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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by sdb on June 16, 2009, at 11:39:03
trazodone lacks to some extent cardiotoxical effects (mainly compared with TCAs), has less anticholinergic side effects, causes less weight gain, gives no sexual side effects. Why is trazodone's reputation in psychiatry still more the one of a sleep med instead of an anti- depressant/anxiety med? Is the reason lack of efficacy or are there some other side effects not commonly mentioned?
regards
sdb
Posted by Phillipa on June 16, 2009, at 12:11:13
In reply to trazodone. Why isn't it more popular nowadays?, posted by sdb on June 16, 2009, at 11:39:03
I heard it just wasn't a good ad. And then the priapism in men. Other than that don't know. Phillipa
Posted by Amelia_in_StPaul on June 16, 2009, at 12:52:32
In reply to trazodone. Why isn't it more popular nowadays?, posted by sdb on June 16, 2009, at 11:39:03
It is way too sedating at therapeutic levels. I think that is why it is used (at lower levels) only for sleeping. I take 25 mg at night, and that does give me a hangover in the morning. Still, I don't sleep without it.
> trazodone lacks to some extent cardiotoxical effects (mainly compared with TCAs), has less anticholinergic side effects, causes less weight gain, gives no sexual side effects. Why is trazodone's reputation in psychiatry still more the one of a sleep med instead of an anti- depressant/anxiety med? Is the reason lack of efficacy or are there some other side effects not commonly mentioned?
>
> regards
>
> sdb
Posted by Sigismund on June 16, 2009, at 15:19:16
In reply to Re: trazodone. Why isn't it more popular nowadays? » sdb, posted by Amelia_in_StPaul on June 16, 2009, at 12:52:32
It's not available here. There was some toxic metabolite? I forget.
Posted by bleauberry on June 16, 2009, at 15:25:30
In reply to trazodone. Why isn't it more popular nowadays?, posted by sdb on June 16, 2009, at 11:39:03
Lack of efficacy in core depressive symtpoms (pleasure, hobbies, activities, cheerfullness).
Heavy sedation.
Posted by floatingbridge on June 16, 2009, at 16:10:51
In reply to Re: trazodone. Why isn't it more popular nowadays?, posted by bleauberry on June 16, 2009, at 15:25:30
In the morning, I felt like I'd been hit over the head. I suppose that's better than not sleeping at all.....
Posted by jrbecker76 on June 17, 2009, at 19:12:02
In reply to Re: trazodone. Why isn't it more popular nowadays?, posted by floatingbridge on June 16, 2009, at 16:10:51
it's actually being re-studied as an antidepressant.
http://www.medicalnewstoday.com/articles/96780.php
Trazadone is far inferior to its cousin, Serzone (Nefazodone) for depression and tolerability. Despite the liver toxicity issue that arose with Serzone years ago, it is still available in generic form. Many pdocs believe this concern is fairly rare. I have taken a low-dose for years and find it to be a fantastic augmentor.
jb
Posted by yxibow on June 17, 2009, at 23:15:35
In reply to Re: trazodone. Why isn't it more popular nowadays?, posted by jrbecker76 on June 17, 2009, at 19:12:02
In people who may have borderline psychosis, the metabolite of Trazodone, mCPP may precipitate this but this has actually been discounted.
A "normal adult dose" would put most people to sleep all day.
Yes, priapism occurs more than one may think, or at least it did for me, but um... I had ways out of it, lets say standing on your head on a bed is one way :). No -- its a serious situation in older males if it is prolonged and strong, then the penis has to be drained.
And then eventually Serzone came along as mentioned. But it had liver effects unlike Desyrel (trazodone). So the company dropped it, but generic nefazodone is available and does work for some people.
Still I would say that a doctor should monitor liver function on nefazodone every 3-6 months.
-- Jay
Posted by sdb on June 22, 2009, at 15:05:17
In reply to Re: trazodone. Why isn't it more popular nowadays? » sdb, posted by Phillipa on June 16, 2009, at 12:11:13
thanks.
seems to have multiple reasons. I am wondering that serzone should be more effective in spite of the fact that these are chemically related substances.
This is the end of the thread.
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