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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by moviemom on March 14, 2008, at 14:44:33
I am interested in the possible link between cytokines, inflammation, and depression. Anyone have any infrormation?
Posted by seldomseen on March 14, 2008, at 15:19:17
In reply to Cytokines, Inflammation, and Depression, posted by moviemom on March 14, 2008, at 14:44:33
there actually are a ton of articles about it on pubmed
www.pubmed.com
search on cytokines AND inflammation AND depression
here is one recent review article that summarizes some of the research in this area I'm sure
If you can't open the article, bmail me and I will send it to youSeldom
Posted by Phillipa on March 14, 2008, at 17:11:42
In reply to Re: Cytokines, Inflammation, and Depression » moviemom, posted by seldomseen on March 14, 2008, at 15:19:17
Heard they also affect cholesterol levels I think will try the article now Phillipa
Posted by moviemom on March 14, 2008, at 17:21:02
In reply to Re: Cytokines, Inflammation, and Depression » moviemom, posted by seldomseen on March 14, 2008, at 15:19:17
Thanks. Are you aware of any treatments (conventional or otherwise) that target inflammation or cytokine reduction as a means of treating depression?
Posted by Phillipa on March 14, 2008, at 17:21:03
In reply to Re: Cytokines, Inflammation, and Depression » seldomseen, posted by Phillipa on March 14, 2008, at 17:11:42
This one I did a search so how do you reduce them especially if genes are involved? Phillipa
Performing your original search, Cytokines, inflammation, depression, in PubMed will retrieve 485 citations.
Display SummaryBriefAbstractAbstractPlusCitationMEDLINEXMLUI ListLinkOutASN.1Related ArticlesCited in BooksCancerChrom LinksDomain Links3D Domain LinksGEO DataSet LinksGene LinksGene (OMIM) LinksGene (GeneRIF) LinksGenome LinksProject LinksGENSAT LinksGEO Profile LinksHomoloGene LinksCoreNucleotide LinksCoreNucleotide (RefSeq) LinksEST LinksEST (RefSeq) LinksGSS LinksGSS (RefSeq) LinksNucleotide LinksNucleotide (RefSeq) LinksOMIA LinksOMIM (calculated) LinksOMIM (cited) LinksBioAssay LinksCompound LinksCompound (MeSH Keyword)Compound (Publisher) LinksSubstance LinksSubstance (MeSH Keyword)Substance (Publisher) LinksPMC LinksCited in PMCPopSet LinksProbe LinksProtein LinksProtein (RefSeq) LinksProtein Cluster LinksCited ArticlesSNP LinksStructure LinksTaxonomy via GenBankUniGene LinksUniSTS Links Show 5102050100200500Sort ByPub DateFirst AuthorLast AuthorJournalSend toTextFilePrinterClipboardE-mailOrderAll: 1 Review: 1 Click to change filter selection through MyNCBI.
1: Trends Immunol. 2006 Jan;27(1):24-31. Epub 2005 Nov 28. Links
Cytokines sing the blues: inflammation and the pathogenesis of depression.Raison CL, Capuron L, Miller AH.
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA.Increasing amounts of data suggest that inflammatory responses have an important role in the pathophysiology of depression. Depressed patients have been found to have higher levels of proinflammatory cytokines, acute phase proteins, chemokines and cellular adhesion molecules. In addition, therapeutic administration of the cytokine interferon-alpha leads to depression in up to 50% of patients. Moreover, proinflammatory cytokines have been found to interact with many of the pathophysiological domains that characterize depression, including neurotransmitter metabolism, neuroendocrine function, synaptic plasticity and behavior. Stress, which can precipitate depression, can also promote inflammatory responses through effects on sympathetic and parasympathetic nervous system pathways. Finally, depression might be a behavioral byproduct of early adaptive advantages conferred by genes that promote inflammation. These findings suggest that targeting proinflammatory cytokines and their signaling pathways might represent a novel strategy to treat depression.
PMID: 16316783 [PubMed - indexed for MEDLINE]
Posted by Dopamine123 on March 14, 2008, at 17:46:43
In reply to Cytokines, Inflammation, and Depression, posted by moviemom on March 14, 2008, at 14:44:33
Check out the post in this forum. The site is currently down, but it should be back up soon.
http://www.abolitionist-society.com/forum/viewtopic.php?t=1199&highlight=A Pilot Study of Infliximab for Treatment Resistant Major Depression (infliximab)
http://clinicaltrials.gov/ct2/show/NCT00463580?term=TNF+depression+mood&rank=1Cox-2 inhibitors have antidepressant properties.
Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder:
http://www.ncbi.nlm.nih.gov/pubmed/18172906?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumAspirin might also have antidepressant properties
http://www.ncbi.nlm.nih.gov/pubmed/8730644
>Aspirin use was found to be associated with less depression and anxiety or worry, as reported by the patient and as perceived by a significant other.Curcumin can be bought as a supplement. It has anti-inflammatory properties.
