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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by falconman on April 19, 2007, at 13:27:50
Hi,
I here that a combination of nardil and selegiline would be fatal. Is this correct, and can anyone explain why if it is correct? It would be a real shame if they could not be taken together. I'd imagine they would be a very potent combination that would have the balance of sedation and activation. If this combination is not safe, what can you add to nardil to increase its effects? I'm especially interested in the combination of nardil + a dopaminergic drug eg. DLPA, selegiline, low dose amisulpride, ritalin(concerta), Phenylathymine..ect. also is it safe to take rhodiola rosea and DHEA whilst taking nardil? What about protein powders that contain phenylalanine?
Thanks
Thanks
Posted by falconman on April 19, 2007, at 13:31:57
In reply to nardil/ selegiline, posted by falconman on April 19, 2007, at 13:27:50
Also is nardil + nootropics like piracetam or Vinpocetine a safe combination?
Thanks
Posted by UgottaHaveHope on April 21, 2007, at 3:05:10
In reply to Re: nardil/ selegiline, posted by falconman on April 19, 2007, at 13:31:57
Find one of his posts and Babblemail him.
Posted by psychobot5000 on April 23, 2007, at 22:25:53
In reply to nardil/ selegiline, posted by falconman on April 19, 2007, at 13:27:50
> Hi,
> I here that a combination of nardil and selegiline would be fatal. Is this correct, and can anyone explain why if it is correct?I think in would be more accurate to say 'potentially' fatal. I think the theory is that taking more than one MAO inhibitor at a time means (over)flooding your system with certain neurochemicals, who can't be metabolised worth a damn. I believe (but don't quote me) that serotonin syndrome is one of the paths that can take to death. MAO inhibitors are somewhat unpredictable medications, anyway, without combining two. But besides the danger, it seems to me that it might just be redundant to pile two MAOis on top of one another.
>It would be a real shame if they could not be >taken together.
Agreed. It'd be great to know what would happen, were it workable.
> I'd imagine they would be a very potent >combination that would have the balance of >sedation and activation.
I never personally got any activation out of selegiline--I'm not sure it's very consistent in that regard. But maybe you know from experience...
>If this combination is not safe, what can you add >to nardil to increase its effects? I'm especially >interested in the combination of nardil + a >dopaminergic drug...
Well, keep in mind that nardil is pretty dopaminergic in the first place. But switching to tranylcypromine/parnate from nardil would add additional, stimulant-like dopaminergic mechanisms. I think docs would be much more likely to prescribe it, than to give you an additional dopaminergic med with Nardil. Just a thought--such a crapshoot to switch your basic med like that...
But anyway, I have a few suggestions for you.
Specialists in MAO inhibitors do sometimes prescribe stimulants (dexamphetamine/dexedrine, methylphenidate/ritalin/concerta, etc) for added effect, but it's not a widely accepted practice. The same applies for augmenting them with tricyclics--PDR and prescribing instructions say not to. In any case, you have to start low, and go slow, monitoring your blood pressure and heart-rate daily, all the while. A more doctor-favored alternative is Provigil, as it's considered much safer for the heart, and many more docs are comfortable with adding it to an MAOi. I think some of the posters here have found it useful for countering MAOi drowsiness or sedation.
> DLPA, selegiline, low dose amisulpride, ritalin(concerta), Phenylathymine..ect. also is it safe to take rhodiola rosea and DHEA whilst taking nardil? What about protein powders that contain >phenylalanine?I think DHEA ought to be perfectly safe...might want to be more careful about DLPA and such. Protein powders are generally considered a no-no, because they can cause blood-pressure crises. As for Rhodiola...I couldn't tell you. I don't think there's much clinical experience combining the it with MAOis, though, because it's so uncommonly used in classical medicine. It does increase monoamine supplies, so theoretically there would be a risk.
I don't see why amisulpride would be unsafe...if you're looking for more dopamine, you might try fish oil also. Perhaps caffeine in moderation might be useful.
MAOi-specializing docs sometimes seem comfortable with combining them with tricyclics, so for an activating effect, you might try desipramine or nortriptyline--though they're considered more noradrenergic than dopaminergic.
Best of luck (be careful)!
Psychbot
Posted by falconman on April 24, 2007, at 3:43:59
In reply to Re: nardil/ selegiline » falconman, posted by psychobot5000 on April 23, 2007, at 22:25:53
This is the end of the thread.
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