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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by ed_uk on August 22, 2005, at 17:01:57
Eur Neuropsychopharmacol. 2005 Aug 15
Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats.
Selective Serotonin Reuptake Inhibitors (SSRIs) are designed to treat adults, but are increasingly prescribed for adolescents. SSRIs might cause permanent changes in serotonin-related behavior in adolescents, since their serotonergic system is still developing. Male Wistar rats were treated with paroxetine (15 mg/kg p.o.) or fluvoxamine (30 mg/kg p.o.) throughout adolescence. After a washout period their behavior in the elevated plus-maze, prepulse inhibition test, Forced swimming test and elevated T-maze were studied. In addition, the effects of the 5-HT(1A) receptor agonist 8-OH-DPAT on sexual behavior and lower lip retraction were measured. Paroxetine mildly inhibited weight gain during treatment. Both SSRIs caused a reduction in ejaculation frequency and in time spent on the open arm of the elevated plus-maze in adult rats. Fluvoxamine slightly increased avoidance latency in the elevated T-maze compared to paroxetine. No differences between the groups were found in the other tests. Apparently, chronic treatment with SSRIs during adolescence may cause mild changes in adult behavior.
~ed
Posted by Ilene on August 22, 2005, at 17:57:29
In reply to SSRI use in children *might* affect development, posted by ed_uk on August 22, 2005, at 17:01:57
I hope this finding isn't going to be blown out of proportion.
1) I think depression in adolescents leads to changes in behavior in adulthood.
2) My pdoc says the longer a brain is "injured" by depression, the more likely a person is to become depressed again.
So I think depression in children needs to be treated, by drugs if necessary.
I.
Posted by ixus on August 22, 2005, at 18:35:06
In reply to SSRI use in children *might* affect development, posted by ed_uk on August 22, 2005, at 17:01:57
Hi Ed,
what is your next step then? CBT? :-)
/ixus
Posted by linkadge on August 22, 2005, at 20:20:35
In reply to Re: SSRI use in children *might* affect development » ed_uk, posted by ixus on August 22, 2005, at 18:35:06
Interesting. I think that a lot of the information to push antidepressants is flawed.
For instance my doctor told me that the SSRI's will prevenent stress and depression induced hippocampal shrinkage.
The problem is this. This has never been proven conclusivly in humans or rats. One of the main studies showed that Tianaptine and clompiramine showed moderate hippocampal sparing effects, but that fluoxetine showed no such effect. Critics said that these results were being extended to SSRI's without any proof at all.
TCA's and Tianeptine probably have a more marked effect on HPA axis normalization than SSRI's.
I've actually read many studies that show the opposite, that SSRI's increase cortisol.
I think this is why TCA's may poop out less.Linkadge
Posted by ed_uk on August 23, 2005, at 16:08:35
In reply to Re: SSRI use in children *might* affect development » ed_uk, posted by Ilene on August 22, 2005, at 17:57:29
Hi Ilene,
I like to keep a sense of balance :-)
~Ed
Posted by ed_uk on August 23, 2005, at 16:09:41
In reply to Re: SSRI use in children *might* affect development » ed_uk, posted by ixus on August 22, 2005, at 18:35:06
Hi Ixie!
I did some CBT as a child, it didn't help. Paroxetine 40mg was helpful..... but at a price - sedation and apathy.
Kind regards
~Ed
Posted by ed_uk on August 23, 2005, at 16:12:12
In reply to Re: SSRI use in children *might* affect development, posted by linkadge on August 22, 2005, at 20:20:35
Hi Link,
>I've actually read many studies that show the opposite, that SSRI's increase cortisol.
I think it's a short term effect. Do you agree?
Kind regards
~Ed
Posted by linkadge on August 23, 2005, at 16:23:02
In reply to Re: SSRI use in children *might* affect development » linkadge, posted by ed_uk on August 23, 2005, at 16:12:12
Down the road it might normalize. I always felt off kilter while on SSRI's. I know that within the 5 years I took them, I never slept properly.
I would sleep 14 hours but not sleep at all.
Goodness knows that side effect takes a toll on the developing mind. I also have a suspicion that sexual side effects during adolecence could be indicative of the alteration of hormones most likely critical to developement.
Approaching my 6 month of continuous brain zaps, I would hazard to change the *might* in that statement.
Linkadge
This is the end of the thread.
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