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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by liliths on January 14, 2007, at 13:22:17
hi all,
has anybody heard anything about this drug?
"New River Pharmaceuticals and Shire Receive Approvable Letter for VYVANSE™ (lisdexamfetamine dimesylate) for the Treatment of ADHD"
is this available in the US yet?
anybody try it?thanks
namaste,
lilith
Posted by Quintal on January 14, 2007, at 19:15:10
In reply to VYVANSE™ ??, posted by liliths on January 14, 2007, at 13:22:17
Sounds interesting Liliths, L-lysine bound dexamphetamine. So they claim it has less abuse potential than pure amphetamine, (so therefore a wider potential market for adult ADHD and possibly other disorders like depression etc)?
Q
Posted by med_empowered on January 14, 2007, at 20:12:09
In reply to Re: VYVANSE™ ?? » liliths, posted by Quintal on January 14, 2007, at 19:15:10
but..its been approved as a schedule II? I dont get it. Can they get it put in schedule III post-approval? B/c it seems to me that if they're going to charge extra $$$ for such an old drug (and dexedrine is old as the hills) they should at least offer some kind of advantage, like having a drug that docs can call in and patients can refill.
Posted by Tom Twilight on January 15, 2007, at 2:12:30
In reply to Re: VYVANSE™ ??, posted by med_empowered on January 14, 2007, at 20:12:09
It sounds like an interesting drug
It might be smoother than normal stims & less abuse potential, so maybe a bit less control?
Still cause insomnia and have all the neurotoxic potential of other stims I suppose.
Doubt it will ever be released in the UK anyway :(
Posted by liliths on January 15, 2007, at 7:42:29
In reply to Re: VYVANSE™ ?? » liliths, posted by Quintal on January 14, 2007, at 19:15:10
hi Q
sounds like we don't have anyone on it yet
I thought it sounded interesting as well... supposedly the company has 3 different ADHD meds in progress... though this was the only one that 'appeared' to be finished and approved. I just can't tell how available it actually is yet
I hope we get some posts from people who are using it
namaste,
lilith> Sounds interesting Liliths, L-lysine bound dexamphetamine. So they claim it has less abuse potential than pure amphetamine, (so therefore a wider potential market for adult ADHD and possibly other disorders like depression etc)?
>
> Q
Posted by notfred on January 15, 2007, at 14:21:50
In reply to Re: VYVANSE™ ??, posted by med_empowered on January 14, 2007, at 20:12:09
> but..its been approved as a schedule II? I dont get it.
all amphetamines are sch II.http://www.nrpharma.com/products/vyvanse.htm
"Vyvanse is a conditionally bioreversible derivative (CBD) of amphetamine'
Posted by laima on January 15, 2007, at 16:04:35
In reply to Re: VYVANSE™ ?? » liliths, posted by Quintal on January 14, 2007, at 19:15:10
So is the big development with this drug basically that it has less abuse potential than regular dexamphetamine? (That's the generic for dexedrine, isn't it?) How do they figure it's less abuseable? I wonder if that means they cut out the mood boosting part. Or hard to say?
Posted by Quintal on January 15, 2007, at 16:45:18
In reply to Re: VYVANSE™ ??, posted by laima on January 15, 2007, at 16:04:35
It seems that Vyvanse is released slowly and is therefore less euphoric than standard amphetamine.
__________________________________________________
New River Pharmaceuticals Inc. (NASDAQ: NRPH) designed lisdexamfetamine dimesylate as an inactive prodrug in which d-amphetamine is bonded to l-lysine, a naturally occurring amino acid. Lisdexamfetamine dimesylate remains inactive until converted and active d-amphetamine is gradually released.
In this single blind, placebo- and active-controlled, single-dose escalation study, lisdexamfetamine dimesylate tended to be less euphoric than d-amphetamine sulfate 40 mg, and had a later peak effect.
http://www.medicalnewstoday.com/medicalnews.php?newsid=46440
__________________________________________________
Q
Posted by laima on January 15, 2007, at 17:35:13
In reply to Re: VYVANSE™ ?? » laima, posted by Quintal on January 15, 2007, at 16:45:18
Oh. Less euphoric? I don't get how that's an advantage for the patient though, unless patient is having a lot of temptation to abuse, or is just too happy to being with.Thanks.
> It seems that Vyvanse is released slowly and is therefore less euphoric than standard amphetamine.
>
> __________________________________________________
>
> New River Pharmaceuticals Inc. (NASDAQ: NRPH) designed lisdexamfetamine dimesylate as an inactive prodrug in which d-amphetamine is bonded to l-lysine, a naturally occurring amino acid. Lisdexamfetamine dimesylate remains inactive until converted and active d-amphetamine is gradually released.
>
> In this single blind, placebo- and active-controlled, single-dose escalation study, lisdexamfetamine dimesylate tended to be less euphoric than d-amphetamine sulfate 40 mg, and had a later peak effect.
>
> http://www.medicalnewstoday.com/medicalnews.php?newsid=46440
> __________________________________________________
>
>
> Q
Posted by notfred on January 15, 2007, at 20:19:42
In reply to Re: VYVANSE™ ??, posted by laima on January 15, 2007, at 17:35:13
>
> Oh. Less euphoric? I don't get how that's an advantage for the patient though, unless patient is having a lot of temptation to abuse, or is just too happy to being with.
>
> Thanks.
>
One clear advantage is that it is different enough from the existing patents to qualify for a new patent.
Posted by med_empowered on January 15, 2007, at 20:32:22
In reply to Re: VYVANSE™ ??, posted by notfred on January 15, 2007, at 20:19:42
yeah but...seriously: if its in schedule II, how are there any real benefits? And, if its still in schedule II, can they really say its **that** much less abusable? All I see is added expense and no real benefit for doc or consumer, except maybe that docs can treat former substance abusers with amphetamines (**maybe**).
So..does it have to be in schedule II just b/c its an amphetamine? Wasn't there an effort a couple years ago to re-schedule Ritalin to schedule III?
Posted by notfred on January 15, 2007, at 22:44:57
In reply to Re: VYVANSE™ ??, posted by med_empowered on January 15, 2007, at 20:32:22
>
> So..does it have to be in schedule II just b/c its an amphetamine? Wasn't there an effort a couple years ago to re-schedule Ritalin to schedule III?Well Rit is not an amphetamine. Schedules 1-4
define the amount of medically sound use vs abuse potential, with 1 having no legit use and highest level of abuse potential. you can look up the exact wording that defines each schedule. it has been decided that amphetamines are all schedule II, due to their abuse potential and legit medical use. so far every known amphetamine is schedule II. The Analogue Drug Act would extend to all apmhetamines like those scheduled.I think Ritalin should remain II, under the current system.
Posted by med_empowered on January 15, 2007, at 22:57:18
In reply to Re: VYVANSE™ ??, posted by notfred on January 15, 2007, at 22:44:57
so...all forms of amphetamine, irrespective of actual abuse potential, will be in schedule II? So...even if the maker can demonstrate a reduced abuse liability, it's still stuck in schedule II?
This is the end of the thread.
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