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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by markwell on July 29, 2009, at 12:20:47
Has anyone heard of a new antidepressant Vilozodone? I believe it has recently been approved or near approval.
Posted by Phillipa on July 29, 2009, at 12:44:19
In reply to vilozodone, posted by markwell on July 29, 2009, at 12:20:47
No is it on google? Phillipa
Posted by Phillipa on July 29, 2009, at 12:49:08
In reply to Re: vilozodone » markwell, posted by Phillipa on July 29, 2009, at 12:44:19
Found this. Phillipa
Posted by markwell on July 29, 2009, at 13:39:45
In reply to Re: vilozodone, posted by Phillipa on July 29, 2009, at 12:49:08
The article doesn't say when it will be available in the states.
Posted by Phillipa on July 29, 2009, at 13:50:30
In reply to Re: vilozodone, posted by markwell on July 29, 2009, at 13:39:45
I read another on too on google think it said sometime 20l0? Will check again. Phillipa sorry about that.
Posted by Phillipa on July 29, 2009, at 13:59:22
In reply to Re: vilozodone, posted by markwell on July 29, 2009, at 13:39:45
Only thing I could find is in phaseIII trials and will submit end of 2009 to FDA. Phillipa so I guess that means still lots of work to be done for approval.
Posted by SLS on July 29, 2009, at 15:03:20
In reply to vilozodone, posted by markwell on July 29, 2009, at 12:20:47
Vilazodone might not appear until next year. The drug company has announced the completion of a phase III trial that demonstrated good results for the treatment of depression.
Vilazodone is a reuptake inhibitor of serotonin and a partial agonist of 5-HT1a receptors.
- Scott
Posted by SLS on July 29, 2009, at 15:13:11
In reply to Re: vilozodone, posted by SLS on July 29, 2009, at 15:03:20
This is a great webpage for listing various investigational psychiatric drugs of the future.
http://www.neurotransmitter.net/newdrugs.html
- Scott
Posted by iforgotmypassword on July 29, 2009, at 18:36:59
In reply to Re: vilozodone, posted by SLS on July 29, 2009, at 15:03:20
> and a partial agonist of 5-HT1a receptors.
in vivo? is this 100% clarified now?
Posted by Phillipa on July 29, 2009, at 20:38:37
In reply to Re: vilozodone » SLS, posted by iforgotmypassword on July 29, 2009, at 18:36:59
That site didn't come up did anyone else get it? Phillipa
Posted by SLS on July 30, 2009, at 5:44:58
In reply to Re: vilozodone » SLS, posted by iforgotmypassword on July 29, 2009, at 18:36:59
> > and a partial agonist of 5-HT1a receptors.
>
> in vivo? is this 100% clarified now?I didn't know there had been some question regarding this. I haven't looked for corroborative evidence of it, though. Since so many studies presume 5-HT1a agonism to be a mechanism, I figured it was considered putative.
It has happened before that the scientific community stated that a particular property of a drug was putative, relying on a single study to determine this. Provigil is an example of this. 5-10 years ago, it was touted as being a NE alpha-1 agonist by all published papers. The origin of this mistaken notion came from one or two preliminary studies.
- Scott
Posted by iforgotmypassword on July 30, 2009, at 9:45:36
In reply to Re: vilazodone » iforgotmypassword, posted by SLS on July 30, 2009, at 5:44:58
on the same info i came across a long time ago:
http://www.dr-bob.org/babble/20090322/msgs/886982.html
i don't know where things have gone since then.
This is the end of the thread.
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