![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by zzzz7 on September 8, 2009, at 21:04:31
Who here got really depressed while starting a drug that turned out to be a drug that worked for you? I've been avoiding drugs that make me much more depressed when I take them; I'm wondering if maybe I'm missing out on something that might work.
Posted by manic666 on September 9, 2009, at 3:47:53
In reply to Who got very depressed while starting a drug?, posted by zzzz7 on September 8, 2009, at 21:04:31
you probably are, they all mess you up to start with . jesus you have a strange substance entering your body,these are drugs your body has to ajust to , i was ill for 12 weeks takeing sertraline then it stated working ,you have to run the course unless your the side effects are to much , haveing said that most side effects are sh*t, its up to you if your really ill you try anything an not bail out
Posted by Phillipa on September 9, 2009, at 10:11:41
In reply to Re: Who got very depressed while starting a drug?, posted by manic666 on September 9, 2009, at 3:47:53
Not depressed severed anxiety hence stay on what feels safe even though it doesn't work . Phillipa
Posted by bleauberry on September 9, 2009, at 10:12:54
In reply to Who got very depressed while starting a drug?, posted by zzzz7 on September 8, 2009, at 21:04:31
I have heard of others who started out badly on a med but later on it kicked in nicely.
That never happened to me though. It never got better and usually got worse. The longest I was ever able to hang in there and keep going despite being made far worse on the drug was about 4 weeks. By that time, I was actually worse than a previous episode where I had been hospitalized. Returned back to baseline within 4 days of stopping.
Psych meds have indirect actions on the immune system. I have often wondered if the worsening of depression on an antidepressant is actually a Herxheimer reaction. That is, an enhanced immune system killing a lot of stuff too fast, creating a flood of neurotoxins. I got this hint the last time I tried to start Lexapro, because even though it made me incredibly depressed, longstanding skin infections started to clear up miraculously. There is some connection there I am convinced. Herxheimer reactions feel horrible, with increased depression being at the top of the list. They subside when the majority of the organisms have been killed off. Maybe, just maybe, in some people, that might just happen to be the same time their worsened depression gets better? The Herx is over? Makes me wonder.
But of course, in a simpler theory, if someone does not have a serotonin problem and they take an SSRI, it probably won't feel good. I mean, if it is a chemical imbalance and we throw that chemical imbalance even further out of whack than where it was, ya know?
Posted by zzzz7 on September 9, 2009, at 17:49:17
In reply to Re: Who got very depressed while starting a drug?, posted by bleauberry on September 9, 2009, at 10:12:54
Yeah, I'm worried about crashing and not coming back back to baseline...
On the other hand, maybe I can downregulate oversensitive serotonin receptors if I stay on the AD that makes me depressed long enough.
Posted by alchemy on September 10, 2009, at 21:43:12
In reply to Who got very depressed while starting a drug?, posted by zzzz7 on September 8, 2009, at 21:04:31
I have also heard of people with that response that changes over time. There have been drugs that I couldn't remember why I stopped them that are worth trying again. And often people have a different response when they start a drug again.
But if a drug has definitely made me more depressed, it has not turned around (just my experience)
Posted by zzzz7 on September 11, 2009, at 18:33:55
In reply to Re: Who got very depressed while starting a drug?, posted by alchemy on September 10, 2009, at 21:43:12
Thanks for the response. I've found people that have had changes over time, too. I went from 60-0 almost immediately; don't know what that was about.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.