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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by jealibeanz on September 10, 2006, at 3:42:29
Are there any new drugs in the pipeline that are likely to be approved for anxiety/depression or ADHD? Anything with completely novel mechanisms to look forward to? Aren't we all sick and tired of the same old, same old?!
Posted by Tom Twilight on September 10, 2006, at 4:43:02
In reply to What's new?, posted by jealibeanz on September 10, 2006, at 3:42:29
I've been asking the same question over the last few weeks.
No one has respondedFrom my own research I can see that there seem to be some A1-Seratonin receptor agonists and some NK1-Antagonists in the pipeline.
Its a real pity there aren't more GABA drugs or Opiates.
I'm furious that Ocinaplon was discontinued!I have admit I'm skeptical of anything really effective being aproved soon
Posted by linkadge on September 10, 2006, at 8:10:48
In reply to Re: What's new?-I'll second that!, posted by Tom Twilight on September 10, 2006, at 4:43:02
Not a whole lot. From my understanding the majority of the drugs that were in the pipelines a few years back have been discontinued for various reasons.
Certain promising drugs like valdoxan and gepirone were discontinued for lack of demonstration of efficacy, which is dumb in my opinion since these drugs were promising. Theres got to be more to the story.
Theres no way IMO that buspar be on the market but gepirone not. Gepirone is much more potent and selective. WTF.
There was a NK-1 antagonist discontinued for lack of demonstration of efficacy.
There is URB-597 which is FAAH inhibitor. It increases endogenious levels of anandamide, an endogenious marajuanna like substance. Applications being depression and anxiety.
I doubt this one will make it to the market. Its just too promising.There was a 5-ht1b autoreceptor antagonist, which in my opinion would be a very effective an fast acting depression treament.
There are so many reasons that drugs get dropped. Its sad.
Its not necessarily that these drugs with new targets are any less effective IMO, but I think that the FDA feels more comfortable approving a varient of something thats alread on the market.
Another reuptake inhibitor, eh, sure why not.
To be honest, I don't think you're going to see anything novel or worthwile for another 10 years.
Linkadge
Posted by Tom Twilight on September 10, 2006, at 12:21:15
In reply to Re: What's new?-I'll second that!, posted by linkadge on September 10, 2006, at 8:10:48
Hey Linkagde
Hopefully your take on what might be aproved is a little bleak!
I think Gepirone is still in development, it might be aproved in 2007.
It is ridicules that its taken so long, considering its been around since the 1980s!
Posted by Phillipa on September 10, 2006, at 13:05:20
In reply to Re: What's new?-I'll second that!, posted by linkadge on September 10, 2006, at 8:10:48
Too late for me. Love Phillipa
Posted by Klavot on September 10, 2006, at 14:33:37
In reply to What's new?, posted by jealibeanz on September 10, 2006, at 3:42:29
> Are there any new drugs in the pipeline that are likely to be approved for anxiety/depression or ADHD? Anything with completely novel mechanisms to look forward to? Aren't we all sick and tired of the same old, same old?!
I'm under the impression that research is being done into drugs that act on melatonin, though research is still in an embryonic phase.
Posted by Sabre on September 10, 2006, at 20:21:26
In reply to Re: What's new?-I'll second that! » linkadge, posted by Phillipa on September 10, 2006, at 13:05:20
The CRF1 and NK1 antagonists might be possibilities:
http://www.gsk.com/investors/pp_pipeline_standard.htm
http://www.astrazeneca.com/article/511390.aspx
D-Cycloserine is another.
Regards
Sabre
Posted by johnnyj on September 10, 2006, at 21:26:14
In reply to What's new?, posted by jealibeanz on September 10, 2006, at 3:42:29
Here is a list
http://www.phrma.org/files/Mental_Illness_New_Meds_report.pdf
Posted by laima on September 16, 2006, at 7:31:43
In reply to What's new?, posted by jealibeanz on September 10, 2006, at 3:42:29
If anyone feels like digging around, there are clues here, too:
This is the end of the thread.
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