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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by tapmonk on January 29, 2008, at 11:01:26
I've read that Nardil is so effective with Social Anxiety because it effects GABA. First of all, is that true?
Assuming it is true, the next bit of info I read was that due to a short half-life of Nardil or the short time frame in which Nardil acts on GABA, that it is best for Social Anxiety to space the doses out as much as possible to ensure that Nardil is effecting GABA throughout the day. Can anyone confirm that?
Finally, for those taking Nardil (or who have taken it in the past) how did you divide your dose and what times of day did you take your pills?
thanks!
Posted by Phoenix1 on January 29, 2008, at 13:40:31
In reply to Nardil - Dosage timing for Social Anxiety, posted by tapmonk on January 29, 2008, at 11:01:26
> I've read that Nardil is so effective with Social Anxiety because it effects GABA. First of all, is that true?
>
> Assuming it is true, the next bit of info I read was that due to a short half-life of Nardil or the short time frame in which Nardil acts on GABA, that it is best for Social Anxiety to space the doses out as much as possible to ensure that Nardil is effecting GABA throughout the day. Can anyone confirm that?
>
> Finally, for those taking Nardil (or who have taken it in the past) how did you divide your dose and what times of day did you take your pills?
>
> thanks!I was just talking with tecknohead about dose spacing on another thread. What dose are you on? Right now, I am on 75mg and only take it twice a day. I am going to increase to 90mg this week and plan to take 30 mg three times a day (6am, 11am, 4pm). I'm doing this to maximize the benefits of the shorter half life, but also trying to make sure I don't take it too close to bed, as it causes insomnia for me. Anyways, I most need the anti-anxiety effects during my work day, and early evening.
Hope this helps.
Phoenix
Posted by Justherself54 on January 29, 2008, at 16:20:49
In reply to Re: Nardil - Dosage timing for Social Anxiety » tapmonk, posted by Phoenix1 on January 29, 2008, at 13:40:31
I've just increased to 60 mg. I take 30 mg in the morning, 15 around noon and try to get the last one in before 5. Although right now it doesn't seem to matter when I take it, I either sleep or I wake up all through the night..dang it..
Posted by Jedi on January 31, 2008, at 1:02:58
In reply to Nardil - Dosage timing for Social Anxiety, posted by tapmonk on January 29, 2008, at 11:01:26
Hi,
I've been on Nardil for most of the past eleven years. I have tried all kinds of spacing of the medication, and it doesn't seem to make any difference in my case. I'm on 90mg and I've tried three times daily, all 90mg at once, currently I take 45mg in the morning and 45mg at night.I take 2mg of clonazepam to enhance the GABA effect of the Nardil. I find the these two meds together really help with my social anxiety.
Be Well,
Jedi
Posted by tapiocamonk on February 1, 2008, at 17:23:45
In reply to Re: Nardil - Dosage timing for Social Anxiety » tapmonk, posted by Jedi on January 31, 2008, at 1:02:58
I've read that GABA is what makes Nardil so effective for social anxiety and that the half-life of Nardil to work on Gaba is relatively short. Wouldn't it be best then to space out the Nardil doses as much as possible, taking 3 or more doses a day?
thanks
Posted by Phoenix1 on February 1, 2008, at 19:01:31
In reply to Re: Nardil - Dosage timing for Social Anxiety » Jedi, posted by tapiocamonk on February 1, 2008, at 17:23:45
> I've read that GABA is what makes Nardil so effective for social anxiety and that the half-life of Nardil to work on Gaba is relatively short. Wouldn't it be best then to space out the Nardil doses as much as possible, taking 3 or more doses a day?
>
> thanksYou know, at higher dosages, like 60, 75mg, I find that if I take it twice a day it reduces my anxiety all day. I don't feel any peaks or valleys in my anxiety, it is always much lower than before Nardil. Now that I'm up to 90mg, I'll continue taking it twice a day for convenience. More than often than that just doesn't seem to make any difference.
Phoenix
Posted by Jedi on February 1, 2008, at 23:14:30
In reply to Re: Nardil - Dosage timing for Social Anxiety » Jedi, posted by tapiocamonk on February 1, 2008, at 17:23:45
> I've read that GABA is what makes Nardil so effective for social anxiety and that the half-life of Nardil to work on Gaba is relatively short. Wouldn't it be best then to space out the Nardil doses as much as possible, taking 3 or more doses a day?
>
> thanksHi,
I haven't done any research on the half-life of the affect of Nardil on GABAergic neurons. Just from my own experience, in my case study of one, the frequency of dosing doesn't seem to make a difference in my social anxiety. However, I'm taking a rather large dose of meds that affect GABA; 90mg Nardil & 2mg clonazepam. In your case the frequency of dosing could make a difference.
Take care,
Jedi
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