of luck and good wishes to you.

 

Re: How come more of you are on parnate than nardi » Justherself54

Posted by Bob on December 29, 2009, at 12:08:29

In reply to Re: How come more of you are on parnate than nardil? » julie1977, posted by Justherself54 on December 29, 2009, at 9:41:00

> A short while ago the board had lots of Nardil threads..it seems to go in cycles.
>
> I've had three trials of parnate and one of nardil..I had to go off parnate as I was having major surgery, restarted it and had a severe chilling thing going on. My gp did all kinds of blood work looking for hidden bacteria and stuff from the surgery, but it was the parnate..I felt sick and frozen all the time, so I stopped it. I still wanted to retry it after my nardil trial was a flop, but this time my blood pressure was all over the charts. I was having spontaneous high BP spikes every day..spent a nite in ER, had a holter monitor test and was advised to stop the parnate.
>
> Nardil's side effects were too much. I couldn't hold my urine, had severe urethra inflammation and gained a large amount of weight in the time I was on it. I also vomited in my sleep. When that started happening my pdoc pulled me off it. Around that time there also was a delay of a couple of months where the shipment of Nardil was help up in Canada. I found one drug store in another city that had one bottle of it..another babbler I know was able to get a "compassionate" supply from a prison. It was pretty scary.
>
> Having said all that, if the physical side effects could have been eliminated, I'd go back on Nardil. I was more like my old self, my self-isolating was completely gone, depression gone. I had a lot of fun before the side effects did me in.
>
> I feel I did give them both a fair trial, and as I've said before..they have side effects that are just too much for some people.
>
> I normally don't post on the MAOI threads, as I don't want to be a negative influence, however, it also concerns me when I see some posters continually struggle with these meds, trying to get to the maximum range of dosages, when the side effects are worse than any benefit they are receiving from the drug.
>
> I'm not anti-MAOI, far from it..my pdoc told me they are great meds, unfortunately most of his patients have had to discontinue them due to intolerable side effects.
>
> As with any med, anyone on MAOI's have to decide with their doctors when to try to continue their trials with MAOI's and when to call it quits.
>
> Don't worry about jinxing your trial just because you posted a success story. It may well be just a bump in the road and you'll start feeling better. If not, at least you can say you've given it a fair trial and it just wasn't the med for you. Best of luck and good wishes to you.
>
>


What were your maximum doses for Nardil and Parnate, if you don't mind me asking?

Bob

 

Re: How come more of you are on parnate than nardi » Bob

Posted by Justherself54 on December 29, 2009, at 15:08:49

In reply to Re: How come more of you are on parnate than nardi » Justherself54, posted by Bob on December 29, 2009, at 12:08:29

First time parnate, I couldn't go over 20 mg. The hypotension was really, really bad. Same with the second..third time 30 (I think), then all the high BP spikes. Nardil 45 mg.

 

Re: How come more of you are on parnate than nardi

Posted by julie1977 on December 29, 2009, at 15:30:58

In reply to Re: How come more of you are on parnate than nardi » Bob, posted by Justherself54 on December 29, 2009, at 15:08:49

Thanks again for your replies.
Justherself, its a shame you had such side effects from Nardil.
I feel daft for waxing lyrical about myself and my recovery now, I hope this mood i'm having now is just a blip, well I say 'mood', it feels like a sensation in my chest. Looking back over my mood diary I can see that I have had other blips, which was why I chose to up my dose from 60mg to 75mg, which has worked well for the last three months.

 

If anyone has any ?s about nardil

Posted by julie1977 on December 29, 2009, at 15:32:26

In reply to Re: How come more of you are on parnate than nardi, posted by julie1977 on December 29, 2009, at 15:30:58

feel free to ask me, I feel like an expert after two years, lol.

