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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by mmcconathy on March 22, 2005, at 21:57:45
I dont know much about the controversy about AD's reviving receptors, or growing new ones.
MOAI's prevent oxidation, could this in long term let cells gernerate.
I've also heard Selegine has anti-aging properties.
Ignore this if you hate me.
Thanks
Posted by Phillipa on March 22, 2005, at 22:57:57
In reply to does Parnate or Selegine produce cell growth?, posted by mmcconathy on March 22, 2005, at 21:57:45
Matt, we don't hate you. And I'm not a therapist just was an RN in psych. I'm sorry I can't answer your question. It's one for the drug experts. Fondly, Phillipa PS I'm not currently working.
Posted by ixus on March 23, 2005, at 0:52:09
In reply to does Parnate or Selegine produce cell growth?, posted by mmcconathy on March 22, 2005, at 21:57:45
This is why I take Parnate. I want to live forever! ;-)
/ixus
> I dont know much about the controversy about AD's reviving receptors, or growing new ones.
>
> MOAI's prevent oxidation, could this in long term let cells gernerate.
>
> I've also heard Selegine has anti-aging properties.
>
> Ignore this if you hate me.
>
> Thanks
Posted by djmmm on March 23, 2005, at 10:10:27
In reply to does Parnate or Selegine produce cell growth?, posted by mmcconathy on March 22, 2005, at 21:57:45
> I dont know much about the controversy about AD's reviving receptors, or growing new ones.
>
> MOAI's prevent oxidation, could this in long term let cells gernerate.
>
> I've also heard Selegine has anti-aging properties.
>
> Ignore this if you hate me.
>
> ThanksHere's some info..
http://www.ceri.com/deprenyl.htm
Posted by Larry Hoover on March 23, 2005, at 15:53:03
In reply to Re: does Parnate or Selegine produce cell growth?, posted by djmmm on March 23, 2005, at 10:10:27
> Here's some info..
> http://www.ceri.com/deprenyl.htmOkay, I'm convinced.
Oh, yeah, I'm already taking selegeline. ;-)
Lar
Posted by SLS on March 23, 2005, at 17:46:51
In reply to Re: does Parnate or Selegine produce cell growth? » djmmm, posted by Larry Hoover on March 23, 2005, at 15:53:03
>
> > Here's some info..
> > http://www.ceri.com/deprenyl.htm
>
> Okay, I'm convinced.
>
> Oh, yeah, I'm already taking selegeline. ;-)
>
> Lar
>The article and the bibliography citations for the article were written prior to 1993. It has since been debated whether it is truly neuroprotective or not. I think much of the newer work refutes the neuroprotective effects of deprenyl.
I really don't know where things are at in 2005. I haven't researched deprenyl in quite a while.
- Scott
Posted by Mistermindmasta on March 23, 2005, at 23:07:32
In reply to does Parnate or Selegine produce cell growth?, posted by mmcconathy on March 22, 2005, at 21:57:45
Usually, if an antidepressant has clinical action, this clinical effect corresponds with an increase in cell growth in the hippocampus and an increase in activity in the prefrontal cortex and nucleus accumbens. I can get resources for you, if you'd like. But generally speaking, I believe that most antidepressants seem to produce cell growth especially in the hippocampus, and I think this would include Parnate and Selegine.
Posted by Sarah T. on March 24, 2005, at 0:23:26
In reply to Re: does Parnate or Selegine produce cell growth?, posted by SLS on March 23, 2005, at 17:46:51
> > > The article and the bibliography citations for the article were written prior to 1993. It has since been debated whether it is truly neuroprotective or not. I think much of the newer work refutes the neuroprotective effects of deprenyl.> - Scott
>Hi Scott. A couple of years ago, my psychiatrist told me exactly what you just mentioned, i.e., that more recent research refutes the neuroprotective effects of deprenyl. Even before he said that, I found it difficult to believe that a drug that metabolizes into methamphetamine could be neuroprotective.
Posted by djmmm on March 24, 2005, at 11:09:44
In reply to Re: does Parnate or Selegine produce cell growth? » SLS, posted by Sarah T. on March 24, 2005, at 0:23:26
> > > > The article and the bibliography citations for the article were written prior to 1993. It has since been debated whether it is truly neuroprotective or not. I think much of the newer work refutes the neuroprotective effects of deprenyl.> - Scott
> >
>
> Hi Scott. A couple of years ago, my psychiatrist told me exactly what you just mentioned, i.e., that more recent research refutes the neuroprotective effects of deprenyl. Even before he said that, I found it difficult to believe that a drug that metabolizes into methamphetamine could be neuroprotective.
>
>MAO-B inhibition attenuates the oxidization of dopamine into nurotoxins (6-hydroxydopa and 6-hydroxydopamine)
The neuroprotective rationale behind MAOb inhibitors is twofold: firstly, referring back to Equation 1, if MAOb is inhibited, less H2O2 is produced and thus fewer OH• are produced which limits oxidative stress. In addition, Selegiline induces free radical scavenging enzymes, SuperOxidase Dismutase (SOD) and catalase which will limit free radical damage [18]. Secondly, MAOb is required for the conversion of MPTP to MPP+ [Figure 4] so if any such toxin (either endogenous or exogenous) is responsible for PD, limiting this reaction would have neuroprotective benefits. Indeed, increased longevity has been reported for selected selegiline patients [22]. Selegiline is metabolised to amphetamines and desmethylselegiline. The latter has been shown to reduce apoptotic neuronal death in vitro [19] . Higher ratios of this metabolite is achieved via the transdermal [20] or subcutaneous [19] routes which are now being explored for neuroprotective effects.http://www.chemsoc.org/exemplarchem/entries/2003/nottingham_russell/2.html
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