![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by NickCave on March 10, 2009, at 14:10:33
Has anyone tried combining a low dose of doxepin with lexapro for sleep. I currently take 10mg lexapro and have been using either generic benedryl or unisom to help me sleep. these work really well for 3-4 days, then they seem to lose their effectiveness. My pdoc wants to add 10mg of doxepin to help me sleep. should I be concerned about tca side effects at this low dose? has anyone successfully used this combo?
Posted by Phillipa on March 10, 2009, at 15:43:43
In reply to Lexapro with doxepin for sleep, posted by NickCave on March 10, 2009, at 14:10:33
If you're looking for tca pamelor at l0mg knocked me literally out and didn't get up til after 2pm next day. Phillipa
Posted by desolationrower on March 11, 2009, at 2:18:04
In reply to Re: Lexapro with doxepin for sleep » NickCave, posted by Phillipa on March 10, 2009, at 15:43:43
really i don't see why you wouldn't use cyproheptadine. better evidence that it improves sleep architecture, short halflife so you don't wake up hung over, its dirt cheap.
at low doses doxepin is just an antihistamine, not as crap as benedryl, but still.
-d/r
Posted by NickCave on March 11, 2009, at 6:00:39
In reply to Re: Lexapro with doxepin for sleep, posted by desolationrower on March 11, 2009, at 2:18:04
> really i don't see why you wouldn't use cyproheptadine. better evidence that it improves sleep architecture, short halflife so you don't wake up hung over, its dirt cheap.
>
> at low doses doxepin is just an antihistamine, not as crap as benedryl, but still.
>
> -d/risn't cyproheptadine a serotonin antagonist? wouldn't it be working against the lexapro?
Posted by desolationrower on March 11, 2009, at 10:08:59
In reply to Re: Lexapro with doxepin for sleep, posted by NickCave on March 11, 2009, at 6:00:39
> > really i don't see why you wouldn't use cyproheptadine. better evidence that it improves sleep architecture, short halflife so you don't wake up hung over, its dirt cheap.
> >
> > at low doses doxepin is just an antihistamine, not as crap as benedryl, but still.
> >
> > -d/r
>
> isn't cyproheptadine a serotonin antagonist? wouldn't it be working against the lexapro?there are many serotonin receptors, in various locations. the increased serotonin from an sri hits all of them, but only some contribute to the therapeutic effects. some contribute so side effects. in this case, it will 'work against' the negative effects on sleep quality.
-d/r
Posted by clipper40 on March 13, 2009, at 5:22:19
In reply to Re: Lexapro with doxepin for sleep, posted by desolationrower on March 11, 2009, at 10:08:59
Doesn't cyproheptadine increase appetite a lot? But then, I guess doxepin increases it as well, doesn't it?
Posted by mav27 on March 13, 2009, at 16:02:48
In reply to Re: Lexapro with doxepin for sleep » desolationrower, posted by clipper40 on March 13, 2009, at 5:22:19
> Doesn't cyproheptadine increase appetite a lot? But then, I guess doxepin increases it as well, doesn't it?
Doxepin sent my appetite through the roof. I put on 10kg in just a week... gave the stuff up after that.
cyproheptadine didn't do that to me, but it also didn't make me sleepy.
Posted by desolationrower on March 14, 2009, at 21:45:50
In reply to Re: Lexapro with doxepin for sleep » clipper40, posted by mav27 on March 13, 2009, at 16:02:48
well, i suppose. you're supposed to be asleep when that happens though :)
-d/r
Posted by clipper40 on March 16, 2009, at 5:40:44
In reply to Re: Lexapro with doxepin for sleep, posted by desolationrower on March 14, 2009, at 21:45:50
Posted by clipper40 on March 16, 2009, at 5:41:52
In reply to Re: Lexapro with doxepin for sleep » clipper40, posted by mav27 on March 13, 2009, at 16:02:48
Interesting. Doxepin definitely increased my appetite as well but nothing like what you experienced.
Posted by West on March 16, 2009, at 10:45:21
In reply to Re: Lexapro with doxepin for sleep » mav27, posted by clipper40 on March 16, 2009, at 5:41:52
Cyproheptadine made my depression return to very near its full force. I took it with lexapro. Be careful with that.
West
Posted by NickCave on March 17, 2009, at 6:17:27
In reply to Re: Lexapro with doxepin for sleep, posted by West on March 16, 2009, at 10:45:21
I was wondering about that. it doesn't seem like a good long term sleeping solution.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.