 

Re: How come more of you are on parnate than nardi » julie1977

Posted by Justherself54 on December 29, 2009, at 15:43:56

In reply to Re: How come more of you are on parnate than nardi, posted by julie1977 on December 29, 2009, at 15:30:58

Don't feel daft. I raved about my remission with Nardil..then all the bad stuff happened, but that's just in my case.

Have you ever experienced the heaviness in your chest before? How's your blood pressure?

 

Re: How come more of you are on parnate than nardi

Posted by julie1977 on December 29, 2009, at 16:02:50

In reply to Re: How come more of you are on parnate than nardi » julie1977, posted by Justherself54 on December 29, 2009, at 15:43:56

thanks :-)
its one physiological symptoms I have of depression
my bp is fine

 

justherself54

Posted by julie1977 on December 29, 2009, at 16:04:17

In reply to Re: How come more of you are on parnate than nardi, posted by julie1977 on December 29, 2009, at 16:02:50

what meds do you take now, and do they work for you?

 

Re: justherself54 » julie1977

Posted by Justherself54 on December 29, 2009, at 16:30:22

In reply to justherself54, posted by julie1977 on December 29, 2009, at 16:04:17

Unfortunately, I'm nowhere near feeling well. I just did an increase of escitralopram. I also take modafinil which helps a lot. Top that off with .05 clonazapam and 11.25 zopiclone at bedtime and an occasional Tylenol with codeine for pain issues and that's pretty much it in a handbag.

Unfortunately, I'm in a position of having to retry medications that worked before. For now I just hope I get some benefit until it poops out. Not a great place to be, but it's what happens all the time.

I did do some deep house cleaning today, something I've been avoiding for far too long. Who knows, maybe it's a positive sign. Fingers crossed.

 

Re: How come more of you are on parnate than nardil? » julie1977

Posted by Ron Hill on December 29, 2009, at 16:39:15

In reply to Re: How come more of you are on parnate than nardil?, posted by julie1977 on December 29, 2009, at 4:07:33

> I mean has anyone had separate trials of nardil and of parnate, not taken at the same time
---------------

Julie,

I started taking Nardil in the spring of 2006 and continually took it until the spring of 2009 at which point I washed out Nardil and started Parnate. I liked Nardil a lot, but the 50 pound weight gain, ED, and anorgasam caused me to try switching to Parnate.

But, Parnate did not provide any antidepressant action for me. I gave the Parnate trial four months, and I was severely depressed throughout the entire trial. It was hell. So, I washed out the Parnate and restarted Nardil. As soon as I restarted Nardil, my depression reduced to pre-Parnate trial levels.

I am a bipolar II with ultra rapid cycling; 15 day cycle, nine days of full remission, followed by six days of depression. This is my cycle on Nardil. On Parnate, I was always severely depressed.

I take 90 mg/day of Nardil. During my Parnate trial, I ramped up very quickly to 80 mg/day. Perhaps I should have increased to 120 mg/day or higher of Parnate before discontinuing the trial.

-- Ron


dx: Bipolar II with ultra rapid cycling and mild OCPD

600 mg/day Trileptal
200 mg/day Lamictal
500 mg/day Keppra
90 mg/day Nardil
1.9 mg/day Deplin (taken with methyl B-12 and P-5-P)
Dark therapy via LowBlueLight glasses
Exercise: Ride, Lift, Swim, and Sauna
Several vitamins and supplements

 

Re: How come more of you are on parnate than nardil? » Ron Hill

Posted by jedi on December 30, 2009, at 4:06:43

In reply to Re: How come more of you are on parnate than nardil? » julie1977, posted by Ron Hill on December 29, 2009, at 16:39:15

Hi Ron,
Our stories are similar. Nardil knocked out my first major depression over 12 years ago. It was like flipping a switch when it worked. The side effect profile caused me to quit the medication multiple times for other drug trials, including two on Parnate. Out of 45+ different combinations nothing has worked for my atypical depression and social anxiety except phenelzine combined with clonazepam. Both of these meds affect GABA. I have reduced my Nardil from 90mg to 60mg to lower the side effect profile. As it stands now, I'm a lifer on Nardil.

