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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by SadDoggie on February 2, 2005, at 7:03:04
I've read a lot about NMDA antagonists(memantine, amantadine) preventing tolerance to amphetamines. I've also seen a lot of people here suggest it to others but haven't seen any who actually did it. Has anyone here actually taken adderral or dexedrine with it and prevented tolerance? I am treatment-resistant, nothing works, or barely works, and if it does, it don't work for long. I would like to try one of these drugs with memantine if it really works. Who knows, if I'm lucky it might actually help my depression.
Posted by EERRIICC on February 2, 2005, at 7:34:14
In reply to Amphetamine Memantine, posted by SadDoggie on February 2, 2005, at 7:03:04
I'm going to try the combination if I can, I'll find out today. A psychobabble poster named andrewb tried it with great success. His postings on the subject are very informed. Please post if you try the combination. Good luck.
Eric
Posted by SadDoggie on February 2, 2005, at 7:51:48
In reply to Re: Amphetamine Memantine, posted by EERRIICC on February 2, 2005, at 7:34:14
Oh great, let us know how it goes. And Good luck. I actually did see one of AndrewB's posts while I was doing a search, I hope he's not the only one :) If I see others have actually done it I'd like to try it myself soon, but I don't have the stuff on hand yet ;)
> I'm going to try the combination if I can, I'll find out today. A psychobabble poster named andrewb tried it with great success. His postings on the subject are very informed. Please post if you try the combination. Good luck.
>
> Eric
Posted by CareBear04 on February 2, 2005, at 14:13:21
In reply to Re: Amphetamine Memantine, posted by SadDoggie on February 2, 2005, at 7:51:48
please let me know what you find out!!! i'm maxed out on adderall at 60mg a day. i'm switching over to concerta for awhile in the hope that it'll give me a bit of the kick that i'm missing. adderall used to work like a charm, calming me down, helping me focus and pay attention, and making me more alert. i'm only 21, and if stimulants poop out on me now, i don't know what i'll do for the rest of my life. if any of these solutions work, please let me know! although my pdoc doesn't specialize in drugs... she may be suspicious if i suggest something non-mainstream.
Posted by SadDoggie on February 2, 2005, at 17:58:32
In reply to Re: Amphetamine Memantine, posted by CareBear04 on February 2, 2005, at 14:13:21
I'll let you know, I'll get around to trying it within a month or so because right now I'm giving the benzos a try. I also have to get a hold of them as obviously my psychiatrist won't prescribe amphetamines (how do so many people here get adderall? Are these all people with ADD)? Also, let me tell you that you shouldn't put too much weight on my trial since I am VERY treatment-resistant, there are other people trying it too.
Good Luck,
SadDoggie> please let me know what you find out!!! i'm maxed out on adderall at 60mg a day. i'm switching over to concerta for awhile in the hope that it'll give me a bit of the kick that i'm missing. adderall used to work like a charm, calming me down, helping me focus and pay attention, and making me more alert. i'm only 21, and if stimulants poop out on me now, i don't know what i'll do for the rest of my life. if any of these solutions work, please let me know! although my pdoc doesn't specialize in drugs... she may be suspicious if i suggest something non-mainstream.
Posted by CareBear04 on February 2, 2005, at 22:35:05
In reply to Re: Amphetamine Memantine, posted by SadDoggie on February 2, 2005, at 17:58:32
saddoggie,
are you in the US? i don't know whether getting amphetamines is easier or harder in other countries. i thinkn i'm borderline ADD-- some drs say yes, others blame my inattention and hyperness of bipolar. one dr started me on high-dose wellbutrin, strattera, and provigil. my next pdoc moved to adderall and ritalin. so one dr started the process, and the other dr who had worked with the previous guy, continued the process. i'm also 21 now and have been inattentive and hyper all my life, so i don't know if drs are more willing to prescribe for younger patients who have shown symptoms since childhood. my pdocs have always been very liberal about prescribing controlled substances. if i took everything as prescribed, i would have too many addictions or at least dependencies to count. it's irresponsible prescribing, but for me it's sort of comforting to have these things in stock. keep me posted!
Posted by SadDoggie on February 2, 2005, at 22:51:06
In reply to Re: Amphetamine Memantine » SadDoggie, posted by CareBear04 on February 2, 2005, at 22:35:05
Yes I'm in the US, and it is very hard to get amphetamines prescribed for depression. You get it only if you're ADD. So I have to find a source for it or else find a new psychiatrist and start acting like I have ADD real good :) I don't know what that would be like, like maybe some of the symptoms of depression (like not being able to concentrate) except no depression. Once you showed him you were depressed it's bye bye ADD and bye bye amphetamine.
SadDoggie
> saddoggie,
> are you in the US? i don't know whether getting amphetamines is easier or harder in other countries. i thinkn i'm borderline ADD-- some drs say yes, others blame my inattention and hyperness of bipolar. one dr started me on high-dose wellbutrin, strattera, and provigil. my next pdoc moved to adderall and ritalin. so one dr started the process, and the other dr who had worked with the previous guy, continued the process. i'm also 21 now and have been inattentive and hyper all my life, so i don't know if drs are more willing to prescribe for younger patients who have shown symptoms since childhood. my pdocs have always been very liberal about prescribing controlled substances. if i took everything as prescribed, i would have too many addictions or at least dependencies to count. it's irresponsible prescribing, but for me it's sort of comforting to have these things in stock. keep me posted!
Posted by Pelequin on May 16, 2005, at 16:59:16
In reply to Amphetamine Memantine, posted by SadDoggie on February 2, 2005, at 7:03:04
> I've read a lot about NMDA antagonists(memantine, amantadine) preventing tolerance to amphetamines. I've also seen a lot of people here suggest it to others but haven't seen any who actually did it. Has anyone here actually taken adderral or dexedrine with it and prevented tolerance? I am treatment-resistant, nothing works, or barely works, and if it does, it don't work for long. I would like to try one of these drugs with memantine if it really works. Who knows, if I'm lucky it might actually help my depression.
I have tried the Namenda (aka Memantine)-Adderall combination, and have posted several times, but strangely few have responded to my posts.
Anyway, my experimentation has led me to the following conclusions: I have to take a relatively high dose of Namenda (40-70 mg) in conjunction with a high dose of Adderall (60-70 mg). Namenda seems to slow down the development of Adderall-tolerance and enhances Adderall's effects somewhat.
If you're expecting to be able to take Adderall every day, 5-7 days a week and for the good effects to never diminish, I have bad news for ya. I doesn't work that way. Not even Namenda can make this happen.
For me, taking 40 mg of Namenda + 60-70 mg of Adderall enables me to work a good 4-5 hours every day, but after it wears off..........fog. And even if I increase the dosage on a given day from 60 to 100 or so -- in other words abuse it -- then the good effects are almost neglegible. It's that initial dosage in the morning that is most effective for me.
Keep in mind that it is effective for 4-5 hours, even after the third or fourth week in a row with 0-1 days off per week. So you could argue that 4-5 good hours/day are better than 0 good hours/day.
If you have take Adderall, then I definitely recommend adding Namenda, but don't expect any miracles.
Oh and BTW, Namenda is very expensive.
Posted by SLS on May 17, 2005, at 8:30:18
In reply to Re: Amphetamine Memantine, posted by Pelequin on May 16, 2005, at 16:59:16
This is the end of the thread.
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