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Dr. Bob is Robert Hsiung, MD,
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Posted by rod on November 25, 2004, at 5:19:35
Thats interesting... at least to me
for example:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=540071
----
[Effects of nicergoline on cerebral blood flow ]Iliff LD, Du Boulay GH, Marshall J, Ross Russell RW, Symon L.
Cerebral blood flow (CBF) was measured before and after i.v. injection of the cerebral vasodilator 10-methoxy-1,6-dimethyl-ergoline-8 beta-methanol-(5-bromonicotinate) (nicergoline, Sermion) in 13 patients with cerebrovascular disease. CBF increased in seven. The possibility is discussed that the effect of the drug in the other patients may have been masked by a fall of CBF which occurs during sequential measurement of patients at rest. Nicergoline is an alpha-adrenergic receptor blocking agent which affects cerebral blood flow by reducing cerebrovascular resistance. The present study was undertaken to assess the acute effect of the drug on cerebral blood flow and blood pressure in patients with cerebrovascular diseases.
PMID: 540071 [PubMed - indexed for MEDLINE]
--------Does anybody know more about the alpha-1 and alpha -2 receptor? Whats the functional difference of these two?
And there are *plenty* different vasodilators with anti alpha adrenergic activity.
Things like Co-Dergocrinmesilat, which has beside the apha blocking abilities also stimulates postsynaptic serotonin and dopamine receptors and inhibits Phosphodiesterase (dont know whats this is doing). I find that weired, because I have never heard of them before.
Why do people here only talk about things like adrafinil, modafinil, piracetam, Acetylcholinesterase inhibitors etc. etc. The all make my depression worse (possibly because of their "pro glutamate" or cholinergic activity). And the "dumb drugs" like Clonazepam, Amitriptyline etc. actually halp my stupor feelings. Possibly because of a blood vessel relaxing activity. Amitriptyline blocks alpha receptor and is anticholinergic, which also might cause vasodilation (I have read a paper at pubmed which demonstrate vasodilative properties of atropine (anticholinergic). Why is that? do they also relax the musels aroung the blood vessels? Many anticholinergics are used to relay muscle tensions)
Does someone know more about this? can anybody recommen an alpha-blockers which is most effective to relax cerebral blood vessels?
ok, the arm is not the brain, but it might do the same up there:
----
The effect of amitriptyline on forearm blood flow.Thorstrand C, Lindblad LE.
The local effect of intra-arterial infusion of amitriptyline (AT) on forearm blood flow was studied in seven healthy subjects. AT was infused at rates of 0.05, 0.10, 0.15, and 0.20 mg-min--1 for periods of 5 min. Forearm blood flow showed a dose-dependent increase when the dose exeeded 0.10 mg-min--1. On the highest dose level the blood flow increased on an average by 73%. No systemic effects, as reflected by changes in heart rate, blood pressure, and blood flow in the contralateral forearm, were observed during the infusion. The present data indicate a dilatating effect of AT on resistance vessels possibly mediated by an alpha-adrenergic blockade.
PMID: 1257692 [PubMed - indexed for MEDLINE]
At last, Milnacipran, a SNRI caused a massive stupor, mybe because of the alpha stimulating property.....I honestly think I have a vascular problem. Probaply because of a hypersensitive alpha-noradrenergic receptor.
I have to try one of these....
'nuff said.... :-)
Roland
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