For atypical depression and social anxiety, you will not find a better combination than phenelzine + clonazepam(IMHO). Of course, with the benzodiazepine, don't count on being able to remember what you had for lunch. There are always trade offs.
Good Luck,
Jedi

> > I mean has anyone had separate trials of nardil and of parnate, not taken at the same time
> ---------------
>
> Julie,
>
> I started taking Nardil in the spring of 2006 and continually took it until the spring of 2009 at which point I washed out Nardil and started Parnate. I liked Nardil a lot, but the 50 pound weight gain, ED, and anorgasam caused me to try switching to Parnate.
>
> But, Parnate did not provide any antidepressant action for me. I gave the Parnate trial four months, and I was severely depressed throughout the entire trial. It was hell. So, I washed out the Parnate and restarted Nardil. As soon as I restarted Nardil, my depression reduced to pre-Parnate trial levels.
>
> I am a bipolar II with ultra rapid cycling; 15 day cycle, nine days of full remission, followed by six days of depression. This is my cycle on Nardil. On Parnate, I was always severely depressed.
>
> I take 90 mg/day of Nardil. During my Parnate trial, I ramped up very quickly to 80 mg/day. Perhaps I should have increased to 120 mg/day or higher of Parnate before discontinuing the trial.
>
> -- Ron
>
>
> dx: Bipolar II with ultra rapid cycling and mild OCPD
>
> 600 mg/day Trileptal
> 200 mg/day Lamictal
> 500 mg/day Keppra
> 90 mg/day Nardil
> 1.9 mg/day Deplin (taken with methyl B-12 and P-5-P)
> Dark therapy via LowBlueLight glasses
> Exercise: Ride, Lift, Swim, and Sauna
> Several vitamins and supplements
>

 

Re: Our Love/Hate Relationship with Nardil » jedi

Posted by Ron Hill on December 30, 2009, at 4:41:58

In reply to Re: How come more of you are on parnate than nardil? » Ron Hill, posted by jedi on December 30, 2009, at 4:06:43

Jedi,

I think I'm going to add topiramate (Topamax) due to it's weight loss effect. Further, some studies indicate that topiramate can treat bipolar depression and rapid cycling.

However, Topamax has a lot of possible side effects, one of which is depression.

Has Nardil caused weight gain for you?

-- Ron
-----------------

> Hi Ron,
> Our stories are similar. Nardil knocked out my first major depression over 12 years ago. It was like flipping a switch when it worked. The side effect profile caused me to quit the medication multiple times for other drug trials, including two on Parnate. Out of 45+ different combinations nothing has worked for my atypical depression and social anxiety except phenelzine combined with clonazepam. Both of these meds affect GABA. I have reduced my Nardil from 90mg to 60mg to lower the side effect profile. As it stands now, I'm a lifer on Nardil.
>
> For atypical depression and social anxiety, you will not find a better combination than phenelzine + clonazepam(IMHO). Of course, with the benzodiazepine, don't count on being able to remember what you had for lunch. There are always trade offs.
> Good Luck,
> Jedi
>
> > > I mean has anyone had separate trials of nardil and of parnate, not taken at the same time
> > ---------------
> >
> > Julie,
> >
> > I started taking Nardil in the spring of 2006 and continually took it until the spring of 2009 at which point I washed out Nardil and started Parnate. I liked Nardil a lot, but the 50 pound weight gain, ED, and anorgasam caused me to try switching to Parnate.
> >
> > But, Parnate did not provide any antidepressant action for me. I gave the Parnate trial four months, and I was severely depressed throughout the entire trial. It was hell. So, I washed out the Parnate and restarted Nardil. As soon as I restarted Nardil, my depression reduced to pre-Parnate trial levels.
> >
> > I am a bipolar II with ultra rapid cycling; 15 day cycle, nine days of full remission, followed by six days of depression. This is my cycle on Nardil. On Parnate, I was always severely depressed.
> >
> > I take 90 mg/day of Nardil. During my Parnate trial, I ramped up very quickly to 80 mg/day. Perhaps I should have increased to 120 mg/day or higher of Parnate before discontinuing the trial.
> >
> > -- Ron
> >
> >
> > dx: Bipolar II with ultra rapid cycling and mild OCPD
> >
> > 600 mg/day Trileptal
> > 200 mg/day Lamictal
> > 500 mg/day Keppra
> > 90 mg/day Nardil
> > 1.9 mg/day Deplin (taken with methyl B-12 and P-5-P)
> > Dark therapy via LowBlueLight glasses
> > Exercise: Ride, Lift, Swim, and Sauna
> > Several vitamins and supplements
> >
>
>

