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Dr. Bob is Robert Hsiung, MD,
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Posted by jhj on May 22, 2009, at 5:16:33
In reply to When will Agomelatine be available in the US, posted by Bob12 on May 20, 2009, at 9:35:26
Can anybody please tell me when Agomelatine will be available in India?Thanks
Posted by Negcreep on May 26, 2009, at 4:51:10
In reply to Re: When will Agomelatine be available in the US, posted by odon on May 21, 2009, at 12:20:41
I am one of the people like Marty who has been ordering Agomelatine from the Ukraine for 6 months now. Works fairly well for my GAD and depression and little to no side effects.
Its difficult to tell you how to go about obtaining agomelatine without breaking the rules of this forum.
But I can always suggest to you to search for said drug in the 'groups' section of a popular internet search engine and take it from there.
Neg
> I was reading some fairly recent posts by Marty.He said he orders Agomelatine by mail from some other country(not sure which country).--I understand this site does not permit people to list sources where they may order medications,however if its a reliable outfit, maybe an exception should be made in this case.And this is coming from a guy(me) that never ordered any medications online,I personally am not comfortable with the idea,but that's me. A sidenote:It's absurd that this medication and certain other possibly effective proven medications are not available in the US and some other countries yet.Why wait,they have been approved in other countries?---The FDA is terrible.If a medication has proven results it should be immediately available in every country.
Posted by Phillipa on May 26, 2009, at 21:06:58
In reply to Re: When will Agomelatine be available in the US » odon, posted by Negcreep on May 26, 2009, at 4:51:10
Neg it has so many member now and people trying the med what's the success rate? Phillipa just curious
Posted by garnet71 on May 26, 2009, at 22:24:34
In reply to When will Agomelatine be available in the US, posted by Bob12 on May 20, 2009, at 9:35:26
It's not cheap - I found it for $125 for one month...
Posted by uncouth on May 27, 2009, at 23:52:36
In reply to Re: When will Agomelatine be available in the US » odon, posted by Negcreep on May 26, 2009, at 4:51:10
I've also been taking it for six months or so, at 50mg, along with other meds. no real side effects, but at the same time, this has been the worst six months of my life, complete with suicidality, so i can't say it's a miracle.
Posted by Negcreep on May 28, 2009, at 9:27:24
In reply to Re: When will Agomelatine be available in the US, posted by uncouth on May 27, 2009, at 23:52:36
Its got about a 60-70% success rate I think. (rough estimate) Some in the group have discontinued its use. So about the same as with other drugs.
My opinion is that its not quite as effective for depression and GAD as an SSRI like citalopram was (in my case), but the lack of side effects makes up for that. I am functional and making it to work etc. But I cant say Im particularly happy in general, and still have some symptoms of GAD and so my life is pretty dull and restricted.
I also have some long term gastritis problems that seem to be caused by SSRI's to begin with. Since stopping them I have found that a lot of other antidperessants including agomelatine still irritate my stomach. I dont know of anyone else with this problem however.
Overall I'd say agomelatine has the potential to help when used alone or in combination with other drugs. If your looking for minimal side effects its definetly worth a look, but as usual its not the 'perfect antidepressant' we're all looking for.
For the time being its the right drug for me.
Neg
Posted by james_ukglasgow on May 30, 2009, at 2:37:09
In reply to Re: When will Agomelatine be available in the US, posted by Negcreep on May 28, 2009, at 9:27:24
I dont know about the US, but it is due to be launched in the UK on 1 June.
You can see the website advertising it here, it contains all the informaiton about it. I dont know how successful it is going to be with the need for a liver function test before it is prescribed then I beleive at 12 weeks then regularly afterwards.
James
Posted by Elanor Roosevelt on May 31, 2009, at 21:19:19
In reply to Re: When will Agomelatine be available in the US, posted by james_ukglasgow on May 30, 2009, at 2:37:09
Valdoxan resynchronizes circadian rhythms in animal models of circadian rhythm disruption.??? what does that mean?
Valdoxan increases noradrenaline and dopamine release specifically in the frontal cortex and has no influence on the extracellular levels of serotonin.
In humans, Valdoxan has positive phase shifting properties; it induces a phase advance of sleep, body temperature decline and melatonin onset. phase shifting????
Posted by desolationrower on June 1, 2009, at 1:10:35
In reply to Re: When will Agomelatine be available in the US, posted by Elanor Roosevelt on May 31, 2009, at 21:19:19
> Valdoxan resynchronizes circadian rhythms in animal models of circadian rhythm disruption.??? what does that mean?
probably to do with melatonin. taking melatonin in the evening entrains the body to be tired in the night, and awake during the day.
> Valdoxan increases noradrenaline and dopamine release specifically in the frontal cortex and has no influence on the extracellular levels of serotonin.
due to 5ht2c antagonism
> In humans, Valdoxan has positive phase shifting properties; it induces a phase advance of sleep, body temperature decline and melatonin onset. phase shifting????
geting sleep cycle normal.
