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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by sdb on October 4, 2005, at 6:03:49
Some months ago I took bromazepam 18mg once a day to test because of curiosity and I did not notice any effect (like a glass of H20). Many people told me bromazepam would be a very effective, activating bz especially against anxiety. In literature it has reputation as an addictive bz. But for me it was like placebo. Tablets are sold 6mg, according to a study (social phobia) 21mg would be needed for a very good result (Versiani et. al.)
Clonazepam has definately efficacy and even stabilizing properties which is good in my case with BP and some anxiety.
After reading and doing some research of different substance classes, bz's seem to be very variable in efficacy and in the developpement of tolerance from person to person. A patient can take the dosage of 1/10 of another patient with same results but thus big difference in dosage amount to reach the same effect.
Any thoughts about that?
kind regards
sdb
Posted by blueberry on October 4, 2005, at 16:46:03
In reply to Bz's seem to be very variable from person to perso, posted by sdb on October 4, 2005, at 6:03:49
I think you're right, different benzos have different effects on different people. An emergency room doctor once told me that they are all the same except for their half lives. Geez, that's ridiculous. They're completely different molecules.
I also found that different doses act differently. For example, .25mg xanax to me provides relaxation and motivation at the same time. It's a great antidepressant at that dose. But, if I take .50mg, it justs feels like a sleeping pill and makes me kind of depressed. It amazes me that just a .25mg difference in dose has such a different effect on me.
Posted by sdb on October 4, 2005, at 18:55:05
In reply to Re: Bz's seem to be very variable from person to perso, posted by blueberry on October 4, 2005, at 16:46:03
Maybe the emergency room doctor only uses diazepam...I think he relates bz's in efficacy of sedation.
Most of the benzos do really the same but there are differences of these substances in liver transformation and especially in one case gastrointestinal absorption.
But there are bz's other than these transforming in the N-Demethyl-Metabolites which targets different locations on benzodiazepinrezeptors.
I think reasons for different actions on individiuals are:
-Does he/she took much bz's or alcohol before
-Differences from person to person of gaba receptors
-Bigger and smaller differences of different receptor binding sites (even alcohol can have different reactions to persons, one can be aggressive the other only sedated taken the same dosage; I personally have zero response of 18mg bromazepam)
-Sedation is probably one property which almost every bz has dosage depended, regardless of substance classBut of course emergency docs dont understand much about chemistry and physiology/biologie of receptors and membranes. They care about other things.
Bye the way a doc told me betablockers would do all the same. But thats absolutely not true, maybe they all lower bloodpressure but there are not big differences (blocking reaction to noradrenaline of nervi cardiaci, catecholamines, ISA, antioxidant properties, selectivity of b1/b2, there are much more b2-rec. on heart tissue than previously believed)
Sorry my long message but I dont like generalized states like that from the emergeny doctor. It's much more complicated.
Thanks for your answer.
kind regards
sdb
Posted by sdb on October 4, 2005, at 19:09:10
In reply to Re: Bz's seem to be very variable from person to perso, posted by sdb on October 4, 2005, at 18:55:05
sorry correction:
they all lower bloodpressure but there are big differences in....and also in endocrinology
Posted by Phillipa on October 4, 2005, at 20:58:16
In reply to Re: Bz's seem to be very variable from person to perso, posted by sdb on October 4, 2005, at 19:09:10
Blueberry, that's exactly what happened to me a long time ago when I wasn't depressed. Hated that feeling of fatigue. As a matter of fact that's why I stopped xanax it no longer provided anxiety relief just made me tired. Fondly, Phillipa
Posted by tizza on October 5, 2005, at 0:32:42
In reply to Re: Bz's seem to be very variable from person to perso, posted by Phillipa on October 4, 2005, at 20:58:16
I made a similar response to this the other day. What different benzo's do to me. Temezapam 20mg, makes me chatty and alert, no sleep. Xanax .25mg same affect, feel great. Xanax 1mg lethargic and sleepy. Valium 10mg takes the edge off if I'm anxious but if I'm not anxious it can make me very chatty but in laid back way, so it's good for my social anxiety. Ativan 3mg doesn't give me a laid back feeling it just makes me feel normal. Mogadon(nitrazepam) 5mg is the best hypnotic but has a long half life so you can feel a little groggy in the morning until you hit the shower. Klonopin at any strength makes me messy and so does rohypnol but I don't think that you can get it anymore in Australia but it was the best hypnotic ever made. To bad people had to abuse it for EVIL purposes
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