 

Re: Our Love/Hate Relationship with Nardil » Ron Hill

Posted by SLS on December 30, 2009, at 6:31:35

In reply to Re: Our Love/Hate Relationship with Nardil » jedi, posted by Ron Hill on December 30, 2009, at 4:41:58

Hi Ron.

> I think I'm going to add topiramate (Topamax) due to it's weight loss effect. Further, some studies indicate that topiramate can treat bipolar depression and rapid cycling.

I actually like Topamax. I have been on it twice, and although it has not made much of an impact on depression, I found it to be a very clean drug with few side effects. Several doctors I have spoken to have observed that cognitive side effects can be minimized by titrating very slowly. I started at 25mg per day and increased by 25mg every week. One could go even slower than that, of course. It seems that if you don't trigger the cognitive side effects in the first place, they can be avoided. 100mg seems to be a good target dose for bipolar disorder. You might need to go to 200mg, but I don't think there is much more benefit to be gleaned at dosages higher than that.

I did notice that my muscles fatigued more quickly. It might be a result of the carbonic anhydrase inhibition. I am not sure. Be sure to drink lots of water to help avoid the production of kidney stones.

Good luck with Topamax. I think it is a good choice. If I do not respond adequately to the addition of Effexor, I might revisit it.


- Scott

 

Re: Our Love/Hate Relationship with Nardil » Ron Hill

Posted by jedi on December 30, 2009, at 18:58:16

In reply to Re: Our Love/Hate Relationship with Nardil » jedi, posted by Ron Hill on December 30, 2009, at 4:41:58

Hi Ron,
I initially gained huge amounts of weight on Nardil. I crave carbohydrates anyway and Nardil compounds the problem. At one point I was over 300 pounds. About 100 pound gain, mostly from Nardil. I was able to take about half of it off through intensive exercise. That is the only thing that has worked for me while taking Nardil.
Good Luck
Jedi


