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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Jimmyboy on December 23, 2007, at 0:23:38
Can anyone explain to me the relationship between the 5ht2 receptors and SSRI induced sexual dysfunction? I know that 5ht2 antagonists can be helpful, but thats all I really know, I don't know why..
If anyone could explain this to me I would appreciate it
JB
Posted by Mikez on December 23, 2007, at 4:05:53
In reply to SSRI sex dysfunction - 5ht2a receptors - explain?, posted by Jimmyboy on December 23, 2007, at 0:23:38
From the research ive done, I have found that if it lacks the 5ht2a binding compare to other drugs, this may affect dopamine levels..no 5ht2a binding may not decrease dopamine levels like other drugs with 5ht2a binding. I have just began to research this so I could be off in my reasoning but the studies ive found support this theory.
Posted by Jimmyboy on December 23, 2007, at 12:29:04
In reply to Re: SSRI sex dysfunction - 5ht2a receptors - expla, posted by Mikez on December 23, 2007, at 4:05:53
Here is a good link talking about this subject
http://findarticles.com/p/articles/mi_qa3804/is_200207/ai_n9114293/pg_1
Posted by cumulative on December 25, 2007, at 14:58:16
In reply to SSRI sex dysfunction - 5ht2a receptors - explain?, posted by Jimmyboy on December 23, 2007, at 0:23:38
5ht2a stimulation = dopamine antagonism
It's just a basically antagonistic relationship between the two neurotransmitter systems, although there are exceptions and with many SSRIs dopamine will be potentiated in certain parts of the brain.
Now, the definite involvement of dopamine and dopaminergics in hedonia, the pleasure response, goal-directed behavior (like sex) we all know and love, eh?
Posted by Jimmyboy on December 26, 2007, at 17:00:15
In reply to Re: SSRI sex dysfunction - 5ht2a receptors - expla, posted by cumulative on December 25, 2007, at 14:58:16
Cool, thanks for the info, I did not know that.
JB
Posted by linkadge on December 28, 2007, at 23:04:20
In reply to Re: SSRI sex dysfunction - 5ht2a receptors - expla, posted by Jimmyboy on December 26, 2007, at 17:00:15
I don't think it is completely mediated by reduction in CNS dopaminergic neurotransmission. I remember reading about some involvement of the 5-ht2c receptors (in the lower brainstem or something) controling ejaculatory threshold or something.
The SSRI's affect both the desire, and the capacity. Ie you can take a drug like amphetamine, caffiene, etc and regain some of the desire yet still have genital anesthesia or anorgasmia etc.
There are other possible causes too like perhaps the SSRI's lowering growth hormone via 5-ht1d receptor desensitzation etc. Acetylcholine is also involved in certain phases of sexual responce/desire, so indirect anticholinergic effects might be involved.
Linkadge
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