Antidepressant effects of curcumin in the forced swim test
http://www.ncbi.nlm.nih.gov/pubmed/16171853?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Posted by seldomseen on March 14, 2008, at 19:02:37
In reply to Re: Cytokines, Inflammation, and Depression, posted by moviemom on March 14, 2008, at 17:21:02
Fish oils have been used as both a treatment for depression and they are thought to alleviate depression (they work with me)
You can search the pubmed database and look though for additional ones
Seldom
Posted by seldomseen on March 14, 2008, at 19:03:34
In reply to Re: Cytokines, Inflammation, and Depression, posted by moviemom on March 14, 2008, at 17:21:02
Fish oils have been used as both a treatment for depression and they are thought to alleviate depression (they work with me)
You can search the pubmed database and look though for additional ones
Seldom
Posted by moviemom on March 14, 2008, at 19:19:14
In reply to Re: Cytokines, Inflammation, and Depression » moviemom, posted by seldomseen on March 14, 2008, at 19:03:34
Thanks for the links and information. How much DHA and EPA do you take?
Posted by bleauberry on March 15, 2008, at 10:56:53
In reply to Cytokines, Inflammation, and Depression, posted by moviemom on March 14, 2008, at 14:44:33
Personally I have no doubt there is a link between chronic hidden inflammation and depression. Not always, but sometimes I notice I get a pretty good mood after taking tylenol or advil. People have been cured by taking borage oil to increase GLA (anti-inflammatory). Fish oils or flax oils can sometimes help that too. If you do a search on inflammation and herbs there a bunch. I think common ones are ginger, cucumin, and licorice.
Where the inflammation is coming from is a whole different story. Could be a hundred different possibilities ranging from heavy metals to food intolerances/sensitivities to candida to parasites to autoimmune diseases and on and on. Whatever the cause, if there is inflammation then bringing it down should help body and mind in noticeable ways.
I remember reading a story of someone being treated naturally for depression. She went through the whole cycle of 5htp, then typrosine, then dlpa, and gaba. She was then switched to borage oil instead and completely recovered within 3 days. Her depression was not a neurotransmitter deficiency, but rather some unknown inflammation that GLA countered. There was someone here a couple months ago that also got significant benefit from borage oil when all kinds of other supplement trials didn't do anything good.
Posted by moviemom on March 15, 2008, at 14:30:04
In reply to Re: Cytokines, Inflammation, and Depression, posted by bleauberry on March 15, 2008, at 10:56:53
Thanks. Do you know what dosage of borage oil (or GLA) should be effective?
Posted by Jimmyboy on March 17, 2008, at 18:47:50
In reply to Re: Cytokines, Inflammation, and Depression, posted by bleauberry on March 15, 2008, at 10:56:53
Yep, I have been virtually cured by taking Borage OIl + aspirin. I had been on Lithium and every other nasty antidepressant for over 13 years. It has been nothing short of a miracle for me. My inflammation problem is caused by food intolerances - namely gluten and corn ( uh yeah, can;t eat anything since every food known to man has corn syrup in it)
Anyway, GLA can increase prostaglandin-1 which has anti-inflammatory efects. Try it out, can;t hurt.
Posted by moviemom on March 18, 2008, at 9:51:51
In reply to Re: Cytokines, Inflammation, and Depression » bleauberry, posted by Jimmyboy on March 17, 2008, at 18:47:50
Thanks. How much borage oil and aspirin do you use each day?
Posted by Jimmyboy on March 23, 2008, at 22:12:39
In reply to Re: Cytokines, Inflammation, and Depression, posted by moviemom on March 18, 2008, at 9:51:51
I take 2 aspirin a couple of times a day and adjust the Borage oil as needed.. I usually take a 1000 mg in the morning and maybe one later, if I feel I need it.
Omega 3's and Sesamin are great also for inflammation. Unfortuantely sesamin lowers sex drive in men ( don't know abt women) ( I read that its something called a PPAR alpha antagonist which has the unfortunate side effect of lowering testosterone) - at least thats what I read on some bodybuilding threads.
Posted by moviemom on March 24, 2008, at 10:31:40
In reply to Re: Cytokines, Inflammation, and Depression » moviemom, posted by Jimmyboy on March 23, 2008, at 22:12:39
Thanks for the information. I'll give aspirin and borage oil a try.
Posted by Phillipa on March 24, 2008, at 18:10:56
In reply to Re: Cytokines, Inflammation, and Depression, posted by moviemom on March 24, 2008, at 10:31:40
Reminds me of one baby aspirin a day for older folks for heart disease. Just don't take too much as bleeding a risk and ear ringing. Good luck Phillipa
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