> Jedi,
>
> I think I'm going to add topiramate (Topamax) due to it's weight loss effect. Further, some studies indicate that topiramate can treat bipolar depression and rapid cycling.
>
> However, Topamax has a lot of possible side effects, one of which is depression.
>
> Has Nardil caused weight gain for you?
>
> -- Ron
> -----------------
>
> > Hi Ron,
> > Our stories are similar. Nardil knocked out my first major depression over 12 years ago. It was like flipping a switch when it worked. The side effect profile caused me to quit the medication multiple times for other drug trials, including two on Parnate. Out of 45+ different combinations nothing has worked for my atypical depression and social anxiety except phenelzine combined with clonazepam. Both of these meds affect GABA. I have reduced my Nardil from 90mg to 60mg to lower the side effect profile. As it stands now, I'm a lifer on Nardil.
> >
> > For atypical depression and social anxiety, you will not find a better combination than phenelzine + clonazepam(IMHO). Of course, with the benzodiazepine, don't count on being able to remember what you had for lunch. There are always trade offs.
> > Good Luck,
> > Jedi
> >
> > > > I mean has anyone had separate trials of nardil and of parnate, not taken at the same time
> > > ---------------
> > >
> > > Julie,
> > >
> > > I started taking Nardil in the spring of 2006 and continually took it until the spring of 2009 at which point I washed out Nardil and started Parnate. I liked Nardil a lot, but the 50 pound weight gain, ED, and anorgasam caused me to try switching to Parnate.
> > >
> > > But, Parnate did not provide any antidepressant action for me. I gave the Parnate trial four months, and I was severely depressed throughout the entire trial. It was hell. So, I washed out the Parnate and restarted Nardil. As soon as I restarted Nardil, my depression reduced to pre-Parnate trial levels.
> > >
> > > I am a bipolar II with ultra rapid cycling; 15 day cycle, nine days of full remission, followed by six days of depression. This is my cycle on Nardil. On Parnate, I was always severely depressed.
> > >
> > > I take 90 mg/day of Nardil. During my Parnate trial, I ramped up very quickly to 80 mg/day. Perhaps I should have increased to 120 mg/day or higher of Parnate before discontinuing the trial.
> > >
> > > -- Ron
> > >
> > >
> > > dx: Bipolar II with ultra rapid cycling and mild OCPD
> > >
> > > 600 mg/day Trileptal
> > > 200 mg/day Lamictal
> > > 500 mg/day Keppra
> > > 90 mg/day Nardil
> > > 1.9 mg/day Deplin (taken with methyl B-12 and P-5-P)
> > > Dark therapy via LowBlueLight glasses
> > > Exercise: Ride, Lift, Swim, and Sauna
> > > Several vitamins and supplements
> > >
> >
> >
>
>

 

Re: Our Love/Hate Relationship with Nardil » SLS

Posted by Ron Hill on December 31, 2009, at 6:05:28

In reply to Re: Our Love/Hate Relationship with Nardil » Ron Hill, posted by SLS on December 30, 2009, at 6:31:35

> Hi Ron.

> > I think I'm going to add topiramate (Topamax) due to it's weight loss effect. Further, some studies indicate that topiramate can treat bipolar depression and rapid cycling.

> I actually like Topamax. I have been on it twice, and although it has not made much of an impact on depression, I found it to be a very clean drug with few side effects. Several doctors I have spoken to have observed that cognitive side effects can be minimized by titrating very slowly. I started at 25mg per day and increased by 25mg every week. One could go even slower than that, of course. It seems that if you don't trigger the cognitive side effects in the first place, they can be avoided. 100mg seems to be a good target dose for bipolar disorder. You might need to go to 200mg, but I don't think there is much more benefit to be gleaned at dosages higher than that.

Most studies I've read, and ancedotal reports on this site, indicate that weight loss does not kick-in fully until 175 or 200 mg/day. I hope it does not make me depressed and, thereby, require me to quit the trial.

> I did notice that my muscles fatigued more quickly.

I don't like that.

> It might be a result of the carbonic anhydrase inhibition. I am not sure. Be sure to drink lots of water to help avoid the production of kidney stones.

> Good luck with Topamax. I think it is a good choice. If I do not respond adequately to the addition of Effexor, I might revisit it.

Thanks for the information, Scott. I'd like to save my health insurance company some money by biting 100 mg tablets into four pieces to get my start-up 25 mg doses. There isn't any reason why I should not break the 100 mg tablets, is there?

-- Ron

 

Re: Our Love/Hate Relationship with Nardil » Ron Hill

Posted by SLS on December 31, 2009, at 6:31:11

In reply to Re: Our Love/Hate Relationship with Nardil » SLS, posted by Ron Hill on December 31, 2009, at 6:05:28

Thank you for the information regarding the dosage range used for weight-loss.

> There isn't any reason why I should not break the 100 mg tablets, is there?

I am not aware of any.


- Scott


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