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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by linkadge on November 7, 2009, at 20:32:00
http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0004062
Linkadge
Posted by tensor on November 7, 2009, at 21:20:42
In reply to minserin/mirtazapine may not extend lifespan, posted by linkadge on November 7, 2009, at 20:32:00
> http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0004062
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> LinkadgeTaken together, the net result is zero.
Posted by Phillipa on November 8, 2009, at 0:34:45
In reply to minserin/mirtazapine may not extend lifespan, posted by linkadge on November 7, 2009, at 20:32:00
Remeron and the other is off the market. I took remeron no weight gain or sedation? Phillipa
Posted by SLS on November 8, 2009, at 6:58:50
In reply to minserin/mirtazapine may not extend lifespan, posted by linkadge on November 7, 2009, at 20:32:00
I wonder if the antihistaminergic action of mianserin contributed to the findings. Perhaps pure antihistamines have already been tested and determined to be inert in the nematode paradigm? I wonder how they would have isolated 5-HT receptors as the culprits otherwise. After all, H1 receptor blockade results in increased body weight.
I think I found the answer to this dilemma. It is too bad that the authors didn't address this issue in their paper. Like vertebrates, the invertebrate nematode does express histamine receptors. Unlike vertebrates, however, the nematodes do not express metabotropic receptors such as H1, but rather, are limited to expressing ionophore receptors. So, it turns out that H1 receptors can be ruled-out as the pathway through which lifespan is decreased by nematode exposure to mianserin.
- Scott
Posted by linkadge on November 8, 2009, at 7:29:45
In reply to Re: minserin/mirtazapine may not extend lifespan, posted by SLS on November 8, 2009, at 6:58:50
But doesn't mianserin have less h1 affinity than mirtazapine? Also, both drugs block 5-ht2c which increases appetite.
Linkadge
Posted by SLS on November 8, 2009, at 8:11:05
In reply to Re: minserin/mirtazapine may not extend lifespan, posted by linkadge on November 8, 2009, at 7:29:45
> But doesn't mianserin have less h1 affinity than mirtazapine?
Actually, they are of equal potency.
> Also, both drugs block 5-ht2c which increases appetite.
That's exactly the point of being able to rule-out H1 receptors, which the paper I cited does quite nicely. It lends support to the conclusions of the paper you cited.
- Scott
Posted by TenMan on November 8, 2009, at 8:44:59
In reply to Re: minserin/mirtazapine may not extend lifespan, posted by linkadge on November 8, 2009, at 7:29:45
I could certainly see how the heavy, deadening, sedation that mirtazepine causes could make ones life seem much longer than it really is. Man I hated the way that med made me feel.
Posted by tensor on November 8, 2009, at 11:21:04
In reply to Re: minserin/mirtazapine may not extend lifespan, posted by SLS on November 8, 2009, at 6:58:50
> I wonder if the antihistaminergic action of mianserin contributed to the findings. Perhaps pure antihistamines have already been tested and determined to be inert in the nematode paradigm? I wonder how they would have isolated 5-HT receptors as the culprits otherwise. After all, H1 receptor blockade results in increased body weight.
>
> I think I found the answer to this dilemma. It is too bad that the authors didn't address this issue in their paper. Like vertebrates, the invertebrate nematode does express histamine receptors. Unlike vertebrates, however, the nematodes do not express metabotropic receptors such as H1, but rather, are limited to expressing ionophore receptors. So, it turns out that H1 receptors can be ruled-out as the pathway through which lifespan is decreased by nematode exposure to mianserin.
>
> http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1J-48740FN-1&_user=1515455&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1082962284&_rerunOrigin=google&_acct=C000053262&_version=1&_urlVersion=0&_userid=1515455&md5=535b5eb542907645500e94da90d3b570
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> - ScottEver thought of starting your own pharmaceutical company? ;-)
Posted by linkadge on November 8, 2009, at 11:36:56
In reply to Re: minserin/mirtazapine may not extend lifespan » SLS, posted by tensor on November 8, 2009, at 11:21:04
Perhaps it also depends on whether the animals were permitted to eat an unrestricted number of calories.
Perhaps mirtazapine plus normal caloric intake would still leave an animal feeling starved and in a perceived state of caloric restriction. If the animal is permitted to eat more calories than normal maybe this offsets the effect.
Perhaps this is too simplistic.
Linkadge
Posted by conundrum on November 11, 2009, at 9:08:32
In reply to Re: minserin/mirtazapine may not extend lifespan, posted by linkadge on November 8, 2009, at 11:36:56
Sorry to go off topic, but you seem to know a lot about this drug.
Do any of you know whether Mirtazapine is a 5-HT7 antagonist. Minaserin is so would mirtazapine also be?
This is the end of the thread.
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