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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Roslynn on February 12, 2009, at 17:43:01
Did anyone get second-day depression from this med as a side effect and does it go away?
Thanks for any info.
Roslynn
Posted by SLS on February 13, 2009, at 9:13:20
In reply to Second-day depression from Trazodone?, posted by Roslynn on February 12, 2009, at 17:43:01
> Did anyone get second-day depression from this med as a side effect and does it go away?
>
> Thanks for any info.
>
> Roslynn
Hi Roslynn.I am unsure what you mean. What are you taking trazodone for? Can you describe what you mean by "second-day depression"? What are you experiencing?
- Scott
Posted by Roslynn on February 13, 2009, at 10:25:32
In reply to Re: Second-day depression from Trazodone? » Roslynn, posted by SLS on February 13, 2009, at 9:13:20
> Hi Roslynn.
>
> I am unsure what you mean. What are you taking trazodone for? Can you describe what you mean by "second-day depression"? What are you experiencing?
>
>
> - ScottHi Scott,
In the past I have felt more depressed the next day after taking trazodone the night before for sleep. My doc may want me to start taking it again (cause we're running out of options) and I'm just wondering if anyone else has had this side effect and if it goes away eventually.
Thanks,
Roslynn
Posted by SLS on February 13, 2009, at 12:56:12
In reply to Re: Second-day depression from Trazodone?, posted by Roslynn on February 13, 2009, at 10:25:32
> > Hi Roslynn.
> >
> > I am unsure what you mean. What are you taking trazodone for? Can you describe what you mean by "second-day depression"? What are you experiencing?
> >
> >
> > - Scott
>
> Hi Scott,
>
> In the past I have felt more depressed the next day after taking trazodone the night before for sleep. My doc may want me to start taking it again (cause we're running out of options) and I'm just wondering if anyone else has had this side effect and if it goes away eventually.
>
> Thanks,
> Roslynn
I found trazodone to be a pretty disgusting drug. I felt a "hangover" the morning after taking it for sleep. However, this hangover effect was not the same as the original depression getting worse. I think the hangover thing can get somewhat better over time, but if your core depressive illness is made worse, I would not expect that to get better.Trazodone has a metabolite known as mCPP. It can produce dysphoria and anxiety. Perhaps this is what is going on here.
Why do you need a hyponotic (sleeping pill)?
What have you tried?
Do you have problems falling asleep or staying asleep or both?
How much Ativan have you tried taking?
- Scott
Posted by Roslynn on February 13, 2009, at 16:20:00
In reply to Re: Second-day depression from Trazodone? » Roslynn, posted by SLS on February 13, 2009, at 12:56:12
> I found trazodone to be a pretty disgusting drug. I felt a "hangover" the morning after taking it for sleep. However, this hangover effect was not the same as the original depression getting worse. I think the hangover thing can get somewhat better over time, but if your core depressive illness is made worse, I would not expect that to get better.
>
> Trazodone has a metabolite known as mCPP. It can produce dysphoria and anxiety. Perhaps this is what is going on here.
>
> Why do you need a hyponotic (sleeping pill)?
>
> What have you tried?
>
> Do you have problems falling asleep or staying asleep or both?
>
> How much Ativan have you tried taking?
>
>
> - ScottHi Scott,
Thank you for the information.
I have problems staying asleep even with 3mg ativan and 100mg Seroquel each night. My pdoc says I'm taking too much ativan (a total of 4-5 mg per day) so he'd rather I increase the seroquel, but that results in cognitive problems for me. I tried Valium a few days ago to disastrous results.I get nightmares from regular sleeping pills like Ambien or Restoril, lunesta and benedryl.
Thanks,
Roslynn
Posted by raisinb on February 14, 2009, at 11:29:44
In reply to Second-day depression from Trazodone?, posted by Roslynn on February 12, 2009, at 17:43:01
You know, I'm not sure what aspect of Trazodone causes sleepiness, but if it's anything similar to Remeron (antihistaminic effect, I think) or OTC drugs like Unisom or Sleepinal, then I think that can happen. I have never tried Trazodone. But with Remeron and OTC meds, I got very hung over and depressed the next day. I'd cry over any little thing and feel like life didn't have much meaning available for me. I felt sluggish and unable to think.
Posted by theo on February 14, 2009, at 17:13:57
In reply to Re: Second-day depression from Trazodone? » Roslynn, posted by raisinb on February 14, 2009, at 11:29:44
What dose of Trazodone are you taking?
I've been trying a small dose (25mg)of Trazodone at night for a couple of weeks in addition to Wellbutrin XL. I have found that the first few days for me were great for anxiety relief, but I am now experiencing more anxiety by 5:00pm, I guess because of the short half life. It was such a small dose I didn't think it would bother me to just stop, but I skipped a night and was extremely tense and on edge, felt like I was going nuts.
Posted by bleauberry on February 14, 2009, at 17:25:05
In reply to Second-day depression from Trazodone?, posted by Roslynn on February 12, 2009, at 17:43:01
I definitely felt more depressed the following day after using traz. I kept telling myself it was the drug's hangover side effect that would go away as I got used to the drug, or that it was carryover sedation/lethargy. But no, it wasn't those. I was genuinely down in the dumps, apart from any little bit of lethargy that went along with it.
I also did not find it to be a particularly good sleep aid. It might have helped me fall asleep faster, but sleep was light and disturbed, with early waking.
In terms of using ADs for sleep, I would far prefer something like 10mg-25mg Amytriptyline, 10mg-25mg Nortriptyline, or 7.5mg Remeron, with Remeron being my first choice. For me it has the morning hangover thing still, but not the second day depression thing. Other more benign sleep aids, even though they are potent meds at higher doses, are Seroquel 25mg or Zyprexa 2.5mg.
Some people find traz a very beneficial benign sleep aid. I am not one of them. If I wanted to feel really glum and blue the next day, more than usual, I could just take a traz. I'm glad it doesn't affect everyone that way.
Posted by Roslynn on February 14, 2009, at 17:40:54
In reply to Second-day depression from Trazodone?, posted by Roslynn on February 12, 2009, at 17:43:01
Thanks everyone for your help. At least I know it's not just me. I will look into different options.
Thanks,
Roslynn
Posted by SLS on February 21, 2009, at 6:41:43
In reply to Re: Second-day depression from Trazodone?, posted by Roslynn on February 14, 2009, at 17:40:54
For what it is worth, trazodone is metabolized by the body into a compound named mCPP (m-Chlorophenylpiperazine). This substance is known to produce anxiety and dysphoria. My guess is that as the trazodone levels drop and the levels of mCPP remain elevated at the end of a dosing period, the dysphoria and anxiety will predominate over the hypnotic effect. Smoking makes this disparity worse.
- Scott
Posted by SLS on February 21, 2009, at 6:43:22
In reply to Re: Second-day depression from Trazodone?, posted by SLS on February 21, 2009, at 6:41:43
Scott, you dummy. You wrote that already!
> For what it is worth, trazodone is metabolized by the body into a compound named mCPP (m-Chlorophenylpiperazine). This substance is known to produce anxiety and dysphoria. My guess is that as the trazodone levels drop and the levels of mCPP remain elevated at the end of a dosing period, the dysphoria and anxiety will predominate over the hypnotic effect. Smoking makes this disparity worse.
>
>
> - Scott
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