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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by pseudoname on August 19, 2005, at 17:50:59
Why can't you take grapefruit or other citrus foods with Adderall or other amphetamines? Something on the web says they'll make your stomach too acidic, but grapefruit juice has a ph of 3 and stomach acid is ph 1, so I don't see how that can be it. Something else says citrus blocks the absorption of amphetamine. Can someone explain it?
Thanks.
Posted by crazychickuk on August 19, 2005, at 18:22:17
In reply to citrus and Adderall - please explain, posted by pseudoname on August 19, 2005, at 17:50:59
Its with all antidepressants. i dont know why sorry
but i do know from experience it has bad reaction to me (without knowing the info i do now)
when i was on a diet on an ssri i had grapefruit and i was climbing the walls with anxiety..
even now i dont take no ad's i still wont touch it i avoid it..
Posted by Declan on August 19, 2005, at 18:49:46
In reply to Re: citrus and Adderall - please explain, posted by crazychickuk on August 19, 2005, at 18:22:17
Flavanoids in the grapefruit inhibiting liver enzymes??
This is a quote about grapefruit. (I dunno if it is at *all* relevant to Adderal).
'The major interaction seems to be in the gut wall with enzymes belonging to various cytochrome P-450 subfamilies. It also appears to inhibit renal 11-beta-hydoxysteroid dehydrogenase in humans and could therefore potentiate side effcts from licorice. Although the flavanoids naringen and naringenin were first implicated, they are probably not the only active components. In fact the furanocoumarin bergamottan and related compounds appear to be largely responsible for this activity. This ability of plant furanocoumarins to inhibit drug metabolising enzymes was first noted by Korean researchers in 1983. This phenomenon raises the question of how other plants and their phytochemicals may influence the bioavailability of both drugs and herbal constitiuents.'
(So much for the food/drug dichotomy).
But there is a thing about the metabolism of amphetamine being ph dependant too. Alkalysing your urine will retard excretion and acidifying it will increase it.
Declan
Posted by Ilene on August 19, 2005, at 19:29:13
In reply to citrus and Adderall - please explain, posted by pseudoname on August 19, 2005, at 17:50:59
> Why can't you take grapefruit or other citrus foods with Adderall or other amphetamines? Something on the web says they'll make your stomach too acidic, but grapefruit juice has a ph of 3 and stomach acid is ph 1, so I don't see how that can be it. Something else says citrus blocks the absorption of amphetamine. Can someone explain it?
>
> Thanks.I couldn't find anything specific about interactions between Adderall and grapefruit juice, but here's an abstract of an article about grapefruit juice and drug interactions:
Clin Ter. 2005 May-Jun;156(3):97-103.
[Grapefruit juice: potential drug interaction]
[Article in Italian]
Palumbo G, Bacchi S, Palumbo P, Primavera LG, Sponta AM.
Farmacologia Medica, Dipartimento di Medicina Interna e Sanita Pubblica, Universita degli Studi di L'Aquila, Italia. gpalumbo@cc.univaq.it
More than a decade has passed since it was unintentionally discovered that grapefruit juice interacts with certain drugs. The coadministration of these drugs with grapefruit juice can markedly elevate drug bioavailability, and can alter pharmacokinetic and pharmacodynamic parameters of the drug. The predominant mechanism for this interaction is the inhibition of cytochrome P-450 3A4 in the small intestine, resulting in a significant reduction of drug presystemic metabolism. An additional mechanism is the inhibition of P-glycoprotein, a transporter that carries drug from the enterocyte back to the gut lumen, resulting in a further increase in the fraction of drug absorbed. Some calcium channel antagonists, benzodiazepines, HMG-CoA reductase inhibitors and cyclosporine are the most affected drugs. A single exposure to one glass of the grapefruit juice can usually produce the maximal magnitude of the interaction. The data available so far, concerning this interaction and its clinical implications, are reviewed in this article. It is likely that more information regarding this interaction will accumulate in the future, and awareness of such is necessary for achieving optimal drug therapy.
I.
Posted by pseudoname on August 20, 2005, at 11:32:15
In reply to citrus and Adderall - please explain, posted by pseudoname on August 19, 2005, at 17:50:59
This is the end of the thread.
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