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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 17 of 17. This is the beginning of the thread.
Posted by pdg1234567 on December 10, 2007, at 20:06:48
Which ADS are weight neutrel?
Posted by Racer on December 10, 2007, at 20:27:11
In reply to Weight - Neutrel ADs?, posted by pdg1234567 on December 10, 2007, at 20:06:48
Your mileage will almost certainly vary. Some people gain weight on medications that lead to weight loss for others. Also, weight gain can vary by dosage -- higher doses of some medications will cause weight gain, while lower doses of others can cause more weight gain than the higher doses.
In general, though, Wellbutrin is weight neutral, higher doses of Remeron are said to lead to less weight gain than lower doses, Zoloft is generally pretty weight neutral, desipramine is supposed to cause less weight gain than other TCAs. EMSAM is supposed to be weight neutral. Serazone isn't known for weight gain.
That's what I can think of...
Just remember -- some people don't gain weight on any of them. Mileage varies. The only prediction of whether you're likely to gain weight on any medication is whether you've gained weight on a similar drug in the past.
Hope that helps.
Posted by Netch on December 11, 2007, at 4:09:10
In reply to Weight - Neutrel ADs?, posted by pdg1234567 on December 10, 2007, at 20:07:09
Usually all SSRI are weight neutral.
Posted by Justherself54 on December 11, 2007, at 10:50:46
In reply to Re: Weight - Neutrel ADs?, posted by Netch on December 11, 2007, at 4:09:10
> Usually all SSRI are weight neutral.
>Sorry, I have to disagree..some people are lucky and don't gain weight..but there are lots who gain..I'm one of them, between Zoloft and Lexapro 80 pounds worth..I've never weighed so much in my whole life..
Posted by rskontos on December 11, 2007, at 13:11:14
In reply to Re: Weight - Neutrel ADs?, posted by Justherself54 on December 11, 2007, at 10:50:46
SSRI's can make you crave sugar I can't give you the science behind it but you can research it. I have been on two and both did it. It is insidious too. YOu don't know or realize it as it creeps up on you. I was at an ideal weight for me too when I went on lexapro this last time. I had lost all the weight I had gain on cymbalta.
As much as depression is hard enough, I am sorry weight gain, is unacceptable for me. The biggest issue for me is I didn't want to eat anything but sugar. No veggies, no fruit, I wanted HARD candy. It was HARD to stop even after I stopped the lex. So I don't think SSRI's are neutral and besides the information collected from the manufacturers stopped after 12 weeks. How would they know what the additional side effects are unless they continue to monitor it and why would and why would they let out that weight gain is a side effect that is definitely one they would hide. We aren't exactly a skinny nation. There are a lot of people here that have had weight gain from AD's. And for me lex nor cymbalta did what I needed from either to justify the weight gain. I felt worse in both cases. Too flat. rk
Posted by Racer on December 11, 2007, at 13:16:02
In reply to Re: Weight - Neutrel ADs?, posted by rskontos on December 11, 2007, at 13:11:14
Longer term studies have shown that, for many people, SSRIs cause initial weight loss, followed by weight gain starting around four to six months into treatment.
The problem isn't related to changes to eating habits, so much as changes to metabolism. Serotonin is primarily a gut-related neurotransmitter -- various receptor types influence hunger/satiety signalling, as well as bowel motility and other digestive processes. Only about 5% of the serotonin in our bodies is active in the central nervous system or brain, the rest is working on your gut.
Posted by Phillipa on December 11, 2007, at 15:48:02
In reply to Re: Weight - Neutrel ADs?, posted by Racer on December 11, 2007, at 13:16:02
Luvox hasn't caused weight gain it's the truffle eating at night. Phillipa low dose luvox remember no taste and smell and the texture of the truffles is better than nothing.
Posted by pdg1234567 on December 11, 2007, at 19:21:19
In reply to Re: Weight - Neutrel ADs?, posted by Phillipa on December 11, 2007, at 15:48:02
THanks for the info so sounds like SSRI cause weight gain for some/majoirty. What about MAOIs, TCAs, SRNI, other? - so what would not cause weight gain?
Posted by linkadge on December 11, 2007, at 20:45:57
In reply to Re: Weight - Neutrel ADs?, posted by pdg1234567 on December 11, 2007, at 19:21:19
If SSRI's help the most, you could try agumenting with wellbutrin. Venlafaxine may cause less weight gain than SSRI's.
