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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by River1924 on February 7, 2007, at 0:04:22
Patients with depression are subject to neuropsychological deficits in attention, memory, psychomotor speed, processing speed, and executive function. When they are treated, they perform better, but they do not perform as well as normal controls.
They improve, at least to a degree, but do not "normalize." The data reported here suggest that how well they perform on neurocognitive testing may be a function of the antidepressant with which they are treated. What our data show is that depressed patients on bupropion perform as well as normals do on a battery of neurocognitive tests. Patients on venlafaxine and SSRIs do not.
These results are consistent with the hypothesis that cognitive benefit may occur relative to an antidepressant's norepinephrine activity, while lack of benefit may relate to its serotonergic activity. The noradrenergic/dopaminergic antidepressant bupropion is associated with normal function. The mixed serotonin/norepinephrine reuptake venlafaxine performs less well than bupropion but better than the SSRIs (Figure). This is consistent with the principle that enhanced norepinephrine metabolism is associated with better cognitive performance of a variety of neurocognitive tasks
Posted by Phillipa on February 7, 2007, at 11:51:17
In reply to Wellbutrin and brain power..., posted by River1924 on February 7, 2007, at 0:04:22
River how come in one week I was appearing manic to my pdoc and he hospitalized me on l50mg of wellbutrin? I thought it was for manic conditions? Confused again. Love Phillipa
Posted by River1924 on February 7, 2007, at 13:03:54
In reply to Re: Wellbutrin and brain power... » River1924, posted by Phillipa on February 7, 2007, at 11:51:17
I think this applied to people with major depression only. Or put another way, all anti-depressants can induce some kind of mania (anxiousness, irritability, euphoria) in those prone to mood swings. Since you are prone to them, I would assume you were started at the lowest dose possible and/or were on something to prevent a manic upswing in the first place. River.
Posted by chante on February 9, 2007, at 18:06:06
In reply to Re: Wellbutrin and brain power..., posted by River1924 on February 7, 2007, at 13:03:54
I'm glad to hear that , it answer my question of today... so now I know not to worry for my classes I will do fine . lol
Posted by iforgotmypassword on February 12, 2007, at 8:12:54
In reply to Re: Wellbutrin and brain power... » River1924, posted by Phillipa on February 7, 2007, at 11:51:17
wierd, maybe it is lyme. my doctor gave me drama over wellbutrin, but prolly due to my being male, i was not hospitalized (yay.)
Posted by River1924 on February 12, 2007, at 16:34:36
In reply to Wellbutrin and brain power..., posted by River1924 on February 7, 2007, at 0:04:22
Well it seemed important to me. As it states, most people in remission don't recover their cognitive abilities. Doesn't anyone think that is important?
Gawd... for me the cognitive parts of depression are the most impossible... they make me semi-functional at my best. I could feel suicidal and do and create. It is hard when I can't think.
This is the end of the thread.
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