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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Maxime on April 4, 2006, at 14:43:27
Hi
I am wondering what symptoms I would have if I didn't wait long enough to let the Prozac clear from my system.
I am really not feeling very well.
Maxime
Posted by Racer on April 4, 2006, at 15:29:26
In reply to What if I didn't wait long enough, posted by Maxime on April 4, 2006, at 14:43:27
Potentially severe acute adverse reaction to a serotonin agonist.
Pathophysiology* excessive stimulation of 5-HT1A and possibly 5-HT2 receptors
* usually result of administration of serotonin agonist to patient who is already receiving a drug capable of potentiating effects of serotoninergic pathways
* may also occur as a result of:
o enhanced serotonin release (eg by cocaine or "ecstasy")
o decreased serotonin re-uptake (eg tricyclic antidepressants)
o decreased serotonin metabolism (eg monoamine oxidase inhibitors)
o excessive adminstration of serotonin precursors or agonists (trazodone, L-tryptophan)Clinical features
Characterized by cognitive and behavioural changes, autonomic dysfunction and neuromuscular abnormalities. Usually develops within hours of administration of precipitating agent.
Cognitive & behavioural changes* confusion
* agitation
* comaAutonomic dysfunction
* hyperthermia
* sweating
* dilated pupils
* tachycardia
* labile BP
* diarrhoeaNeuromuscular abnormalities
* hyper-reflexia
* myoclonus
* shivering
* ataxiaThat's taken from this site:
http://www.aic.cuhk.edu.hk/web8/serotonin%20syndrome.htmAnother:
The symptoms of the serotonin syndrome can include, but are not limited to:* Euphoric feelings
* Drowsiness / Tiredness
* Sustained rapid eye movement
* Overreaction of the reflexes
* Rapid muscle contraction and relaxation in the ankle causing abnormal movements of the foot
* Clumsiness
* Restlessness
* Feelings of being drunk or dizzy
* Muscle contraction and relaxation in the jaw
* Sweating
* Intoxication
* Twitching of the muscles
* Rigidity
* High body temperature
* Mental status changes
http://www.anxiety-and-depression-solutions.com/serotonin-syndrome.htmWhat's going on with you? What are you feeling that makes you worry?
xoxo
Posted by Meri-Tuuli on April 4, 2006, at 16:06:16
In reply to What if I didn't wait long enough, posted by Maxime on April 4, 2006, at 14:43:27
Hi again!
How long was it exactly? Was it five weeks??
Anyway there's another link for sertonin syndrome...
http://en.wikipedia.org/wiki/Serotonin_syndrome
I really hope you are okay.....
Kind regards
Meri
Posted by ed_uk on April 4, 2006, at 16:46:04
In reply to What if I didn't wait long enough, posted by Maxime on April 4, 2006, at 14:43:27
Hi Maxie
What are your symptoms?
I think you should stop the Parnate and restart it after two more weeks.
Ed xx
Posted by SLS on April 4, 2006, at 17:04:22
In reply to What if I didn't wait long enough, posted by Maxime on April 4, 2006, at 14:43:27
> Hi
>
> I am wondering what symptoms I would have if I didn't wait long enough to let the Prozac clear from my system.
>
> I am really not feeling very well.
>
> Maxime
I know everyone is concerned about serotonin syndrome, but I find it difficult to believe that two days at 30mg produces sufficient MAO inhibition to cause it. You should get your blood pressure checked in any event. Some people experience hypertensive episodes when they first start taking Parnate. They can even appear later in treatment in the absence of tyramine or drug interactions.In what ways are you not feeling well?
- Scott
Posted by blueberry on April 4, 2006, at 19:30:17
In reply to What if I didn't wait long enough, posted by Maxime on April 4, 2006, at 14:43:27
I don't know about serotonin syndrome. I mean, the potential is obviously there. But then again, your doc probably wouldn't have allowed it if he had any doubts.
I would be slightly more inclined to think in terms of prozac withdrawals. Your body is just now being introduced to a strange new molecule, which in itself could cause some not well feelings. But in addition, there are prozac withdrawals going on too. Its withdrawals are not so sudden as other ssri's, but I know from personal experience they are real and they can be severe. When prozac was nearly out of my system, it got downright scary how aweful I felt.
Just because the maoi is holding up serotonin levels doesn't mean you aren't still going to feel withdrawals from removal of the prozac molecule.Just a thought. I think for the majority of people, stopping any ssri regardless of what other med immediately takes its place is going to cause some very not-well feelings...flu like kind of stuff, muscle cramps, lethargy or anxiety, tremors and shaking, sleep problems, etc. All jumbled up and confused with new side effects of the maoi.
It's tough I know. To be safe, you might want to cut the maoi in half, or maybe do it once every other day, for a couple weeks. And call the doctor if you instincts tell you something is wrong.
Posted by SLS on April 4, 2006, at 19:53:13
In reply to Re: What if I didn't wait long enough » Maxime, posted by blueberry on April 4, 2006, at 19:30:17
> I would be slightly more inclined to think in terms of prozac withdrawals.
That's an excellent thought.
I'm still wondering in what ways Maxime feels unwell.
- Scott
Posted by Maxime on April 5, 2006, at 10:32:43
In reply to What if I didn't wait long enough, posted by Maxime on April 4, 2006, at 14:43:27
> Hi
>
> I am wondering what symptoms I would have if I didn't wait long enough to let the Prozac clear from my system.
>
> I am really not feeling very well.
>
> Maxime
Well I had another hypertensive episode yesterday which I needed 100 mg thorazine to calm dowm. I am not having any of those systems that Racer listed. I think it may have been from the mochachino (that's no how you spell it) I had. It has chocolate in it. That is the only thing I could have eaten to cause it.I took the bus back home and I had to stand and I felt like I was going to pass out. I tried to feel my pulse but it was going so fast that I couldn't even count it.
Sigh. I must be more careful. Funny when I was on it before I could eat whatever I wanted!
Maxime
Posted by Phillipa on April 5, 2006, at 17:23:14
In reply to Re: What if I didn't wait long enough, posted by Maxime on April 5, 2006, at 10:32:43
Maxie body changes? Hope you are okay. Love Phillipa
This is the end of the thread.
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