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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by Crazy Horse on March 20, 2007, at 11:29:04
I just switched from generic Parnate (Tranylcypromine) to brand name Parnate because i didn't think the generic was working as well as genuine Parnate. I wonder if it was my imagination (i don't think it was) or if the generic was really inferior to the brand name?
-Monte
Posted by Phillipa on March 20, 2007, at 11:47:53
In reply to Generic Parnate, posted by Crazy Horse on March 20, 2007, at 11:29:04
Well I know it's not my imagination with xanax. I have lived it. No don't listen there is 20% difference either way your batch was on the low end probably. I know the real one will work. Love Phillipa
Posted by Quintal on March 20, 2007, at 12:32:15
In reply to Generic Parnate, posted by Crazy Horse on March 20, 2007, at 11:29:04
It's possible you don't get the most out of the particular formulation of the generic brand you were using, but all tablets that contain 10mg tranylcypromine are genuine and real medicines. My psychiatric nurse once asked a pharmacology professor if he believed there was a difference between brands, and he said in his own personal opinion there was a potential for different effects due to the different binders, colorants and fillers used. They can affect rates of absorption and the site in the gut where most of the drug is absorbed, and that can make a difference to the overall effect of the drug.
You might then assume that generics are inferior and the most reliable response is to the brand name drug, but that isn't the case. My psychiatric nurse had many patients who only responded to one particular make, and it wasn't the brand name Prozac, it was generic Dr. Reddy's fluoxetine that was often most effective. Some generic manufacturers by either accident or design produce medicines superior to the brand name manufacturers.
Q
Posted by naughtypuppy on March 20, 2007, at 14:59:13
In reply to Re: Generic Parnate » Crazy Horse, posted by Quintal on March 20, 2007, at 12:32:15
Aren't generics required to prove an equivelent bioavialability as the patent meds or is it just because it is difficult if not impossible to measure blood serum levels?
Posted by halcyondaze on March 20, 2007, at 16:46:52
In reply to Re: Generic Parnate » Quintal, posted by naughtypuppy on March 20, 2007, at 14:59:13
Please let me know what your experience is with generic v. brand because I have yet to get generic Parnate and I am wondering if it is worth the extra $40 per month to stay on brand name.
Posted by Crazy Horse on March 20, 2007, at 18:42:58
In reply to Re: Generic Parnate, posted by halcyondaze on March 20, 2007, at 16:46:52
> Please let me know what your experience is with generic v. brand because I have yet to get generic Parnate and I am wondering if it is worth the extra $40 per month to stay on brand name.
I will in about a week,Okay? Please remind me.
-Monte
Posted by willyee on March 21, 2007, at 9:48:34
In reply to Generic Parnate, posted by Crazy Horse on March 20, 2007, at 11:29:04
> I just switched from generic Parnate (Tranylcypromine) to brand name Parnate because i didn't think the generic was working as well as genuine Parnate. I wonder if it was my imagination (i don't think it was) or if the generic was really inferior to the brand name?
>
> -Monte
Believe the longer you are on it,the more suspectable you will be to very minor differances,
Ive tried about 4 versions,and i save or would 13 on generic,ive now choosen to stay on brand and pay,however generic was totaly that bad at all.Funny though cause i cant stand pzifer nuerontion,it actualy interacts w parnate makes me sweat,its a slimy enectric type coating,HOWEVER the powdery generic version has zero interaction on my case,and it works very well,go figure.
Id recomend simply staying on brand.
Posted by tessellated on March 21, 2007, at 19:39:02
In reply to Re: Generic Parnate, posted by willyee on March 21, 2007, at 9:48:34
i think the metabolic variation is highly idiosynchratic and variable with any MAOI.
fatty intake, would likely slow/speed up ingestion as much as binders-no?
i often chew my acetominphen, provigil, etc for a faster release; which is not always desired.
i do not think the generic vs. namebrand parnate create as much of a significant difference as my diet.
Posted by halcyondaze on March 22, 2007, at 16:42:27
In reply to Re: Generic Parnate, posted by tessellated on March 21, 2007, at 19:39:02
Parnate is just such a ... fickle drug as it is that I don't know if I want to mess with a good thing by going generic.
Posted by Crazy Horse on March 22, 2007, at 18:27:09
In reply to Re: Generic Parnate, posted by halcyondaze on March 22, 2007, at 16:42:27
> Parnate is just such a ... fickle drug as it is that I don't know if I want to mess with a good thing by going generic.
Yes, i totally agree. You know i am feeling better with the brand name so far, but unfortunately i'm not sure if it's the brand name or the fact that my pdoc raised my dose.
-Monte
Posted by halcyondaze on March 23, 2007, at 14:23:12
In reply to Re: Generic Parnate » halcyondaze, posted by Crazy Horse on March 22, 2007, at 18:27:09
> > Parnate is just such a ... fickle drug as it is that I don't know if I want to mess with a good thing by going generic.
>
> Yes, i totally agree. You know i am feeling better with the brand name so far, but unfortunately i'm not sure if it's the brand name or the fact that my pdoc raised my dose.
>
> -Montewhat's your dose?
I'm on 120 per day.
I usually divide it into 3 pills four times a day or 4 pills 3 times a day.
Posted by Crazy Horse on March 23, 2007, at 18:54:31
In reply to Re: Generic Parnate, posted by halcyondaze on March 23, 2007, at 14:23:12
> > > Parnate is just such a ... fickle drug as it is that I don't know if I want to mess with a good thing by going generic.
