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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Questionmark on October 31, 2008, at 18:44:06
I have been asked if I would be interested in participating (if I was accepted, of course) in a late phase placebo-controlled study on the RIMA (reversible inhibitor of MAO-A) Tyrima. There is no monetary compensation and I would have to forgo Nardil for awhile. Since, based on what i've read, it doesn't seem to be any more special than moclobemide (except for a somewhat longer half-life), I'm probably not even going to bother. But I am somewhat curious (besides it being for a good cause of sorts, more or less).
Fellow Babblers, your opinions: yay or nay?
Posted by Phillipa on October 31, 2008, at 19:38:53
In reply to Tyrima study, posted by Questionmark on October 31, 2008, at 18:44:06
Gee it is a wonderful opportunity as these are the new meds. I'd say go for it unless your meds are working so well you don't want to risk them not working again. Tough decision. Phillipa
Posted by bleauberry on October 31, 2008, at 19:46:47
In reply to Tyrima study, posted by Questionmark on October 31, 2008, at 18:44:06
Hard to say. Drugs are so different. Even ones extremely similar to each other, such as celexa (citalopram) versus lexapro (escitalopram), produce different results in different people. Moclobemide and this new drug are completely different, though they may share the same "supposed" mechanism. It is worth mentioning that all these drugs do a ton of other stuff besides the simple neurotransmitter mechanics we talk about here, and each drug is very different in how it orchestrates genetic coding.
If you do the trial, just keep in mind, you might be one of the 50% who get a placebo and not the drug.
Posted by Medline on November 1, 2008, at 14:12:22
In reply to Re: Tyrima study, posted by bleauberry on October 31, 2008, at 19:46:47
I don't quite get it: Is Tyrima a simple reversible MAO-A inhibitor? Then how is it superior to Moclobemide? A brain selective MAO-A+MAO-B inhibitor would be a novel agent.
Posted by Questionmark on November 3, 2008, at 1:03:32
In reply to Re: Tyrima study, posted by Medline on November 1, 2008, at 14:12:22
> I don't quite get it: Is Tyrima a simple reversible MAO-A inhibitor? Then how is it superior to Moclobemide? A brain selective MAO-A+MAO-B inhibitor would be a novel agent.
See, that's exactly what I was thinking Medline. I couldn't really find much info on it, but based on the little I could it doesn't seem to have any qualities beyond half-life that would seem to make it superior to moclobemide at all.
But, that said, bleauberry brings up a very good point in that just because two drugs are in the same specific class doesn't mean they are going to be exactly the same. The irreversible MAOIs are a great example of this. But, with Parnate and Nardil we are aware of some of their different pharmacological properties-- as is even the case with some of the SSRIs-- but with moclobemide and Tyrima i am not yet aware of any differences. So, i dunno.
Posted by Questionmark on November 3, 2008, at 1:06:53
In reply to Re: Tyrima study » Questionmark, posted by Phillipa on October 31, 2008, at 19:38:53
It is a somewhat neat opportunity, but it doesn't seem to be all that novel of a drug at all.
But yeah it still is a kind of tough decision.> Gee it is a wonderful opportunity as these are the new meds. I'd say go for it unless your meds are working so well you don't want to risk them not working again. Tough decision. Phillipa
Posted by Medline on November 3, 2008, at 4:52:46
In reply to Re: Tyrima study » Phillipa, posted by Questionmark on November 3, 2008, at 1:06:53
The drug Ladostigil seems to be a cholinesterase-inhibitor and a CNS-selective MAO-A+B inhibitor. I think this drug will rock!
Posted by Questionmark on November 5, 2008, at 21:08:20
In reply to Ladostigil, posted by Medline on November 3, 2008, at 4:52:46
> The drug Ladostigil seems to be a cholinesterase-inhibitor and a CNS-selective MAO-A+B inhibitor. I think this drug will rock!
Yeah, that is awesome. That would be very interesting. Is it a so called irreversible MAOI or reversible?
Posted by diego on November 20, 2008, at 19:05:58
In reply to Tyrima study, posted by Questionmark on October 31, 2008, at 18:44:06
I'm taking part in this study but it's too early to gauge any results. If I had to guess, I'd say I got the real thing and not a placebo based on 2 factors: urinary frequency and a heightened response to adrenaline from a scare or sudden stress.
This is the end of the thread.
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