-d/r
Posted by Sigismund on June 3, 2009, at 17:23:41
In reply to Re: When will Agomelatine be available in the US, posted by Elanor Roosevelt on May 31, 2009, at 21:19:19
It has a sedative effect in the evening and (surprisingly) an activating effect in the day.
Posted by Phillipa on June 3, 2009, at 21:23:25
In reply to Re: When will Agomelatine be available in the US, posted by Sigismund on June 3, 2009, at 17:23:41
Member also. Love PJ
Posted by Jimmyboy on June 4, 2009, at 20:56:21
In reply to Re: When will Agomelatine be available in the US » Sigismund, posted by Phillipa on June 3, 2009, at 21:23:25
Any info on how agomelatine is for anxiety or panic attacks?
Posted by Maria3667 on June 5, 2009, at 8:25:37
In reply to Re: When will Agomelatine be available in the US, posted by Jimmyboy on June 4, 2009, at 20:56:21
Not sure about that. I've been on Ago for 12 days now and feel I'm becomming more sensitive (hypersensitive maybe?). But it's early days yet.
Sleep is def. improved!
Maria
> Any info on how agomelatine is for anxiety or panic attacks?
Posted by markwell on June 22, 2009, at 14:28:06
In reply to Re: When will Agomelatine be available in the US » Jimmyboy, posted by Maria3667 on June 5, 2009, at 8:25:37
Is this drug helpful for bipolar depression?
Posted by bearfan on July 9, 2009, at 12:08:53
In reply to Re: When will Agomelatine be available in the US » Jimmyboy, posted by Maria3667 on June 5, 2009, at 8:25:37
Interested in trying this one. I know Stablon is readily available as a supplement, what about this? Which site is trustworthy (Or PM me)
Posted by ninafish on August 20, 2009, at 13:01:52
In reply to Where can Agomelatine/Valdoxan be order overseas?, posted by bearfan on July 9, 2009, at 12:08:53
Can someone please help me with somewhere to order this online? I have been searching and searching to no avail. I am in Australia and my shrink is prepared to prescribe it. I'm desperate. Please help - seathorn@gmail.com
Posted by floatingbridge on October 25, 2009, at 16:11:05
In reply to Where can Agomelatine/Valdoxan be order overseas?, posted by bearfan on July 9, 2009, at 12:08:53
Just wondering. I just googled this, and it sounds promising. Nothing on any site addressed this combination.
Late to the party,
fb
Posted by Rosy Crucifiction on October 25, 2009, at 17:33:37
In reply to Agomelatine/Valdoxan and MAOI? » bearfan, posted by floatingbridge on October 25, 2009, at 16:11:05
I wondered the same thing. Reading Servier's site,it doesn't sound like they're necessarily contraindicated (it says, I recall, that agomelatine doesn't effect extra-cellar serotonin). I've tried emailing them questions before and not gotten a response. Perhaps someone in Europe could do that.
Posted by FredPotter on October 26, 2009, at 16:45:08
In reply to Re: Agomelatine/Valdoxan and MAOI?, posted by Rosy Crucifiction on October 25, 2009, at 18:33:37
I'm confused. I believe Parnate produces N-acetyl-5ht which converts to melatonin. This is why it feels it's time for bed for many of us. If it moved the cycle onward it would explain the insomnia many get, though I don't. So I'm not sure why anyone would want to use a melatonin agonist during the day
Posted by braddock on March 15, 2011, at 4:07:24
In reply to Re: When will Agomelatine be available in the US, posted by markwell on June 22, 2009, at 14:28:06
Posted by braddock on March 15, 2011, at 4:12:00
In reply to Re: When will Agomelatine be available in the US, posted by markwell on June 22, 2009, at 14:28:06
Posted by braddock on March 15, 2011, at 4:13:26
In reply to Re: When will Agomelatine be available in the US (nm), posted by braddock on March 15, 2011, at 4:12:00
I think to get medicine from another country you should know somebody from this country. This one get`s the medicine from a doctor or is a doctor by himself or go other ways.
I am from Germay. ;-)
Posted by braddock on March 15, 2011, at 4:13:56
In reply to Re: When will Agomelatine be available in the US (nm), posted by braddock on March 15, 2011, at 4:12:00
I think to get medicine from another country you should know somebody from this country. This one get`s the medicine from a doctor or is a doctor by himself or go other ways.
I am from Germay. ;-)
Posted by Phillipa on March 15, 2011, at 19:40:23
In reply to Re: When will Agomelatine be available in the US, posted by braddock on March 15, 2011, at 4:13:56
I think available second half of year in USA. Phillipa
Posted by europerep on March 16, 2011, at 7:58:07
In reply to Re: When will Agomelatine be available in the US, posted by Phillipa on March 15, 2011, at 19:40:23
> I think available second half of year in USA. Phillipa
nope that's vilazodone. agomelatine won't be submitted to the FDA before 2012, so I guess it'll arrive in 2013, maybe 2014.
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