> >
> > Yes, i totally agree. You know i am feeling better with the brand name so far, but unfortunately i'm not sure if it's the brand name or the fact that my pdoc raised my dose.
> >
> > -Monte
>
> what's your dose?
>
> I'm on 120 per day.
>
> I usually divide it into 3 pills four times a day or 4 pills 3 times a day.I'm also on 120. I take 7 in the morning and 5 at noon. The most amaziing thing to me is that i don't have insomnia. The problem i'm having is that i feel pretty tired most of the time..any ideas?
-Monte
Posted by halcyondaze on March 23, 2007, at 20:41:45
In reply to Re: Generic Parnate » halcyondaze, posted by Crazy Horse on March 23, 2007, at 18:54:31
> > > > Parnate is just such a ... fickle drug as it is that I don't know if I want to mess with a good thing by going generic.
> > >
> > > Yes, i totally agree. You know i am feeling better with the brand name so far, but unfortunately i'm not sure if it's the brand name or the fact that my pdoc raised my dose.
> > >
> > > -Monte
> >
> > what's your dose?
> >
> > I'm on 120 per day.
> >
> > I usually divide it into 3 pills four times a day or 4 pills 3 times a day.
>
> I'm also on 120. I take 7 in the morning and 5 at noon. The most amaziing thing to me is that i don't have insomnia. The problem i'm having is that i feel pretty tired most of the time..any ideas?
>
> -Montehave you considered spreading it out more throughout the day so you don't "crash"? Or what about adding a stimulant like Dexedrine?
Posted by Crazy Horse on March 24, 2007, at 16:20:58
In reply to Re: Generic Parnate, posted by halcyondaze on March 23, 2007, at 20:41:45
> > > > > Parnate is just such a ... fickle drug as it is that I don't know if I want to mess with a good thing by going generic.
> > > >
> > > > Yes, i totally agree. You know i am feeling better with the brand name so far, but unfortunately i'm not sure if it's the brand name or the fact that my pdoc raised my dose.
> > > >
> > > > -Monte
> > >
> > > what's your dose?
> > >
> > > I'm on 120 per day.
> > >
> > > I usually divide it into 3 pills four times a day or 4 pills 3 times a day.
> >
> > I'm also on 120. I take 7 in the morning and 5 at noon. The most amaziing thing to me is that i don't have insomnia. The problem i'm having is that i feel pretty tired most of the time..any ideas?
> >
> > -Monte
>
> have you considered spreading it out more throughout the day so you don't "crash"? Or what about adding a stimulant like Dexedrine?
>
> Both excellent ideas. I think i'm going to try 4 pills 3 times a day tomorrow. Thanks.-Monte
Posted by halcyondaze on March 27, 2007, at 16:55:04
In reply to Re: Generic Parnate, posted by Crazy Horse on March 24, 2007, at 16:20:58
> > > > > > Parnate is just such a ... fickle drug as it is that I don't know if I want to mess with a good thing by going generic.
> > > > >
> > > > > Yes, i totally agree. You know i am feeling better with the brand name so far, but unfortunately i'm not sure if it's the brand name or the fact that my pdoc raised my dose.
> > > > >
> > > > > -Monte
> > > >
> > > > what's your dose?
> > > >
> > > > I'm on 120 per day.
> > > >
> > > > I usually divide it into 3 pills four times a day or 4 pills 3 times a day.
> > >
> > > I'm also on 120. I take 7 in the morning and 5 at noon. The most amaziing thing to me is that i don't have insomnia. The problem i'm having is that i feel pretty tired most of the time..any ideas?
> > >
> > > -Monte
> >
> > have you considered spreading it out more throughout the day so you don't "crash"? Or what about adding a stimulant like Dexedrine?
> >
> > Both excellent ideas. I think i'm going to try 4 pills 3 times a day tomorrow. Thanks.
>
> -Monte
>
>Did it help?
Posted by Crazy Horse on March 27, 2007, at 19:10:00
In reply to Re: Generic Parnate, posted by halcyondaze on March 27, 2007, at 16:55:04
> > > > > > > Parnate is just such a ... fickle drug as it is that I don't know if I want to mess with a good thing by going generic.
> > > > > >
> > > > > > Yes, i totally agree. You know i am feeling better with the brand name so far, but unfortunately i'm not sure if it's the brand name or the fact that my pdoc raised my dose.
> > > > > >
> > > > > > -Monte
> > > > >
> > > > > what's your dose?
> > > > >
> > > > > I'm on 120 per day.
> > > > >
> > > > > I usually divide it into 3 pills four times a day or 4 pills 3 times a day.
> > > >
> > > > I'm also on 120. I take 7 in the morning and 5 at noon. The most amaziing thing to me is that i don't have insomnia. The problem i'm having is that i feel pretty tired most of the time..any ideas?
> > > >
> > > > -Monte
> > >
> > > have you considered spreading it out more throughout the day so you don't "crash"? Or what about adding a stimulant like Dexedrine?
> > >
> > > Both excellent ideas. I think i'm going to try 4 pills 3 times a day tomorrow. Thanks.
> >
> > -Monte
> >
> >
>
>
>
> Did it help?
>No it didn't. I feel like sh*t...i take a dose i.e. 30-40mgs, and i feel good for about two hours than i just crash. I've even tried taking 20 every 2 hours and i still feel like crap. I'm seriously thinking about tapering off and giving Remeron a shot, it worked very well for me for about 4 years until it pooped out..but it's been 2 years ago so maybe it'll work now.
I now have absolutely no energy on Parnate..it's strange??
-Monte
This is the end of the thread.
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