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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Declan on July 3, 2005, at 19:10:27
Hey Ed and everyone,
You know the graph of MAO inhibition and Parnate dose, where I think, roughly, there is 20% MAO inhibition from 20mg Parnate/day. Well since I'm on 10mg, there can't be significant inhibition really. (Is that right?) So I shouldn't have to worry about the food thing and drug interactions?
And as I get all this effect from 10mg, am I getting it from some other property of Parnate altogether, from that immediate effect it has? How does the immediate effect work?
Declan
Posted by superman on July 4, 2005, at 4:35:48
In reply to Avocados, Parnate, MAO inhibition, posted by Declan on July 3, 2005, at 19:10:27
> Hey Ed and everyone,
>
> You know the graph of MAO inhibition and Parnate dose, where I think, roughly, there is 20% MAO inhibition from 20mg Parnate/day. Well since I'm on 10mg, there can't be significant inhibition really. (Is that right?) So I shouldn't have to worry about the food thing and drug interactions?That seems like a reasonable hypothesis. You can't be sure about these things tho until you test it i think. Perhaps the Mao in the gut is affected nearly as much by 10mg as 80. Perhaps there's some completely counter-intuitive reason you would still have to be careful about the food and drug interactions.
Sounds like you want to eat your avacado. I don't blame you. I'd give it a test.
> And as I get all this effect from 10mg, am I getting it from some other property of Parnate altogether, from that immediate effect it has? How does the immediate effect work?
>I'm pretty sure the effects I've noticed from the 20-30mg I've been taking are largely not due to the Maoi inhibition. There seems to be a lot of talk about an amphetamine-like metabolite. I imagine this may be one reason it helps me with my depression.
Who knows what other 'immediate' effects parnate has regardless of its MAO inhibition. For one, I notice after a dose at an almost exact time each day very obvious effects. To me the fact this occurs (almost always) when plasma levels of parnate itself *should* be highest, and is relatively short lived, suggests its not necissarily the MAO inhibition. The effects include an extremely relaxing fatigue, and perhaps some mild euphoria (that I can enjoy so long as I don't get stuck in any depressing thoughts). I imagine someone who was tense and agitated most often might not complain about the fatigue quite as much as I do. I'm thinking the mechanisms of the drug are not fully understood, eventhough they seem to attest it to be because of its MAO inhibition. I don't know tho, just my thought.
Hmm, I'm doing a search for studies done on parnate. It's clear parnate affects your body chemistry in more ways than just inhibiting MAO. So, maybe you are getting benefits from some other effect, as I believe i am. I'm glad its helping you tho (it is helping right?). I'm interested in what others have to say or know about this topic.
Cheers,
T
Posted by Declan on July 4, 2005, at 15:56:14
In reply to Re: Avocados, Parnate, MAO inhibition, posted by superman on July 4, 2005, at 4:35:48
Hi T
You're right, you can't be sure. My BP went up last night a bit, I could tell. (Whisky? chocolate? cannabis?)
Yeah, extremely relaxing fatigue, and mild euphoria, that's it. Because I only take 10mg I don't get the hypotension in a noticeable way.
I wanna look at all the enzymes and whatever else that are inhibited by Parnate. There was quite a list I read about with Nardil.Is it helping me? Yes, an AD worthy of the name, not that I've taken many, I'm just sceptical about psych drugs. I spent a couple of years on phenothiazines when I was young, for no good reason at all.
You sleep OK? I'm not worried about the avocado, no idea how that person got into trouble with it.
Declan
Posted by ed_uk on July 4, 2005, at 17:06:37
In reply to Avocados, Parnate, MAO inhibition, posted by Declan on July 3, 2005, at 19:10:27
Hi Declan,
T made a good point about MAO in the gut. If 10mg Parnate inhibits this enzyme to a significant degree, you absorb a lot of tyramine!
~Ed
Posted by linkadge on July 4, 2005, at 18:43:26
In reply to Re: Avocados, Parnate, MAO inhibition » Declan, posted by ed_uk on July 4, 2005, at 17:06:37
Doesn't parnate also have some effects on monamine uptake ??
Linkadge
Posted by ixus on July 6, 2005, at 13:52:16
In reply to Avocados, Parnate, MAO inhibition, posted by Declan on July 3, 2005, at 19:10:27
> Hey Ed and everyone,
>
> You know the graph of MAO inhibition and Parnate dose, where I think, roughly, there is 20% MAO inhibition from 20mg Parnate/day. Well since I'm on 10mg, there can't be significant inhibition really. (Is that right?) So I shouldn't have to worry about the food thing and drug interactions?
>
> And as I get all this effect from 10mg, am I getting it from some other property of Parnate altogether, from that immediate effect it has? How does the immediate effect work?
>
> DeclanHi,
I have done a lot of experiments. At 20mg I drank beers, no hypertention. However I noticed BP increasal after a glass of beer at 40. There is no rule for anyone. Keep this in mind.
/ixus
This is the end of the thread.
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