Psycho-Babble Medication Thread 894445

Shown: posts 1 to 9 of 9. This is the beginning of the thread.

 

Benzos heading towards a good place

Posted by shasling on May 6, 2009, at 5:48:00

Most wont disagree the common bensos are best for chemical depression,how the motorskills and sedation and depression seems to scare people off from using them.

Well on the pipeline as we speak is a brand new benzo med,so now it is just refercened as a number now with no actual brand name.

This benzo is unique because appearntly they are on the verge of being more precise on the benzo sitees,the goal of this med is to offer anxiety relieaf as most benzos do,however being so selective avoid comptly the sedation side effect.

I believe its this one right here but i could be wron,the one i saw was so new it did not even have a actual name for it.Heres a snip of another i found as well as the link

"" Imidazenil is an anxiolytic drug which is derived from the benzodiazepine family, and is most closely related to other imidazobenzodiazepines such as midazolam, flumazenil and bretazenil.

Imidazenil is a GABAA partial agonist[1] with an unusual profile of effects, producing some of the effects associated with normal benzodiazepines such as anticonvulsant and anxiolytic effects, yet without any notable sedative[2] or amnestic[3] effects. In fact, imidazenil blocks the sedative effects of diazepam, yet without lowering the convulsion threshold,[4] and so potentially could be a more flexible antidote than the antagonist flumazenil which is commonly used to treat benzodiazepine overdose at present.

This unusual profile of effects makes imidazenil potentially a very useful drug. In animal studies it has been shown to be an effective anxiolytic and strong anticonvulsant, yet without many of the side effects associated with other benzodiazepines; it does not produce tolerance[5] or dependence,[6] reverses the amnestic effects of conventional benzodiazepines, and does not potentiate the effects of alcohol.[7][8]

Imidazenil has not yet been developed commercially for use in humans, however it has been suggested as a safe and effective treatment for anxiety,[9] a potent yet non-sedating anticonvulsant which might be particularly useful in the treatment of poisoning with organophosphate nerve agents,[10][11] and as a novel treatment for schizophrenia

This unusual profile of effects makes imidazenil potentially a very useful drug. In animal studies it has been shown to be an effective anxiolytic and strong anticonvulsant, yet without many of the side effects associated with other benzodiazepines; it does not produce tolerance[5] or dependence,[6] reverses the amnestic effects of conventional benzodiazepines, and does not potentiate the effects of alcohol.[7][8]

Imidazenil has not yet been developed commercially for use in humans, however it has been suggested as a safe and effective treatment for anxiety,[9] a potent yet non-sedating anticonvulsant which might be particularly useful in the treatment of poisoning with organophosphate nerve agents,[10][11] and as a novel treatment for schizophrenia.[12]

Heres the link
http://en.wikipedia.org/wiki/Imidazenil

 

Re: Benzos heading towards a good place shasling

Posted by SLS on May 6, 2009, at 7:52:19

In reply to Benzos heading towards a good place, posted by shasling on May 6, 2009, at 5:48:00

Hi Shasling.

> Heres the link
> http://en.wikipedia.org/wiki/Imidazenil

Good find.

Thanks.


- Scott

 

Re: Benzos heading towards a good place

Posted by Phillipa on May 6, 2009, at 10:49:33

In reply to Re: Benzos heading towards a good place shasling, posted by SLS on May 6, 2009, at 7:52:19

Some hope? Love Phillipa

 

Re: Benzos heading towards a good place

Posted by shasling on May 6, 2009, at 23:04:17

In reply to Re: Benzos heading towards a good place, posted by Phillipa on May 6, 2009, at 10:49:33

Yess of course,to recreate a benzo with the samer potentency and anxiety relieaf,but lacking sedation dullness and worsened depression would be a huge movment forward.

In fact this new benzo on the wiki sheet even states it doesent potentiate liqour which is a very very far cry from your benzo of today

 

Re: Benzos heading towards a good place shasling

Posted by Phillipa on May 7, 2009, at 19:55:06

In reply to Re: Benzos heading towards a good place, posted by shasling on May 6, 2009, at 23:04:17

Sure is especially when now tolerant and they do nothing. Phillipa

 

Re: Benzos heading towards a good place

Posted by breakman on May 9, 2009, at 9:07:28

In reply to Re: Benzos heading towards a good place shasling, posted by Phillipa on May 7, 2009, at 19:55:06

Sounds to me a lot like Ocinaplon which had
the exact characteristics.

In addition to not causing sleepiness or
tolerance it (allegedly) had a greater
anxiolytic effect than comparable benzos.

I followed the clinical trials for many years
with great anticipation. Unfortunately, it
caused an adverse liver reaction in a one
subject in a phase 2 clinical trial and was
withdrawn.

I hope this medication avoids these issues.

A medication with this profile (especially
the non-tolerance part would be
revolutionary).

I am always skeptical when these new meds
tout non-tolerance. There are so few meds
that do not result in tolerance.

 

Re: Benzos heading towards a good place breakman

Posted by Phillipa on May 9, 2009, at 20:13:41

In reply to Re: Benzos heading towards a good place, posted by breakman on May 9, 2009, at 9:07:28

Agree how many years did they work for you? Phillipa

 

Re: Benzos heading towards a good place

Posted by shasling on May 11, 2009, at 21:50:33

In reply to Re: Benzos heading towards a good place, posted by breakman on May 9, 2009, at 9:07:28

Would be one hell of a med huh,doesent even ineract or poteniate acholol lol,well we will wait and see i suppose.

 

Re: Benzos heading towards a good place

Posted by desolationrower on May 13, 2009, at 3:09:16

In reply to Re: Benzos heading towards a good place, posted by shasling on May 11, 2009, at 21:50:33

they've got meds like this now in france, forget the name, i think etifoxine or something. never could get a hlold of it though don't have personal xperinc

-d/r


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