Linkadge
Posted by curiousone on December 12, 2007, at 20:02:53
In reply to Re: Weight - Neutrel ADs?, posted by Netch on December 11, 2007, at 4:09:10
I was on Effexor and also gained weight - 15 pounds in just one year. It didn't get bad until I was on my second year of taking the medication.
Posted by rskontos on December 13, 2007, at 10:11:23
In reply to Re: Weight - Neutrel ADs?, posted by Racer on December 11, 2007, at 13:16:02
Racer, do the studies show how to offset the change in metabolic rate. And if when you remove the SSRI is the metabolic rate returns . I always thought that once it was changed, metabolic rate was hard to change again.
Anyone know. thanks
rk
Posted by Racer on December 13, 2007, at 10:47:49
In reply to Re: Weight - Neutrel ADs? » Racer, posted by rskontos on December 13, 2007, at 10:11:23
As far as I know, your metabolic rate should return to baseline after you stop SRIs -- I know that's been the case for me. Controlling it while on the drugs is a little harder. There are medications that may help, so it's worth talking to a good psychopharmacologist, but the one that had the best potential has been removed from the market. (That was Zelnorm.)
Best bet is to talk to your doctor about it. If your doctor is one of those who still thinks SSRIs cause weight LOSS over the longer term, maybe run a search at PubMed to take in some abstracts. Medscape or PubMed are great resources for information on weight gain from antidepressants.
Hope that helps.
Posted by jms600 on December 13, 2007, at 15:58:28
In reply to Weight - Neutrel ADs?, posted by pdg1234567 on December 10, 2007, at 20:07:09
I have taken a number of SSRIs - for me Seroxat caused the most weight gain I put well over a stone on while taking this drug!
Out of the SSRIs I have taken, I found that Prozac didn't cause any weight gain at all (I actually lost weight on Prozac as I just didn't get the cravings).
I guess - as with all antidepressants - that it's all about how your body reacts to the drug. What works for one may not work for another, and vice versa.
Good luck!
Posted by pdg1234567 on December 13, 2007, at 18:32:09
In reply to Re: Weight - Neutrel ADs? » rskontos, posted by Racer on December 13, 2007, at 10:47:49
Thanks all for the advise.
Posted by linkadge on December 13, 2007, at 22:30:52
In reply to Re: Weight - Neutrel ADs?, posted by pdg1234567 on December 13, 2007, at 18:32:09
Some of the SSRI's can alter blood sugar levels. I remember reading a mouse study suggesting that sertraline was somewhat diabetogenic, esp in higher doses.
Linkadge
Posted by pdg1234567 on December 14, 2007, at 6:54:15
In reply to Mileage varies -- A LOT! » pdg1234567, posted by Racer on December 10, 2007, at 20:27:11
Racer - thanks that helps
Your mileage will almost certainly vary. Some people gain weight on medications that lead to weight loss for others. Also, weight gain can vary by dosage -- higher doses of some medications will cause weight gain, while lower doses of others can cause more weight gain than the higher doses.
>
> In general, though, Wellbutrin is weight neutral, higher doses of Remeron are said to lead to less weight gain than lower doses, Zoloft is generally pretty weight neutral, desipramine is supposed to cause less weight gain than other TCAs. EMSAM is supposed to be weight neutral. Serazone isn't known for weight gain.
>
> That's what I can think of...
>
> Just remember -- some people don't gain weight on any of them. Mileage varies. The only prediction of whether you're likely to gain weight on any medication is whether you've gained weight on a similar drug in the past.
>
> Hope that helps.
Posted by Dove on December 18, 2007, at 10:27:42
In reply to Re: Mileage varies -- A LOT! » Racer, posted by pdg1234567 on December 14, 2007, at 6:54:15
Of the SSRI's, Prozac has been the most weight neutral for me, even enabling me to resist sweets. Venlafaxine (Effexor) unaugmented was not weight neutral for me, and did indeed cause severe carb cravings. Low dose Remeron (Mirtazapine) was really really bad for me.
Adding 5mgs of Adderall in the morning and 10-20 mgs of Prozac to the Effexor/Remeron combo did help significantly with the cravings. Serzone did not seem to cause weight gain for me, but it also did not do the job I needed it to do. Wellbutrin was an unpleasant experience but did not cause weight gain or cravings, but I did not stay on Wellbutrin for more than 3 months, so not sure what it does long-term.
Prozac is my long-term SSRI of choice partly due to it's weight neutrality.
This is the end of the thread.
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