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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on July 9, 2005, at 22:50:01
This article seems to suggest that 5-ht1c stimulation promotes neurogenesis too. This may be why periactin blocks some of the antidepressant effects of SSRIs ??
Maybe the antidepressant/sexual effects of the drugs ae inseperable.
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Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone.
Neuropsychopharmacology. 2004 Mar;29(3):450-60.
Increase in serotonin (5-HT) transmission has profound antidepressant effects and has been associated with an increase in adult neurogenesis. The present study was aimed at screening the 5-HT receptor subtypes involved in the regulation of cell proliferation in the subgranular layer (SGL) of the dentate gyrus (DG) and the subventricular zone (SVZ) and to determine the long-term changes in adult neurogenesis. The 5-HT1A, 5-HT1B, and 5-HT2 receptor subtypes were chosen for their implication in depression and their location in/or next to these regions. Using systemic administration of various agonists and antagonists, we show that the activation of 5-HT1A heteroreceptors produces similar increases in the number of bromodeoxyuridine-labeled cells in the SGL and the SVZ (about 50% over control), whereas 5-HT2A and 5-HT2C receptor subtypes are selectively involved in the regulation of cell proliferation in each of these regions. The activation of 5-HT2C receptors, largely expressed by the choroid plexus, produces a 56% increase in the SVZ, while blockade of 5-HT2A receptors produces a 63% decrease in the number of proliferating cells in the SGL. In addition to the influence of 5-HT1B autoreceptors on 5-HT terminals in the hippocampus and ventricles, 5-HT1B heteroreceptors also regulate cell proliferation in the SGL. These data indicate that multiple receptor subtypes mediate the potent, partly selective of each neurogenic zone, stimulatory action of 5-HT on adult brain cell proliferation. Furthermore, both acute and chronic administration of selective 5-HT1A and 5-HT2C receptor agonists produce consistent increases in the number of newly formed neurons in the DG and/or olfactory bulb, underscoring the beneficial effects of 5-HT on adult neurogenesis.Linkadge
Posted by ed_uk on July 10, 2005, at 7:55:36
In reply to 5-ht1c stimulation promotes neurogenesis too, posted by linkadge on July 9, 2005, at 22:50:01
>This article seems to suggest that 5-ht1c stimulation promotes neurogenesis too. This may be why periactin blocks some of the antidepressant effects of SSRIs ??
AFAIK, Periactin only acts at 5-HT2 receptors.
~Ed
Posted by linkadge on July 10, 2005, at 15:31:24
In reply to Re: 5-ht1c stimulation promotes neurogenesis too » linkadge, posted by ed_uk on July 10, 2005, at 7:55:36
Posted by linkadge on July 10, 2005, at 15:32:11
In reply to Sorry I wrote 1c meant 2c (nm), posted by linkadge on July 10, 2005, at 15:31:24
The article links it to 2c stimulation. I had in my mind 2c but wrote 1c for some reason.
Linkadge
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