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Dr. Bob is Robert Hsiung, MD,
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Posted by jtevers on February 2, 2005, at 18:44:24
has anyone heard of osanetant or talnetant for the treatment of psychotic disorders like schizophrenia?
they are NK3 antagonists that are probably as effective as atypical antipsychotics at remedying psychosis. both are in phase II development, but there is little literature out there.
they apparently lack many of the more serious side effects of current antipsychotic therapy.
john
pennsylvania
Posted by SadDoggie on February 2, 2005, at 20:43:12
In reply to NEW...OSANETANT or TALNETANT for schizophrenia, posted by jtevers on February 2, 2005, at 18:44:24
Thanks for the heads up on this. I had totally forgotten to read up on upcoming antipsychotics, which I should be doing.
SadDoggie
> has anyone heard of osanetant or talnetant for the treatment of psychotic disorders like schizophrenia?
>
> they are NK3 antagonists that are probably as effective as atypical antipsychotics at remedying psychosis. both are in phase II development, but there is little literature out there.
>
> they apparently lack many of the more serious side effects of current antipsychotic therapy.
>
> john
> pennsylvania
Posted by SLS on February 3, 2005, at 6:03:45
In reply to NEW...OSANETANT or TALNETANT for schizophrenia, posted by jtevers on February 2, 2005, at 18:44:24
> has anyone heard of osanetant or talnetant for the treatment of psychotic disorders like schizophrenia?
>
> they are NK3 antagonists that are probably as effective as atypical antipsychotics at remedying psychosis. both are in phase II development, but there is little literature out there.
>
> they apparently lack many of the more serious side effects of current antipsychotic therapy.
Hi John.I hadn't know of these two drugs. They are not mentioned prominently on Medline in association with schizophrenia. I did find something on Google which seemed like a pretty good review of what's going on. I guess you've already seen it.
http://www.drugdevelopment-technology.com/projects/osanetant/
- Scott
Posted by jtevers on February 3, 2005, at 19:05:54
In reply to Re: NEW...OSANETANT or TALNETANT for schizophrenia, posted by SadDoggie on February 2, 2005, at 20:43:12
SLS and Saddoggie,
thanks for your response, SLS, i have in fact read that article and more...
saddoggie, you might be interested in the following sigts that list some drugs in the "pipeline."
http://psychmeds.healingwell.com/
http://www.neurotransmitter.net/newdrugs.html
and the "list of drugs in development for neurodegenerative diseases" that you can link to from the above mentioned neurotransmitter.net site or title search for on your own.
hope this helps ... i appreciate both of yours.
john
Posted by SadDoggie on February 3, 2005, at 20:24:21
In reply to Re: NEW...OSANETANT or TALNETANT for schizophrenia, posted by jtevers on February 3, 2005, at 19:05:54
SLS,
Thanks for the links.
Posted by jtevers on December 18, 2005, at 17:03:47
In reply to NEW...OSANETANT or TALNETANT for schizophrenia, posted by jtevers on February 2, 2005, at 18:44:24
To all the hopeful:
The prospect of new and improved antipsychotics without the current horrible side effects, like weight-gain, has been diminished with the cancellation, while in phase II, of osanetant. The hope that talnetant, a similar medication being tested by glaxo-smithkline, will prove effective enough to gain phase III status remains to be seen.
Talnetant, like osanetant had been, is a neurokinin-3 antagonist currently in trials for treatment of schizophrenia. It has recently been dropped from further development for the treatment of IBS. Let's hope its prospect for the treatment of psychosis remains more promising and that in a couple of years we may have a true, new alternative for the treatment of what ails us.
The progress of talnetant within gsk's research and development portfolio could be followed at:
http://www.gsk.com/financial/pp_pipeline_standard.htmLet's cross our fingers.
John
Pennsylvania
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